scholarly journals Non-coronary Interventions: An Introduction to Peripheral Arterial Interventions

2016 ◽  
Vol 11 (2) ◽  
pp. 128
Author(s):  
Brock Cookman ◽  
Suhail Allaqaband ◽  
Tonga Nfor ◽  
◽  
◽  
...  
Keyword(s):  
Strong Relationship ◽  
Ageing Population ◽  
Peripheral Vascular ◽  
Endovascular Interventions ◽  
Cardiovascular Morbidity And Mortality ◽  
Vascular Beds ◽  
Peripheral Arterial ◽  
Peripheral Artery Diseases ◽  
Broad Understanding

With an ageing population, the burden of peripheral artery diseases (PADs) is increasing. The treatment of these diseases has largely been performed by interventional radiologists, vascular surgeons and interventional cardiologists. Due to the strong relationship between PAD and overall cardiovascular morbidity and mortality, cardiologists need to play a greater role in the management of PAD. The physician who cares for the patient with peripheral vascular disease should have a broad understanding of atherosclerotic disease involving all vascular beds. Endovascular interventions play a major role in relieving symptoms and reducing morbidity related to PAD, but long-term optimal medical treatment is an essential determinant of prognosis. This paper reviews current endovascular/percutaneous interventions for PAD.

scholarly journals Peripheral Vascular Stents in Clinical Practice

1970 ◽  
Vol 1 (1) ◽  
pp. 81-83
Author(s):  
GMM Hossain
Keyword(s):  
Treatment Options ◽  
Vascular Diseases ◽  
Primary Treatment ◽  
Major Advance ◽  
Peripheral Vascular ◽  
Endovascular Stents ◽  
Vascular Stents ◽  
Endovascular Interventions ◽  
Arterial Lesions ◽  
Peripheral Arterial

The development of endovascular stents has been a major advance in the treatment of vascular diseases. Endovascular interventions are quickly replacing bypass surgery and endarterectomy as the primary treatment options for stenotic peripheral arterial lesions. Studies using stents in the carotid and iliac arteries have shown acceptable clinical outcome. In this review the basic aspects of different stents are discussed. Key words: Peripheral vascular diseases, Vascular stents, Peripheral angioplasty DOI: http://dx.doi.org/10.3329/cardio.v1i1.8215 Cardiovasc. j. 2008; 1(1) : 81-83

Peripheral Vascular Changes after Treatment of Severe Hypertension

1982 ◽  
Vol 63 (s8) ◽  
pp. 77s-79s ◽  
Author(s):  
T. Gudbrandsson ◽  
L. Hansson ◽  
H. Herlitz ◽  
R. Sivertsson
Keyword(s):  
Structural Changes ◽  
Matched Control ◽  
Malignant Hypertension ◽  
Control Group ◽  
Vascular Changes ◽  
Peripheral Vascular ◽  
Maximal Dilatation ◽  
Resistance Vessels ◽  
Vascular Beds

1. Blood flow resistance was studied in two peripheral vascular beds in 15 patients with previous malignant hypertension and in a matched group of patients with treated ‘benign’ hypertension and in matched control subjects. Studies were made during rest and after the induction of maximal vasodilatation. 2. In the hand (representing mainly a skin vessel bed), both hypertensive groups had significantly higher resistance at maximal dilatation than the normotensive group (2.5 and 2.5 units respectively as compared with 1.9 units, P < 0.01). 3. In the calf muscle vascular bed the patients with previous malignant hypertension had the most severe changes. Resistance at maximal dilatation was 2.4 units as compared with 1.9 units in the group with ‘benign’ hypertension (P < 0.05) and 1.6 units in the control group (P < 0.001 and P < 0.05 respectively). 4. These findings indicate structural changes in the resistance vessels of both hypertensive groups, which means that, in spite of substantial long-term lowering of blood pressure, arteriolar vascular changes remain. Accordingly, these changes may not be entirely reversible. The degree of reversibility also appears to be different in the two vascular beds studied.

Structured surveillance of patients with peripheral arterial occlusive disease after peripheral vascular interventions

VASA ◽  
2009 ◽  
Vol 38 (4) ◽  
pp. 302-315 ◽  
Author(s):  
Weiss ◽  
Bergert
Keyword(s):  
Peripheral Arterial Disease ◽  
Integrated Approach ◽  
Arterial Disease ◽  
Evidence Based ◽  
Peripheral Vascular ◽  
Vascular Intervention ◽  
Peripheral Arterial

Longterm follow-up and surveillance after either an endovascular or an open surgical vascular intervention is an essential part of the angiologist’s or vascular surgeon’s care for patients with peripheral arterial disease. This includes diagnosis and treatment of cardiovascular risk factors, selection and monitoring of antiplatelet and/or anticoagulant therapy after revascularization, and surveillance of the results of the vascular intervention. This integrated approach to patients’ care will improve patients’ prognosis quoad vitam and quoad extremitatem and their quality of life. We summarize the rationale and evidence-based practical approaches and guidelines for structured long term surveillance of patients with peripheral arterial disease after a vascular intervention.

