scholarly journals РЕЗИСТЕНТНІСТЬ І ПРОДУКТИВНІСТЬ КРОЛІВ ПРИ ВИКОРИСТАННІ ПРОБІОТИКА «ЕВІТАЛІЯ» В УМОВАХ НОРМАТИВНОГО МІКРОКЛІМАТУ

2016 ◽  
Vol 18 (2(66)) ◽  
pp. 192-197
Author(s):  
N.V. Cherny ◽  
V.V. Kulak
Keyword(s):  
Blood Serum ◽  
Average Daily Gain ◽  
Live Weight ◽  
Lysozyme Activity ◽  
The Body ◽  
Immunological Parameters ◽  
Humoral Factors ◽  
Regulatory Climate ◽  
Cellular Factors ◽  
Definition Of

The influence of probiotic «Evitaliya» hematological, biochemical and immunological parameters of the giant white rabbits in terms of regulatory climate. The studies were performed on young rabbits from birth until 120 days of age, two groups of animals. Experienced groups asked the drug twice a day for 25 ml per head from birth to 30 days of age, and then 50 ml on the head (from 31 – to 90– day age). To assess the effect of the probiotic on the body of the rabbit used hygienic methods of research (definition of temperature and humidity, bacterial obremenjenosti air, light); clinical (body temperature, pulse rate and respiration); hematological (erythrocytes, hemoglobin, leukocytes); immunological (bactericidal and lysozyme activity of blood serum, phagocytes index, phagocytes activity of neutrophils (FAN); livestock (live weight and SSP), statistical.Studies found that the use of rabbits with probiotic ferment «Evitaliya» in doses of 25 ml per head and 50 ml / head twice a day for 5 days with breaks of 10 the bottom, contribute to the activation of redox processes in the intestine and the body as a whole, stimulation of humoral and cellular factors of protection, the intensive growth. The studies revealed the following:– increased in the blood of rabbits (age 10–30–60 days) red blood cell count 8.8 – 9.2%, leucocytes – 4,7 – 5,1%, the concentration of hemoglobin – 5.3 – 7.1 per cent– increased humoral factors of protection up to: bactericidal activity of blood serum – to 36.46,0 ± 0.38 – of 55.15 ± 0.40 percent, lysozyme activity of blood serum to 36.14 ± 0.79 – 40.18 ± 0.83;– cellular factors of protection: the phagocytes index from 17 to 19,8%, phagocytes activity of neutrophils – 10.1 – 11.4 per cent;– manifested stimulating effect on live weight and average daily gain from the use of probiotic «Evitaliya».

scholarly journals Productivity and resistance of pigs under the action of immunostimulants

2017 ◽  
Vol 19 (79) ◽  
Author(s):  
N. V. Chorniy ◽  
O. S. Machula ◽  
V. V. Voronyak ◽  
V. P. Lyasota ◽  
O. P. Reshetnichenko
Keyword(s):  
Blood Serum ◽  
B Lymphocytes ◽  
Live Weight ◽  
The Body ◽  
Control Group ◽  
Average Weight ◽  
Large White ◽  
Immunological Parameters ◽  
Humoral Factors ◽  
Experimental Group

