Atonic Seizures

1987 ◽  
Vol 9 (2) ◽  
pp. 43-49
Author(s):  
Michael S. Duchowny

Seizures consisting of rapidly arrested movement are relatively common and account for approximately 12% of all episodes. Atonic seizure is the preferred designation for this form of clinical presentation, although more descriptive terms such as "drop attack" and "epileptic fall" are also popular. Many clinicians still use the term "akinetic seizure," but this is inaccurate because attacks of behavioral immobility with preserved muscle tone and consciousness cannot be differentiated from absence seizures. Furthermore, it is unlikely that neurophysiologic mechanisms can arrest behavior without altering muscle tone or compromising consciousness. The accurate diagnosis and management of atonic seizures constitutes an important challenge for the practicing pediatrician. Whereas grand mal and petit mal seizures are well-known manifestations of epilepsy in childhood, seizures limited to the loss of muscle tone are more likely to go unrecognized. The large variety of nonepileptic conditions that mimic atonic seizures further adds to the difficulties of correct identification. DESCRIPTION Atonic seizures show considerable variation in presentation and severity. Typically, without warning, the voluntary muscles synchronously increase and then lose resting tone. No aura precedes these muscular changes. Both the myoclonic and atonic seizure components can cause the child to collapse limply to the ground. Massive myoclonus and loss of tone may even precipitate a violent fall from a sitting position (Fig 1), resulting in craniofacial injury, skull fracture, facial laceration, or dental trauma.

2021 ◽  
Vol 15 (8) ◽  
pp. 1-7
Author(s):  
Jonathan D. Pierce ◽  
Neal R. Shah ◽  
Ata A. Rahnemai-Azar ◽  
Amit Gupta

Tension gastrothorax is a rare, life-threatening clinical condition caused by intrathoracic herniation of the stomach through a diaphragmatic defect which becomes increasingly distended over time. If not recognized promptly, this can rapidly progress to respiratory distress, mediastinal shift, and hemodynamic compromise. Initial clinical presentation and imaging findings closely mirror those of tension pneumothorax, confounding diagnosis and potentially leading to unnecessary interventions with increased risk of morbidity and mortality. Here, we present a case of an elderly female who presented with a non-traumatic tension gastrothorax and a review of key imaging features and strategies to aid in recognition and accurate diagnosis of this emergent clinical entity.


Part of the Neurosurgery by Example series, this volume on pediatric neurosurgery presents exemplary cases in which renowned authors guide readers through the assessment and planning, decision making, surgical procedure, aftercare, and complication management of common and uncommon disorders. As pediatric neurosurgery approximates the anatomical and pathophysiological breadth of all specialty areas of adult neurosurgery, the cases provided are particularly relevant to and more frequently encountered in pediatric practice. They also reflect aspects of clinical presentation and management that are notably distinct in pediatric compared to adult neurosurgery. Each chapter also contains “pivot points” that illuminate changes required to manage patients in alternate or atypical situations, and “pearls” for accurate diagnosis, successful treatment, and effective complication management. Containing a focused review of medical evidence and expected outcomes, Pediatric Neurosurgery is appropriate for neurosurgeons who wish to learn more about this subspecialty and those preparing for the American Board of Neurological Surgery oral examination.


Author(s):  
Mark N. Rubin ◽  
Alejandro A. Rabinstein

The neurological manifestations of abnormal electrolyte concentrations and acid-base disturbances can be multiple and often nonspecific. They are typically determined by the acuity and severity of the derangement. Detailed history and physical examination may guide appropriate laboratory testing and lead to prompt and accurate diagnosis. Neurological symptoms and signs are typically reversible if the underlying systemic disorder is detected and treated early. However, severe long-term neurologic sequelae can occur if treatment is delayed. The focus of this chapter is to detail the scientific fundamentals, clinical presentation, laboratory testing, and management of the various electrolyte and acid-base disorders associated with neurologic impairment.


2006 ◽  
Vol 130 (11) ◽  
pp. 1693-1706 ◽  
Author(s):  
Rajmohan Murali ◽  
Kenneth Kneale ◽  
Nestor Lalak ◽  
Warick Delprado

Abstract Context.—Carcinoid tumors are exceedingly rare in the genitourinary tract and may occur in the kidney, urinary bladder, urethra, or prostate. Objective.—To review the clinical and pathologic features of carcinoid tumors occurring in the urinary tract and prostate. Data Sources.—We searched the English language literature using MEDLINE and Ovid. Conclusions.—Carcinoid tumors of the urinary tract and prostate share similar morphologic features with their counterparts in other organs. The differential diagnosis includes metastatic carcinoid tumor, paraganglioma, and nested variants of urothelial and prostatic carcinomas. Correlation of the clinical presentation and histopathologic features (including the immunohistochemical profile) will ensure accurate diagnosis of these rare tumors.