Formulating Industry-Academic Collaborations That Work: Best Practices to Ensure a Strong Relationship After the Agreements are Signed

2020 ◽  
Vol 21 (2) ◽  
pp. 169-177
Author(s):  
Michael B. Dilling ◽  
Anne C. DiSante ◽  
Ross Durland ◽  
Christine E. Flynn ◽  
Leonid Metelitsa ◽  
...  
Keyword(s):  
Decision Making ◽  
Best Practices ◽  
Product Development ◽  
Strong Relationship ◽  
Governance Structure ◽  
Collaborative Relationships ◽  
Skill Sets ◽  
Pragmatic Aspects

Collaborations between academia and industry are growing in scope, duration, and sophistication. The best collaborations recognize the unique strengths and skill sets of both parties and are structured to leverage what each party does best. In many cases, these collaborations develop into long-term relationships, and it is important to develop the systems and structures needed to support these relationships to ensure that they meet the needs of both sides. Successful collaborations require the formulation of a governance structure to facilitate communication, decision-making, assessment of progress, and the inevitable changes of direction that accompany product development. This panel explored the pragmatic aspects of successfully structuring collaborations and managing the relationships after the deal is done. Several dominant themes associated with successful collaborative relationships emerged from the discussion, and these will be explored in this article.

Characterization and clinical implications of peripheral arterial involvement in transthyretin cardiac amyloidosis cardiomyopathy

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
K Stamatelopoulos ◽  
D Delialis ◽  
D Bampatsias ◽  
M.E Tselegkidi ◽  
I Petropoulos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Significance ◽  
Vascular Involvement ◽  
Control Group ◽  
Peripheral Vascular ◽  
Cvd Risk Factors ◽  
Wave Reflections ◽  
Cvd Risk ◽  
Arterial Involvement ◽  
Peripheral Arterial

Abstract Background The sporadic form of transthyretin amyloidosis cardiomyopathy (ATTR-CM) is underdiagnosed but its prevalence is increasing due to the aging population. Given the poor prognosis of ATTR-CM understanding the underlying pathophysiologic mechanisms of the disease is imperative in order to improve strategies for early diagnosis and risk stratification and to develop new effective therapeutic options. ATTR-CM is associated with hypotension and there is preliminary experimental evidence of vascular involvement but its presence and clinical significance remains unknown. Purpose To characterize peripheral arterial involvement and explore its clinical role in ATTR-CM. Methods We consecutively recruited 28 previously untreated patients with newly diagnosed ATTR-CM and 34 elderly controls &gt;70 years old, without ATTR-CM or heart failure. In both groups, flow-mediated dilatation (FMD) and intima-media thickness (IMT) in the carotid arteries were measured by high-resolution ultrasonography as markers of peripheral vascular reactivity and of subclinical atherosclerosis, respectively. Carotid-femoral pulse wave velocity (PWV) was measured as a marker of arterial stiffness. Aortic blood pressure (BP) and augmentation index (AI) using applanation tonometry were measured as markers of arterial wave reflections, peripheral arterial resistance and central hemodynamics. Echocardiography was performed in all ATTR patients. All cardiovascular (CV) measurements were performed before administration of any ATTR-specific therapy. Results ATTR patients were older and had lower prevalence of hypertension and male gender (p&lt;0.05 for all) than the control group. Aortic and peripheral BP (p=0.016–0.088) and AI (p=0.003) were lower in ATTR patients. IMT in the common (cc) and internal carotid (ic) as well as in the carotid bulb (cb) were significantly higher in ATTR patients (p=0.001–0.042). After multivariable adjustment for traditional CV disease (CVD) risk factors, the ATTR group was independently associated with AI and IMT in cc, cb and ic (p&lt;0.05 for all). In a subgroup of subjects with similar age between groups (n=13 and n=33 and 74.5±2.9 vs. 75.6±3.6 years, for ATTR vs. controls, respectively) differences in AI and cbIMT remained significant. Interestingly, AI was strongly and inversely associated with interventricular wall thickness (IVwt) in ATTR patients (spearman rho=−0.651, p=0.001). After adjustment for traditional CVD risk factors this association remained significant. Conclusion ATTR-CM is associated with lower aortic wave reflections, which correlate with more advanced structural cardiac disease, as assessed by IVwt. Further, ATTR-CM patients present accelerated subclinical carotid atherosclerosis as compared to elderly control subjects. These findings suggest that in ATTR-CM there is disease-specific peripheral vascular involvement in parallel to cardiac involvement. The clinical significance of these findings merits further investigation. Funding Acknowledgement Type of funding source: None