The aim of the work was to study the influence of stimulant drugs – the regenerating biological stimulant (RBS) and Imunolac on the immunological state and productive qualities of piglets. RBS is a complex of organic compounds of animal tissue that stimulates nonspecific immunity and increases the protective functions of the body. Imunolac is a preparation of enzymatic hydrolysis of the cell wall of Lactobacillus, activating the cellular and humoral factors of non-specific animal resistance. To achieve this goal, the following tasks were set: to find out the microclimate condition and sanitary regime in the boxes in which the experimental animals were kept; – to study the influence of immunostimulating drugs on the growth and intensity of the test pigs, their safety; to study the dynamics of immunological parameters (circulating immune complex (CIC), T-and B-lymphocytes), the content of immunoglobulins (Jg G, Jg M and Jg A) while using RBS and Imunolac. The research was carried out in the pedigree plant «Stepnoy» of the Zaporozhye region on pigs of the Large white breed × Landras. Piglets of the control group were injected with 0.9% sodium chloride solution at a dose of 1 ml/head. During the experiment, the microclimate was monitored for temperature, relative humidity, air speed, carbon dioxide, ammonia, air contamination with microflora. Cellular indices were determined from the ratio of neutrophils to E. coli according to VG Gostivu, 1956, bactericidal activity of blood serum (BASK) – according to the method of O.V. Smirnova and TA. Kuzmenoy, 1966, lysozyme activity of blood serum (LASK) according to V. Dorofeychuk, 1968. The content of T lymphocytes was determined according to M. Jondal, 1973, B-lymphocytes – according to N.S. When piglets were grown at the temperature lower than 3,5–8 °C, humidity – by 5–8% higher, the parameters of NH3 and CO2 higher by 0.8–1.2%, the contamination microflora was twice as much as recommended by the sanitary norms the genetic productive potential of the animals is not fully realized, while – the highest daily average weight gain was in the pigs, which were injected intramuscularly with RBS growth stimulant. They exceeded the animals from the control group on the 20th and 30th days of the experiment – by 24.3% and 14.4%, live weight – by 15.3% (P < 0.05). The growth rate in the animals that were injected with imunolac was less expressed; the diseases with the symptoms of dyspepsia and bronchopneumonia were registered in 5–10% of the pigs from the experimental groups that received RBS and imunolac that is 10–12 times less as compared to the control group; in the pigs from the experimental group 1, the BASK was at the level of the average values of 56.52 ± 2.03%, from the experimental group 2 – 59.48 ± 1.80%, by 5.2% higher (P < 0.05); LASK indices in the animals of the experimental group tended to increase but the differences were not trustworthy (P < 0.5); the cell indices of resistance in the pigs that received RBS were higher: the phagocytic activity of blood serum – by 4.3% (P < 0.05), phagocytic number – by 9.7% (P <0.05); the highest concentration of immunoglobulin of class Jg G (21.82 ± 0.3 mg/ml) was revealed in the animals that received RBS preparations, the concentration of the above immunoglobulins was slightly below – 19.86 ± 0.18 mg/ml in the pigs that received imunolac (0–1). For immunoglobulins of class Jg M and Jg A, the fluctuations  between the experimental groups were within the limits of 2.23 ± 0.01 and 2.36 ± 0.09 mg/ml.

scholarly journals THE EFFECT OF «ARCUSIT» ON BIOCHEMICAL AND IMMUNOLOGICAL PARAMETERS BLOOD SERA IN SILVER-BLACK FOX (SILVER-BLACK FOX)

2021 ◽  
Vol 247 (3) ◽  
pp. 192-197
Author(s):  
I.I. Okulova ◽  
◽  
I.A. Domsky ◽  
Yu.A. Berezina ◽  
Z.N. Beltyukova ◽  
...  
Keyword(s):  
Experimental Data ◽  
Blood Serum ◽  
Bactericidal Activity ◽  
Lysozyme Activity ◽  
The Body ◽  
Phagocytic Index ◽  
Control Group ◽  
Immunological Parameters ◽  
Nonspecific Resistance ◽  
Experimental Group

The use of «Arkusit» at a dose of 20 μg / kg of body weight indicates a beneficial effect on the factors of nonspecific resistance of the silver-black fox. The concentration of alkaline phosphatase in the blood serum in the experimental group decreased by 1.8 times (P <0.001), the ALT index - by 1.2 (P <0.05). The concentration of glucose in the experimental group increased 2 times (P <0.05) compared with the control group. In animals of the experimental group, the lysozyme activity of blood serum increased 1.3 times (P <0.05), the OPR reaction and the phagocytic index - 1.4 times (P <0.05), the bactericidal activity of blood serum - 1.8 times (P <0.05). «Arcusit» stimulates the synthesis of gamma globulins, increases the opsonophagocytic, bactericidal activity of blood serum. Thus, the analysis of experimental data indicates that the drug «Arcusit» has a pronounced immunostimulating effect, providing the activation of factors of nonspecific resistance of the body of the silver-black fox.

scholarly journals Hereford and Simmental Cattle Breeds in Siberia: Implementation of the Adaptive and Productive Potential in the Cold Climate

2019 ◽  
Vol 8 (4) ◽  
pp. 9631-9636 ◽  
Keyword(s):  
Blood Serum ◽  
Average Daily Gain ◽  
Live Weight ◽  
Experimental Period ◽  
Cold Climate ◽  
The Body ◽  
Feed Conversion ◽  
Entire Study ◽  
Significant Difference ◽  
Meat Productivity

