scholarly journals Antianemic action of the iron (IV) clathrochelate complexes

2020 ◽  
Vol 11 (3) ◽  
Author(s):  
V. B. Dukhnitsky ◽  
I. M. Derkach ◽  
M. O. Plutenko ◽  
I. O. Fritsky ◽  
S. S. Derkach
Keyword(s):  
Active Substance ◽  
Mass Fraction ◽  
New Drugs ◽  
Deficiency Anemia ◽  
Control Group ◽  
Hemoglobin Content ◽  
Contagious Diseases ◽  
Experimental Group ◽  
Group 1 ◽  
Clathrochelate Complexes

Anemia is one of the most common non-contagious diseases of pigs. Modern antianemic drugs have several drawbacks, so finding new drugs is a pressing issue. We previously reported the results of preclinical studies of iron in rare high valence IV. This allowed us to determine, supplement, and generalize the data on clinical studies of the new drugs with the active substance iron (IV) clathrochelate. Therefore, we studied its antianemic effect on piglets. Experiments were carried out on piglets-analogues neonates, which were divided into three groups: control and two experimental groups. Piglets were kept with sows on suckling. For the purpose of prevention of iron deficiency anemia, the traditional solution of iron dextran was administered once intramuscularly to piglets of I control group. The aqueous solution of iron (IV) clathrochelate complexes was administered once intramuscularly to piglets of II experimental group. Iron (IV) clathrochelate complexes were dissolved in a solvent of rheopolyglucin and administered once intramuscularly to piglets of III experimental group. 1 mL of test solutions contained 100 mg of active substance. The investigative material were the samples of blood and serum of piglets, their liver and spleen. The experiment lasted during a 30-day period since the birth of the piglets. According to the results of the experiments, iron (IV) clatrochelate complexes which were dissolved in water for injection and rheopolyglucin had higher antianemic activity compared to the control. This is evidenced by the dynamics of probable changes in the number of erythrocytes, hemoglobin content and hematocrit, iron content in serum and its mass fraction in the blood, liver and spleen of piglets. The effectiveness of the action of iron (IV) clatrochelate complexes is demonstrated by the full supply of piglets with iron and its higher bioavailability.

scholarly journals Research antianemic action of the iron (IV) clathrochelate complexes on the sickling piglets

2020 ◽  
Vol 22 (99) ◽  
pp. 107-115
Author(s):  
V. B. Dukhnitskyi ◽  
I. M. Derkach ◽  
S. S. Derkach ◽  
I. O. Fritsky ◽  
M. O. Plutenko ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Active Substance ◽  
New Drugs ◽  
Deficiency Anemia ◽  
Control Group ◽  
Hemoglobin Content ◽  
Experimental Group ◽  
Group 1 ◽  
Clathrochelate Complexes

A lot of antianemic drugs for animals are presented on the modern pharmaceutical market of veterinary medicine, but they have several drawbacks. So finding new drugs with goal to treat ill animals by anemia and to prevent the iron deficiency anemia is a pressing issue. We previously reported the results of preclinical studies of iron in rare high valence IV. This allowed us to determine, supplement, and generalize the data on clinical studies of the new drugs with the active substance iron (IV) clathrochelate. Therefore, the article presents the results of studies of its antianemic effect on sickling piglets. Experiments were carried out on piglets-analogues neonates, which were divided into three groups: control and two experimental groups. Piglets were kept with sows on suckling. For the purpose of prevention iron deficiency anemia the traditional solution of iron dextran was administered once intramuscularly to piglets of I control group. The aqueous solution of iron (IV) clathrochelate complexes was administered once intramuscularly to piglets of II experimental group. Iron (IV) clathrochelate complexes was dissolved in a solvent of rheopolyglucin and administered once intramuscularly to piglets of III experimental group. 1 mL of test solutions contained 100 mg of active substance. The investigative material were the samples of blood and serum of piglets, their liver and spleen. The experiment lasted during a 30-day period since birth of piglets. According to the results of the experiments, iron (IV) clatrochelate complexes which was dissolved in a water for injection and rheopolyglucin had higher antianemic activity compared to the control. This is evidenced by the dynamics of probable changes in the number of erythrocytes, hemoglobin content and hematocrit, Iron content in serum and its mass fraction in the blood, liver and spleen of piglets. The effectiveness of the action of iron (IV) clatrochelate complexes is explained by the full supply of piglets with iron and its higher bioavailability.

scholarly journals Dynamics of Morphological Indicators of Blood of Piglets under the Influence of Iron Clathrochelate Complex and Cyanocobalamin

