The Role of Angiotensin Receptor Blockers in Cardiovascular Protection Beyond Blood Pressure Control

2006 ◽  
Vol 3 (2) ◽  
pp. 37-39
Author(s):  
Prakash Deedwania
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Angiotensin Receptor Blockers ◽  
Pressure Control ◽  
Angiotensin Receptor ◽  
Cardiovascular Protection ◽  
Receptor Blockers

scholarly journals Blood Pressure Control: Stroke and Stroke Prevention

2005 ◽  
Vol 6 (1_suppl) ◽  
pp. S8-S11
Author(s):  
Hans-Christoph Diener
Keyword(s):  
Blood Pressure ◽  
Stroke Prevention ◽  
Antihypertensive Drugs ◽  
Angiotensin Receptor Blockers ◽  
Antihypertensive Agents ◽  
Pressure Control ◽  
Angiotensin Receptor ◽  
Risk Of Death ◽  
Pressure Lowering ◽  
Receptor Blockers

Hypertension is the most important modifiable risk factor for primary and secondary stroke prevention. All antihypertensive drugs are effective in primary prevention: the risk reduction for stroke is 30—42%. However, not all classes of drugs have the same effects: there is some indication that angiotensin receptor blockers may be superior to other classes of antihypertensive drugs in stroke prevention. Seventy-five percent of patients who present to hospital with acute stroke have elevated blood pressure within the first 24—48 hours. Extremes of systolic blood pressure (SBP) increase the risk of death or dependency. The aim of treatment should be to achieve and maintain the SBP in the range 140—160 mmHg. However, fast and drastic blood pressure lowering can have adverse consequences. The PROGRESS trial of secondary prevention with perindopril + indapamide versus placebo + placebo showed a decrease in numbers of stroke recurrences in patients given both active antihypertensive agents, more impressive for cerebral haemorrhage.There were also indications that active treatment might decrease the development of post-stroke dementia.

Angiotensin Receptor Blockers Are Not Just for Hypertension Anymore

Physiology ◽  
2021 ◽  
Vol 36 (3) ◽  
pp. 160-173 ◽  
Author(s):  
Juan M. Saavedra
Keyword(s):  
Blood Pressure ◽  
Immune Responses ◽  
Metabolic Disorders ◽  
Angiotensin Receptor Blockers ◽  
Pressure Control ◽  
Coagulation Cascade ◽  
Angiotensin Receptor ◽  
Age Related ◽  
Injury Mechanisms ◽  
Receptor Blockers

Beyond blood pressure control, angiotensin receptor blockers reduce common injury mechanisms, decreasing excessive inflammation and protecting endothelial and mitochondrial function, insulin sensitivity, the coagulation cascade, immune responses, cerebrovascular flow, and cognition, properties useful to treat inflammatory, age-related, neurodegenerative, and metabolic disorders of many organs including brain and lung.

Sign in / Sign up

Export Citation Format

Share Document