This study was aimed at studying the biological characteristics of the calves of the Hereford and Simmental breeds, and crosses of these breeds in Siberia. The article discusses the peculiarities of metabolism and utilization of nutrients, growth rate, meat productivity and quality, feed conversion in groups of calves up to 15.5 months of age due to the breed identity in the keeping conditions in light facilities and cold climate. Similarity has been noted in the parameters of gas-and-energy metabolism in Hereford and crossbred calves, including their seasonal dynamics. During the experimental period, a seasonal downward trend was noted in the heart rate of Hereford calves by 11.4 %, and respiration rate — by 33.8 %. In the Simmental peers, these figures decreased by 12 and 37.2 %, respectively, in hybrids — by 6.1 and 29 %. The seasonal decrease in the body temperature in Hereford and crossbred animals by 2.4 – 2.5 %, in Simmentals — by 1.3 %, and increased heat production by Hereford animals and their crosses — by 20.9 and 20.1 % (P<0.01), compared to the Simmental peers, were noted. In terms of the content of hemoglobin, Hereford calves (116.5 ± 3.6 g/l) and Hereford × Simmental hybrids (114.0 ± 5.1 g/l) tended to be superior to Simmental calves (103.5 ± 5.4 g/l). No significant difference in the erythrocytes count in the blood of calves was found between the groups. In all ages, Simmental calves were inferior to their Hereford and crossbred peers in terms of the content of total protein and albumin in the blood serum. By the content of globulins in the blood serum, no differences were found between the groups. The coefficients of nutrients digestibility due to balanced feeding was relatively high in all groups. Hereford × Simmental hybrids were superior to their Simmental counterparts by the organic matter digestibility by 3.0 % (P<0.01). The most significant difference in the live weight was observed between Simmental and crossbred calves (P<0.01). The average daily gain of the hybrids over the entire study period was greater by 25.6 and 15.2 % than that of purebred Simmental and Hereford calves. Accordingly, Hereford × Simmental calves had an advantage over Herefords in terms of the slaughtering weight by 5.4 %, and over Simmentals — by 22.1 %. The energy value of the meat of purebred Herefords and crossbred calves was higher by 8.4 % than in purebred Simmentals. The conclusion has been made about the prospects of using Herefords and their crosses with Simmentals for the sustainable development of beef cattle breeding in the conditions of Siberia.

The effectiveness of use of enterosorbent Shelltic Es when rearing of young pigs

2020 ◽  
pp. 3-11
Author(s):  
S. Grikshas ◽  
N. Kulmakova ◽  
K. Spitsyna ◽  
A. Dar’in ◽  
T. Mittelshtein
Keyword(s):  
Average Daily Gain ◽  
Live Weight ◽  
Feed Additives ◽  
The Body ◽  
Control Group ◽  
Internal Organs ◽  
Feed Digestibility ◽  
Young Pigs ◽  
Carcinogenic Effects ◽  
Experimental Group

Mycotoxins have been formed in feed are secondary metabolites of fungi and are quite stable substances that have teratogenic, mutagenic and carcinogenic effects. An effective way to combat mycotoxins in feed is the use of feed additives that adsorb toxins, prevent their absorption in the gastrointestinal tract of the animal and are excreted from the body. The infl uence of coconut enterosorbent Shelltic Es on fattening and meat qualities of young pigs has been studied. It has been found in the process of fattening that the highest feed digestibility was in pigs of the experimental group, in the diet of which enterosorbent has been added. The results of studies of the chemical composition and technological properties of pork have been provided. The positive eff ect of enterosorbent on precocity, absolute average daily gain of live weight and reduction of feed expenditures per 1 kg of gain has been revealed. In pigs from the experimental group the average thickness of the fat was higher and the area of the “muscle eye” was lower compared with animals of the control group, which indicates that higher rates of carcass yield have been obtained due to faster accumulation of fat tissue. The weight of internal organs of pigs indicates the intensity of metabolic processes in the body. In experimental animals the weight of the lungs was 0,1 kg lower, and the liver and heart were higher by 0,13 and 0,01 kg, respectively. Enterosorbent had no effect on the content of vitamins in the liver of pigs of the compared groups. The content of impurities of organochlorine toxicants and toxic elements in the meat and liver of animals of the experimental group was lower than that of control analogues. Therefore, the use of enterosorbent Shelltic Es promotes more active excretion of them from the body.

scholarly journals THE USE OF BIOSTIMULANT FOR INCREASING THE BODY WEIGHT GAIN OF CHICKENS

2020 ◽  
Vol 17 (35) ◽  
pp. 800-812
Author(s):  
Ilgiz DOLININ ◽  
George BAZEKIN ◽  
Evgeny SKOVORODIN ◽  
Almaz SHARIPOV ◽  
Ivan CHUDOV
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Live Weight ◽  
The Body ◽  
New Drugs ◽  
Natural Resistance ◽  
Control Group ◽  
Immunological Parameters