2021 ◽  
Vol 11 (4) ◽  
pp. 663-669
Author(s):  
Iryna Derkach ◽  
Volodymyr Dukhnitsky ◽  
Serhii Derkach ◽  
Vitalii Lozoviy ◽  
Vasyl Kostrub ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Control Group ◽  
Hemoglobin Content ◽  
Blood Indices ◽  
Contagious Diseases ◽  
Intramuscular Injections ◽  
Current Task ◽  
Suckling Piglets

Iron deficiency anemia is one of the most common non-contagious diseases of piglets. Veterinary antianemic drugs have several drawbacks, so finding new medicines is an important current task for scientists. Therefore, the present study investigated the antianemic effect of iron (IV) clathrochelate in the organism of piglets. The subsequent studies included the exploration of its antianemic actions, particularly in combination with cyanocobalamin when this combination was administered to sows for prophylaxis in piglets. The experiment was carried out on 30 suckling piglets during the period of their detention with sows. According to the method of analogue groups, two groups of control (I) and experimental (II, each containing 15 animals) were formed and they were studied for 30 days. The piglets from five sows (three from each) were selected for the experimental group. During the pregnancy of these sows, 10 ml of 10% solution of iron (IV) IV clathrochelate and solution of cyanocobalamin were injected intramuscularly twice 7 and 14 days before their expected farrowing. For prevention of iron deficiency anemia, the traditional solution of iron dextran was administered once intramuscularly to piglets of the control group. The investigative material included the blood samples of piglets considering the dynamics of probable changes in the number of erythrocytes, hemoglobin content and hematocrit, and other morphological indicators and blood indices of piglets. The dynamics of changes in erythrocyte count, hemoglobin content, hematocrit, leukocytes and platelets, indices of blood almost did not differ from the dynamics of these values when using only 10% solution of iron (IV) clathrochelate for pregnant sows. The proposed scheme for the prophylaxis of iron deficiency anemia in piglets, involving simultaneous intramuscular injections of IV clathrochelate and cyanocobalamin to pregnant sows, is somewhat inferior to the previous preventive measures, which included only the intramuscular injections of iron (IV) IV clathrochelate, but it can be recommended as highly effective.

scholarly journals Hemoglobin content, hematocrit and morphological parameters of blood of piglets under the influence of iron preparations

2021 ◽  
Vol 23 (101) ◽  
pp. 8-14
Author(s):  
V. B. DuKhnitskyi ◽  
I. M. Derkach ◽  
S. S. Derkach ◽  
I. O. Fritsky ◽  
M. O. Plutenko ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Blood Cells ◽  
The Body ◽  
Deficiency Anemia ◽  
Normative Values ◽  
Control Group ◽  
Morphological Parameters ◽  
Hemoglobin Content ◽  
Experimental Group

Hypoplastic anemia is a disease that is associated with a decrease in the number of red blood cells and / or hemoglobin per unit volume of blood due to hematopoietic disorders and is manifested by changes in metabolism and growth retardation. Particular attention was paid to changes in the body of piglets of the experimental group compared with the control in the probable period of manifestation of iron deficiency anemia. The uniqueness of the chemical structure of iron (IV) clatrochelate allowed us to assume that intramuscular administration of a solution of this substance to sows will provide the necessary need for iron during the first months of life of piglets. The influence of the proposed scheme of prevention of this pathology on the further development of young pigs was analyzed. The results of the study of erythrocyte count, hemoglobin content and hematocrit were scientifically significant, because the gradual decrease in these indicators after the birth of piglets is a physiologically determined phenomenon for animals of this species. The aim of our study was to evaluate the effectiveness of the use of Iron (IV) clatrochelate in pregnant sows in order to prevent iron deficiency anemia in piglets and to determine its effect on hemoglobin content, hematocrit and morphological parameters of piglets' blood. To achieve this goal, 2 groups of newborn piglets-analogues were formed during their retention with suckling sows – control and experimental, 15 animals in each. The experiment lasted 60 days. Piglets from the experimental group were selected from sows who were injected 10 ml 10 % Iron (IV) clatrochelate solution twice intramuscularly during pregnancy. The results of the studies show that the content of hemoglobin in the blood of piglets of the experimental group was the same as in animals of the control group at 1 and 60 days of life, and 1.1–1.3 times lower in other periods of the study; hematocrit - was the same on the first day of life and 1.3–1.9 times lower in other study periods. Quantitative indicators of blood cells of piglets of the control and experimental groups did not exceed the normative values, but the number of erythrocytes in the blood of piglets of the experimental group was probably lower than the control indicator at 5, 9 and 30 days of life.  Therefore, a double injection of 10 % Iron (IV) clatrochelate solution into pregnant sows 14 and 7 days before the expected farrowing provides a preventive effect on iron deficiency anemia in piglets born to them.