scholarly journals Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3428
Author(s):  
Chaojie Zhu ◽  
Junkai Ma ◽  
Zhiheng Ji ◽  
Jie Shen ◽  
Qiwen Wang
Keyword(s):  
Cardiovascular Diseases ◽  
Cell Membrane ◽  
Preventive Therapy ◽  
Peripheral Vascular ◽  
Coating Technology ◽  
Immune Clearance ◽  
Coated Nanoparticles ◽  
Membrane Coating ◽  
Therapeutic Tools

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, causing approximately 17.9 million deaths annually, an estimated 31% of all deaths, according to the WHO. CVDs are essentially rooted in atherosclerosis and are clinically classified into coronary heart disease, stroke and peripheral vascular disorders. Current clinical interventions include early diagnosis, the insertion of stents, and long-term preventive therapy. However, clinical diagnostic and therapeutic tools are subject to a number of limitations including, but not limited to, potential toxicity induced by contrast agents and unexpected bleeding caused by anti-platelet drugs. Nanomedicine has achieved great advancements in biomedical area. Among them, cell membrane coated nanoparticles, denoted as CMCNPs, have acquired enormous expectations due to their biomimetic properties. Such membrane coating technology not only helps avoid immune clearance, but also endows nanoparticles with diverse cellular and functional mimicry. In this review, we will describe the superiorities of CMCNPs in treating cardiovascular diseases and their potentials in optimizing current clinical managements.

scholarly journals Patient characteristics predict patency of early-cannulation arteriovenous grafts

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
David B. Kingsmore ◽  
Karen S. Stevenson ◽  
S. Richarz ◽  
Andrej Isaak ◽  
Andrew Jackson ◽  
...  
Keyword(s):  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Vascular Access ◽  
Demographic Data ◽  
Univariate Analysis ◽  
Patient Characteristics ◽  
Peripheral Vascular ◽  
Arteriovenous Grafts ◽  
One Year

AbstractThere is a new emphasis on tailoring appropriate vascular access for hemodialysis to patients and their life-plans, but there is little known about the optimal use of newer devices such as early-cannulation arteriovenous grafts (ecAVG), with studies utilising them in a wide variety of situations. The aim of this study was to determine if the outcome of ecAVG can be predicted by patient characteristics known pre-operatively. This retrospective analysis of 278 consecutive ecAVG with minimum one-year follow-up correlated functional patency with demographic data, renal history, renal replacement and vascular access history. On univariate analysis, aetiology of renal disease, indication for an ecAVG, the number of previous tunnelled central venous catheters (TCVC) prior to insertion of an ecAVG, peripheral vascular disease, and BMI were significant associates with functional patency. On multivariate analysis the number of previous TCVC, the presence of peripheral vascular disease and indication were independently associated with outcome after allowing for age, sex and BMI. When selecting for vascular access, understanding the clinical circumstances such as indication and previous vascular access can identify patients with differing outcomes. Importantly, strategies that result in TCVC exposure have an independent and cumulative association with decreasing long-term patency for subsequent ecAVG. As such, TCVC exposure is best avoided or minimised particularly when ecAVG can be considered.

Endovascular Treatment of Iliac Occlusive Disease: Review and Update

Vascular ◽  
2007 ◽  
Vol 15 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Albeir Y. Mousa ◽  
Robert B. Beauford ◽  
Lucio Flores ◽  
Peter L. Faries ◽  
Prem Patel ◽  
...  
Keyword(s):  
Transluminal Angioplasty ◽  
Occlusive Disease ◽  
Success Rates ◽  
Endovascular Interventions ◽  
Late Failure ◽  
Therapeutic Measures ◽  
Comparison Of Techniques ◽  
Open Versus ◽  
Angioplasty And Stenting

Use of endovascular interventions for arterial occlusive lesions continues to increase. With the evolution of the technology supporting these therapeutic measures, the results of these interventions continue to improve. In general, a comparison of techniques for revascularization of iliac occlusive diseases shows similar initial technical success rates for open versus percutaneous transluminal angioplasty. Angioplasty is often associated with lower periprocedural morbidity and mortality rates. Conversely, surgery frequently provides greater long-term patency, although late failure of percutaneous therapies may occur but still can be treated successfully with reintervention. The perpetual buildup of experience with angioplasty and stenting will eventually characterize its role in the management of occlusive disease. This review outlines the current consensus and applicability of endovascular management of iliac occlusive diseases.

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