Poultry farming holds a special place in ensuring the products that the consumers demand, it provides the population with essential food products,such as eggs and meat,that contain vital micro and macronutrients, proteins, lipids, and vitamins. Therefore, the issues of rational, economically feasible feeding of meat poultry, namely broiler chickens, are an urgent task. It is also essential to find effective methods of their application in order to correct the natural resistance and immune and biological reactivity of birds. The purpose of this research is to study the effect of the biological stimulant-Nucleostim on the growth and development of chickens, hematological, and immunological parameters of the blood of birds.This Biostimulant is a purified bovine spleen extract containing at least 1 mg / ml of low molecular weight peptides (nucleotides and nucleosides) formed as a result of autolysis, using dry whey and diatomite as fillers. Onthe application ofNucleostim, the gain in live weight of chickens was increased by 9.7%. At the end of the experiment, the livability of the chicks of the experimental group treated with Nucleostimcame up to 88%, compared with the 72% of the control group. The use of biostimulant had a stimulating effect on the liver of chickens confirmed by the research results presented in the article, as well as contributed to the development of the thymus in the setting of general dystrophy. Thus, it improved chicklivability and increased body weight gain. The biological stimulant-Nucleostim as an adaptogenic, anabolic, and immunostimulatory agent is promising for finding new drugs that improve the health and productivity of poultry.

scholarly journals Use of water-alcohols treatment of medicinal plants under conditions modeling intoxication by lead and cadmium

2021 ◽  
pp. 80-88
Author(s):  
Yu. I. Koval ◽  
T. I. Bokova ◽  
A. F. Petrov
Keyword(s):  
Heavy Metals ◽  
Medicinal Plants ◽  
Blood Serum ◽  
Raw Materials ◽  
Antioxidant Properties ◽  
Live Weight ◽  
The Body ◽  
Laboratory Animals ◽  
Lead And Cadmium ◽  
Water Alcohol

The results of studying the effects of water-alcohol infusions of medicinal plants - rhizomes of thick-leafed incense (Bergenia crasslifolia L. Fritsch), dioica nettle leaves (Urtica dioca L.), burdock roots (Arctium lappa L.), and mother-and-leaf leaves - are presented. ordinary machichi (Tussilago farfara L.) on the organism of laboratory rats under conditions of short-term intoxication with heavy metals in doses of 25 mg of lead and 2.5 mg of cadmium per 1 kg of live weight. In the course of studies it was found that the effect of heavy metals on the body of laboratory animals is selective - the main “depot” of lead was bone tissue, and cadmium - the kidneys and liver. The addition of 1 ml of water-alcohol infusions from medicinal raw materials to the diet of rats as detoxicants caused a decrease in the level of lead in the animal organism to 6.32 times, cadmium to 3.46 times. The greatest detoxification ability was shown by infusions of the roots of burdock and leaves of nettle dioecious. Under the influence of elevated doses of lead and cadmium in laboratory animals there was an increase in heart mass by 40.34 % and spleen by 89.91 %, a decrease in the content of alkaline phosphatase in blood serum by 25.81 %. Water-alcohol infusions normalized the biochemical parameters of rat blood serum. Studies have shown that the infusions of rhizomes of thick-leafed frangipani, burdock roots, dioecious nettles and coltsfoot leaves with antioxidant properties can be the basis for the development of an effective herbal preparation used for the prevention and treatment of animals from intoxication with salts of heavy metals.

GROWTH AND DEVELOPMENT OF SIMMENTAL BULLS DEPENDING ON PROGENY

2021 ◽  
Vol 1 (1) ◽  
pp. 3-10
Keyword(s):  
Growth And Development ◽  
Average Daily Gain ◽  
Live Weight ◽  
The Body ◽  
Cattle Breeding ◽  
Dairy Cattle Breeding ◽  
Breeding Selection ◽  
Productivity Indicators ◽  
Body Parameters ◽  
Daily Gain