INFLUENCE OF STOCK HOUSE LIGHT ON DAIRY PRODUCTIVITY OF COWS

2020 ◽  
Keyword(s):  
Blood Serum ◽  
Physiological State ◽  
Light Level ◽  
Inorganic Phosphorus ◽  
Control Group ◽  
Hemoglobin Content ◽  
Milk Productivity ◽  
Reproductive Ability ◽  
The Cost ◽  
Experimental Group

The article is devoted to the solution of an urgent problem- influence of different lighting modes on the dairy productivity of cows. 2 groups of cows with 20 heads each were formed. In control group, light in the cowshed was 50-75 Lux for a light period of 7.5 h in January to 16.5 h in June, and in experimental group - 150-200 Lux and 16 h, respectively. It was found that the intensity and duration of illumination affects physiological state, reproductive ability and milk productivity of cows. In the experimental group of cows, compared with the control group, hemoglobin content in blood increased by 4.6% (P < 0.01), red blood cells - by 20.6% (P < 0.05), total protein - by 11.2% (P < 0.001), glucose - by 39.1% (P < 0.05). There was a tendency to increase the total calcium and inorganic phosphorus in blood serum of cows of the experimental group. The level of alkaline phosphatase in blood serum of cows in the control group was 71.5% (P < 0.01) higher than that of cows in the experimental group. Milk yield per 1 cow in the experimental cowshed was 433 kg more than in the control. The cost of 1 kg of milk in the experimental group was 0.94 rubles lower, and the profitability of milk production and sales is 9.42% higher than in the control group. To increase the milk productivity of cows, it is recommended to increase light level in barns for tethered keeping to 150-200 Lux, with the duration of lighting in the winter and transition periods of year up to 16 hours per day.

scholarly journals The CARESSES Randomised Controlled Trial: Exploring the Health-Related Impact of Culturally Competent Artificial Intelligence Embedded Into Socially Assistive Robots and Tested in Older Adult Care Homes

2021 ◽  
Author(s):  
Chris Papadopoulos ◽  
Nina Castro ◽  
Abiha Nigath ◽  
Rosemary Davidson ◽  
Nicholas Faulkes ◽  
...  
Keyword(s):  
Older Adult ◽  
Controlled Trial ◽  
Control Group ◽  
Culturally Competent ◽  
Adult Care ◽  
Assistive Robots ◽  
Sf 36 ◽  
Randomised Controlled ◽  
Experimental Group ◽  
Group 1

AbstractThis trial represents the final stage of the CARESSES project which aimed to develop and evaluate a culturally competent artificial intelligent system embedded into social robots to support older adult wellbeing. A parallel group, single-blind randomised controlled trial was conducted across older adult care homes in England and Japan. Participants randomly allocated to the Experimental Group or Control Group 1 received a Pepper robot for up 18 h across 2 weeks. Two versions of the CARESSES artificial intelligence were tested: a fully culturally competent system (Experimental Group) and a more limited version (Control Group 1). Control Group 2 (Care As Usual) participants did not receive a robot. Quantitative outcomes of interest reported in the current paper were health-related quality of life (SF-36), loneliness (ULS-8), and perceptions of robotic cultural competence (CCATool-Robotics). Thirty-three residents completed all procedures. The difference in SF-36 Emotional Wellbeing scores between Experimental Group and Care As Usual participants over time was significant (F[1] = 6.614, sig = .019, ηp2 = .258), as was the comparison between Any Robot used and Care As Usual (F[1] = 5.128, sig = .031, ηp2 = .146). There were no significant changes in SF-36 physical health subscales. ULS-8 loneliness scores slightly improved among Experimental and Control Group 1 participants compared to Care As Usual participants, but this was not significant. This study brings new evidence which cautiously supports the value of culturally competent socially assistive robots in improving the psychological wellbeing of older adults residing in care settings.