In dairy cattle breeding, selection and breeding work is widely used in order to transfer the pedigree qualities of parents to the offspring and obtain highly productive young animals. In this regard, in the conditions of «Enbek» LLP in the Akmola region, the growth and development of young Simmental breed depending on the origin was studied. Live weight of Litera line young animals at birth was 33.4 kg, at the age of 6 months-174.9, 12 months-251.8, 18 months-387.1 kg, respectively, Wildfang bull 32.0 kg, 165.5 kg, 251.3 kg, 378.6 kg. The average daily gain between the ages of birth and 6 months was increased. With age, the body parameters, height at the withers, increased from 104.3 cm and 103.5 cm to 125.4 cm and 123.9 cm, respectively, from 6 months to 18 months of young animals. According to the physique indices, we can say that the young Simmental breed is balanced. Only some deviations of the leggy index are observed from the optimal indicators. The index of legginess decreases with age by 7.7%, with indicators of 6 months – by 57%, at the age of 18 months-by 49.3%. The extension index for the period from 6 to 18 months increased by 10.5%, respectively, for 6 months-by 103.3%, for 18 months-by 113.8%. With age and an increase in live weight, the body of young animals lengthens, its width increases, the animal becomes deeper and relatively long-legged. Depending on the origin, we suggest using the Litera bull line, taking into account the growth and development of young animals, and the productivity indicators of bulls.

scholarly journals REASIL HUMICVET AND REASIL HUMIC HEALTH SUPPLEMENTS BASED ON HUMIC ACIDS IN THE DIETS OF DAIRY CALVES

2021 ◽  
Vol 6 (1) ◽  
pp. 64-70
Author(s):  
Andrei Frolkin ◽  
Haidar Valitov ◽  
Aleksandr Varakin ◽  
Valentina Kornilova
Keyword(s):  
Blood Serum ◽  
Live Weight ◽  
Mineral Elements ◽  
The Body ◽  
Control Group ◽  
Liquid Form ◽  
Daily Growth ◽  
Black And White ◽  
Significant Difference ◽  
Experimental Group

The purpose of the research is to increase the effectiveness of the supplement Reasil on the growth of milk-fed calves. For the scientific and economic experience, three groups of calves were formed (control, 1 and 2 experi-enced). Groups of animals of 10 heads were formed according to the principle of analogues. The indicators of live weight, growth and blood of calves were studied after Reasil use in a diet: Reasil HumicVet as a liquid form, and Reasil Humic Health – reduced to powder. In the experiment, animals of a black-and-white breed were used. The Reasil feeding in the diet contributed to an increase in the live weight of milk-fed calves in the 1-st and the 2-nd experimental groups at two months of age by 5.65 and 5.48 kg (or by 7.4 and 7.2%), respectively, compared to the indicator of the control group analogues. The average daily growth of calves of the experimental groups exceeded this indicator of control animals by 96 and 82 g, respectively. The blood of calves of the 1st and 2nd experimental groups, showed that hematoglobin was higher by 15.7 and 11.4%, red blood cells – by 16.5 and 15.1%, and the alkaline reserve – by 5.2%, compared with blood of calves from the control group, which indicates the activation of metabolic processes in the body. The total protein amount in the blood serum of animals from the experimental groups increased by 8.4 and 5.9% respectively, compared to the tests of calves from the control group. The albu-min content of animals of the 1st experimental group tested was higher by 5.3%; from the 2nd experimental group there was no significant difference compared to the control. The number of gamma-globulins in the blood of ani-mals of the experimental groups increased, which indicates an increase in defense reaction of animals. The con-tent of calcium in the blood serum of calves from the experimental groups was higher by 8.3 and 5.9%, phosphorus – by 4.8 and 2.4%, which indicates a more effective use of these mineral elements.

scholarly journals Influence of the supplement «Press-Acid» on protein-mineral metabolism and resistance of piglets

2018 ◽  
Vol 20 (83) ◽  
pp. 320-324 ◽  
Author(s):  
N.V. Chеrniy ◽  
E.V. Matsenko ◽  
Yu.A. Shchepetilnikov ◽  
Yu. V. Maslak ◽  
O.S. Machula ◽  
...  
Keyword(s):  
Blood Serum ◽  
Mineral Metabolism ◽  
The Body ◽  
Control Group ◽  
Immunological Parameters ◽  
Oxidative Reaction ◽  
Experimental Animals ◽  
Growth Energy ◽  
First Time ◽  
Experimental Group

The aim of this study was to determine the effect of supplement «Press-Acid» on some parameters of mineral and protein metabolism and resistance of piglets. The study was done in condition «Meta» on two groups of piglets of the F-1 (BWхL) genotype. There were determined indexes of bacterial and lysocim activity of blood serum, calcium and phosphorus in piglets at the age of 21–30–45–75 days. Effect of supplement on the growth rate, morbidity and safety of pigs were revealed. We used hygienic, zootechnical, hematological, biochemical, immunological and statistical methods of analysis. The influence of «Press-Acid», which consist of formic, lactic, citric and fumaric acids, was established for the first time. The concentration of calcium in blood serum of experimental group of piglets were lower than in animals of control group. The level of phosphorus increased in blood serum of experimental animals on 11.83% (30 day), on 3.74% (45%), on 17.65% (75 day) respectively. Concentration of hemoglobin and the amount of erythrocytes increased on 11.8% and on 1.82% (30 day) in animals that feed the supplement. There were established the increase of viability of the pigs with gastro-intestinal diseases which were given the supplement in comparison with that, who did not feed it. Severity of diseases was determined using the Melenberg coefficient which did not higher than 1.2–2.4 score, it was lower on 6,0–9,3 unit than in control group. Using the supplement allowed to increase the intensity of growth of piglets by 3.7% (45 day) and 9.4% (75 day) respectively. Concentration of total protein, albumines and globulins increased on 8.66%, 9.90%, 7.3% respectively. The activity of alaninaminotransphaerasae in the blood serum of experimental animals were lower on 3.45% than in control piglets. Lysocym and bacterial activity of blood serum were higher in experimental group of piglets. Feeding piglets with addition supplement Press Acid promotes higher grow rates in experimental animals, that can be explained increases of oxidative-reducing processes in them organism. Feeding piglets with acidifier «Press-Acid», «Nifulin», zinc oxide, probiotics «Lactisan Complex» promotes growth energy, increase of morphological, biochemical and immunological parameters which indicates a higher level of oxidative reaction in the body. A low coefficient of Melenberg is recorded in the piglets at the age of 1 day. Safety was within 92.1–97.0%. That indicates a more successful elimination of complexes of protein, mineral substances, humoral protection in blood of experimental group of animals.

scholarly journals Assessment of macrocyclic lacton group products for ectoparasitosis of carp

2020 ◽  
Vol 22 (98) ◽  
pp. 16-21
Author(s):  
Yu. V. Loboiko ◽  
Ye. O. Barylo ◽  
B. S. Barylo
Keyword(s):  
Immune System ◽  
T Lymphocytes ◽  
Self Regulation ◽  
The Body ◽  
Macrocyclic Lactones ◽  
Emamectin Benzoate ◽  
Immunological Parameters ◽  
Humoral Factors ◽  
Industry Group ◽  
Antiparasitic Drugs

The material for the study were Lubin carp of one year old spontaneously invaded by the ectoparasites Lernaea cyprinacea and Dactylogyrus vastator. For the experiment we used drugs: "Brovermectin-granulate" (development of “BFP” serial production; 1 g of the preparation contains: active substance (ADR) ivermectin – 3.5 mg; tocopherol acetate (20 mg) and Emamectin benzoate (manufactured by King Quenson Industry Group; 1 g of preparation contains ADR emamectin benzoate (50 mg). Analyzing morphological, biochemical and immunological parameters of blood and organs of fish, it is possible to state that the fact that the anti-parasitic drugs “Brovermectin granulate” and “Emamectin benzoate” has a pronounced antiparasitic effect, normalizing the homeostasis of the body. The results obtained showed significant fluctuations in the number neutrophils, eosinophils and lymphocytes. In ectoparasites infested of fishes used for macrocyclic lactones, y leukocyte formula sharply increases the percentage of rod-shaped neutrophils and at the same time decreases the proportion of lymphocytes. At the same time, there is an increase in the number of eosinophils that perform the function of protecting the body of fish from parasites. Eosinophilia, as in the higher vertebrates, is one of objective indicators of allergy (sensitization) of the body, nature the course of inflammatory processes. The results obtained indicate a decrease in the production of total T-lymphocytes are cells that play a key role in the immune system protection in the body of carp for damage by ectoparasites. In analyzing the above data, attention is drawn to the lower functional the activity of the blood T-lymphocyte system in ectoparasites infested with fish, than those given antiparasitic drugs. From this it follows that the ability of the blood lymphocytes of the fish to which the drugs from the group were given of macrocyclic lactones, before pathogen binding and production of antigens the antibodies that neutralize them are much higher than the fish affected ectoparasites. The immune system in fish provides self-regulation through direct contact of cells (macrophages, neutrophils, cytotoxic T-lymphocytes) as well as due to humoral factors (lysozyme, complement). The use of drugs from the group of macrocyclic lactones promotes the release of infested fish from ectoparasites with the following normalization of their life, increase of immune status and resistance.

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