Effects of Dietary Addition of Linseed Oil on the Content of Polyunsaturated Fatty Acids in Egg Yolk of Gallus domestiaus

2021 ◽  
Vol 15 (4) ◽  
pp. 565-570
Author(s):  
Suhu Duan ◽  
Zaiqiang Li ◽  
Zhenzhen Fan ◽  
Mengran Qin ◽  
Xiaoxue Yu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gas Chromatography ◽  
Polyunsaturated Fatty Acids ◽  
Theoretical Basis ◽  
Linseed Oil ◽  
Egg Yolk ◽  
Free Food ◽  
Control Group ◽  
Experimental Group ◽  
Group 1

In order to study the effect of dietary supplement of linseed oil on polyunsaturated fatty acids (PUFAs) in egg yolk of Gallus domestiaus, total 160 healthy Gallus domestiaus of 26-week old were randomly selected and divided into 4 groups, each of which included 40 chickens fed outdoors with an area of 63 m2 and free food and drinking water. The control group (CK) was fed the basic diet, and the experimental group was added 1, 3 and 5% of linseed oil in the fundamentals of diet (experimental group 1, 2 and 3, abbreviated as P1, P2, P3), respectively. The content of PUFA and the value of n-6 PUFA and n-3 PUFA in egg yolk were determined by gas chromatography with 24 eggs randomly selected in each group after 10th, 25th and 40th days of the commence of the experiment. We found that the levels of α-linolenic acid (C18:3n3, ALA) and docosahexaenoic acid (C22:6n3, DHA) in egg yolk were clearly higher than the CK when 3% linseed oil or 5% linseed oil were added in the diet during the three experiment periods, in which the contents of linoleic Acid (18:2n6c, LA) and arachidonic acid (C20:4n6, ARA) in egg yolk differ little between P1, P2 and P3 and the CK while the value of n-6 PUFA and n-3 PUFA in egg yolk of the P2 and P3 groups decreased significantly. The comprehensive comparisons suggested that the content of C18:3n3 and C22:6n3 in egg yolk could be clearly increased in the P2 while the value of n-6 PUFA and n-3 PUFA decreased. This study provides theoretical basis for the production of functional eggs enriched with C22:6n3 and C18:3n3.

Second language articulatory training and computer-generated feedback in L2 pronunciation improvement

2016 ◽  
Vol 167 (2) ◽  
pp. 190-209
Author(s):  
Meisam Rahimi
Keyword(s):  
Second Language ◽  
Generalization Test ◽  
Control Group ◽  
Acoustic Feedback ◽  
Computer Based ◽  
Group 2 ◽  
Manner Of Articulation ◽  
Esl Learners ◽  
Experimental Group ◽  
Group 1

This paper investigates the efficacy of articulatory training and acoustic feedback on Persian L2 learners’ production of English segmental (/ɒ/). A sample of 30 Persian ESL learners was recruited- 10 learners were randomly assigned to the experimental group 1, 10 to the experimental group 2, and 10 to the control group. Over a five-week period, the experimental group 1 received training on the manner of articulation of the segment, the experimental group 2 received acoustic-articulatory training and was exposed to CALL software for receiving feedback, and the control group was only exposed to auditory input. The groups were given a pretest, an immediate posttest, and a generalization test. The results of the study showed a significant improvement in the performance of the participants in both the posttest and the generalization test in the experimental group 2. These findings suggest the inefficiency of the mere knowledge of the manner of articulation of the segment and lend support to the feasibility of using acoustic features of sounds and computer-based, learner-centred programs for second language segmental acquisition.

scholarly journals Education and Music Culture in the Context of Web 2.0

2021 ◽  
Vol 16 (10) ◽  
pp. 96
Author(s):  
Vira Revenko
Keyword(s):  
Music Education ◽  
Web 2.0 ◽  
Subjective Assessment ◽  
Control Group ◽  
Academic Anxiety ◽  
Musical Works ◽  
Group 2 ◽  
Deep Integration ◽  
Experimental Group ◽  
Group 1

Total digitalization of culture requires the extensive integration of Web 2.0 ser-vices and capabilities into music education. The penetration of digital technologies is not reduced to the technologies for fixing and distributing musical works or the means of their broadcasting but also dramatically transforms the process of creat-ing musical works. Web 2.0 offers a new distributed creativity culture and pro-vides musicians with specific opportunities to work and distribute creative prod-ucts. The study is devoted to the integration of music education and the services and opportunities that Web 2.0 provides to the mass audience (free specialized and non-specialized services), its impact on the quality of music education, as well as on the most important psychological parameters of students of music uni-versities. The study involved 150 students of R. Glier Kyiv Municipal Academy of Music (Kyiv, Ukraine); there were three groups of 50 participants: two exper-imental groups and a control one. In Experimental Group 1, training was partially integrated with Web 2.0 services; in Experimental Group 2, there was a more complete and structured integration. Based on the results of semester training and the objective test scores, a significant increase in the results of experimental groups was observed (an increase by 1.3 points in Group 1 and 2.84 points in Group 2 on a 5-point scale); Group 2 demonstrated a more significant improve-ment. The subjective assessment of the level of involvement, motivation and anx-iety showed a statistically significant decrease in academic anxiety in the experi-mental groups (2.99 and 2.01 compared to 3.98 in the control group, respective-ly) and a statistically significant increase in motivation and involvement in the group with deep integration of Web 2.0 services (Experimental Group 2). The hypothesis of the study that deep integration of Web 2.0 services and capabilities into music education will increase objective academic results, motivation and stu-dent involvement has been fully confirmed. It has also been revealed that it helps students reduce academic anxiety. The research results can be used as a basis for further research and in the course of the development of music education curricu-la based on online learning, mobile learning and the integration of music learning into a digital environment.

scholarly journals Pengaruh Penggunaan Buah Alpukat dan Virgin Coconut Oil (VCO) Terhadap Perawatan Rambut Rontok

2020 ◽  
Vol 11 (02) ◽  
pp. 74
Author(s):  
Syannaz Rizka Usman ◽  
Yuliana Yuliana
Keyword(s):  
Hair Loss ◽  
Coconut Oil ◽  
Primary Data ◽  
Control Group ◽  
Research Subjects ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Experimental Group ◽  
Group 1

Excessive hair loss will cause baldness. It can will influence someone’s confidence. that is why, hair loss treatment is needed to be done. One of them is by using avocados and VCO. They have good function to stimulate hair growth and make them healthier. This study aims to analyze the effect of avocados and VCO toward hair loss treatment. The research was done by observing the mount of hair loss everyday. this study was conducted with a quasi-experimental method with a quasi exsperiment to explain the influence of using avocados and VCO on the treatment of hair loss. The research subjects were a collection of women who lived in the Parak Laweh area of ​​Lubuk Begalung subdistrict which improved hair loss at the level of 40-100 strands per day. The sample in this study amounted to 12 people used by the technique of taking documentation and interviews. This study consisted of 4 different groups, namely the control group (X0), experimental group 1 (X1), experimental group 2 (X2), and experimental group 3 (X3).The data gathered is primary data. It is directly taken from samples that fill in the research format provided. Data analysis using analysis of variance (anava) and continued with Duncan test, the results of this study show a significant difference in the indicator of the amount of hair detached from the scalp with the number of strands of hair falling after treatment in the control group (X0) (80.50), experimental group 1 (X1) (60.50), experimental group 2 (X2) (58.83) and experimental group 3 (X3) (58.67). So it can be said that for the indicator of the amount of hair loss in the experimental group did not show a statistically significant difference, but there was a significant difference in the treatment of hair loss in the control group. Keywords: hair loss, avocados, VCO

scholarly journals Does Unilateral Thyroid Cancer Affect The Malignant Risk Of Contralateral Thyroid Nodules?-A Retrospective Cohort Study

2020 ◽  
Author(s):  
Huan Liu ◽  
Jun Jin ◽  
Qiao Chen ◽  
Zhongmin Li
Keyword(s):  
Clinical Trial ◽  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Control Group ◽  
Clinical Trial Registration ◽  
Significant Difference ◽  
Group 2 ◽  
Experimental Group ◽  
Group 1

Abstract BackgroundThe incidence of thyroid nodules increased significantly, but the mortality rate of thyroid cancer remained stable or even decreased. However, surgical treatment of thyroid nodules is more aggressive, including the number and scope of surgery. the purpose of our study was to evaluate whether unilateral thyroid nodules affect the malignancy risk of contralateral thyroid nodules. Methods We conducted a retrospective study on all patients with thyroid nodules in a tertiary hospital within one year. Unilateral and bilateral thyroid nodules were the control group and the experimental group, respectively. Based on the TI-RADS grades, the experimental group and the control group were divided into two subgroups. We used chi-square test or Fisher's exact test to evaluate whether there were statistical differences in the incidence and pathological types of thyroid cancer between the experimental group and the control group. Results Our study showed that there was no significant difference in malignant risk between the experimental group 1 and the control group 1, and the experimental group 2 and the control group 2 (20%vs35%, p=0.724, 63.16%vs76.32%, p=0.297, respectively). Both the a-side thyroid of the experimental group and the control group were papillary thyroid carcinoma, including micropapillary thyroid carcinoma, and there was no difference in the proportion of micropapillary thyroid carcinoma (p = 0.200, 0.620, respectively). Conclusions There is no evidence that bilateral thyroid nodules affect each other in terms of malignant risk, that is, in bilateral thyroid nodules, unilateral thyroid cancer does not change the malignant risk of contralateral thyroid nodules.This study has been registered with the Chinese Clinical Trial Registry, clinical trial registration number: ChiCTR2000038611, registration time: 2020-09-26.

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