2020 ◽  
Vol 40 (01) ◽  
pp. 097-115
Author(s):  
Ram N. Narayan ◽  
Andrew McKeon ◽  
Terry D. Fife

AbstractAutoimmune disorders affecting the vestibular end organs, vestibular pathways, vestibular nuclei, and vestibulocerebellum are often underrecognized as a cause of chronic dizziness and ataxia. Autoantibodies specific for cell-surface, synaptic, and intracellular neural antigens serve as biomarkers of these disorders. This article describes the epidemiology, clinical presentation, diagnostic considerations, imaging findings, treatment, and prognosis of autoimmune disorders, in which the vestibulocerebellar syndrome is the main or presenting clinical presentation. Antibodies specific for intracellular antigenic targets described in the article are PCA-1 (Purkinje cell cytoplasmic antibody type 1, also known as anti-Yo), ANNA-1 (antinuclear neuronal antibody type 1, also known as anti-Hu), ANNA-2 (antinuclear neuronal antibody type 2, also known as anti-Ri), Ma1/2 (anti-Kelch-like 11/12 antibody), Kelch-like 11, amphiphysin, CV2 (collapsin response 2, also known as collapsin response mediator protein-5 [CRMP5]), VGCC (voltage-gated calcium channel), GAD65 (glutamic acid decarboxylase 65-kDa isoform), AP3B2 (adaptor protein 3B2, also known as anti-Nb), MAP1B (microtubule-associated protein 1B antibody, also known as anti-PCA-2), and neurochondrin antibodies. Antibodies targeting cell-surface or synaptic antigenic targets described in the article include DNER (delta/notchlike epidermal growth factor related receptor; antigen to anti-Tr), CASPR2 (contactin-associated proteinlike 2), septin-5, Homer-3, and mGluR1 (metabotropic glutamate receptor 1). The vestibulocerebellar presentation is largely indistinguishable among these conditions and is characterized by subacute onset of cerebellar symptoms over weeks to months. The diagnosis of autoimmune vestibulocerebellar syndromes is based on a combination of clinical and serological features, with a limited role for neuroimaging. Subtle eye movement abnormalities can be an early feature in many of these disorders, and therefore a meticulous vestibulo-ocular examination is essential for early and correct identification. Cancer occurrence and its type are variable and depend on the autoantibody detected and other cancer risk factors. Treatment comprises immunotherapy and cancer-directed therapy. Acute immunotherapies such as intravenous immunoglobulin, plasma exchange, and steroids are used in the initial phase, and the use of long-term immunosuppression such as rituximab may be necessary in relapsing cases. Outcomes are better if immunotherapy is started early. The neurologic prognosis depends on multiple factors.


Author(s):  
Khushbu Adhikari ◽  
Anita Shah

Localised gingival overgrowth is commonly encountered in our practice. They can be histologically different such as the peripheral giant cell granuloma, giant cell fibroma, pyogenic granuloma or fibroma. A diagnosis based only on the clinical feature is difficult to make because of their similarity in clinical presentation with other gingival overgrowths. Therefore, histopathological examination is mandatory for making an accurate diagnosis that will ultimately help us to treat the underlying disease. This is a case report of Peripheral cemento-ossifying fibroma, which is a slow progressing and asymptomatic gingival growth until it causes noticeable deformity.


Author(s):  
Ирина Владимировна Косолапова ◽  
Евгений Владимирович Дорохов ◽  
Михаил Эдуардович Коваленко

Цель работы: Разработка прогностических моделей для оценки зависимости коэффициента асимметрии тонуса собственно жевательных мышц от функциональных параметров жевательных мышц и иммуноферментного состава ротовой жидкости на различных этапах ортодонтической коррекции. Материал и методы исследования: В исследовании приняли участие 82 пациента Детской клинической стоматологической поликлиники №2 г. Воронежа в возрасте от 6 до 12 лет с дистальной окклюзией зубных рядов, которым было рекомендовано лечение пластиночным аппаратом в модификации Шварца. Проводилась оценка функциональных параметров жевательных мышц: средней амплитуды биоэлектрической активности височных и подъязычных мышц, тонуса покоя и коэффициента асимметрии собственно жевательных мышц; количественное определение общих иммуноглобулинов G, А, M и секреторного иммуноглобулина A ротовой жидкости до начала лечения, через 3 и через 6 месяцев. Статистический анализ осуществлялся с использованием программ IBM SPSS Statistics 20, StatTech v. 1.2.0. Прогностическая модель, характеризующая зависимость количественной переменной от факторов, разрабатывалась с помощью метода множественной линейной регрессии. Результаты: Разработаны 2 прогностические модели. Полученные данные связаны с перестройкой функциональных параметров жевательной мускулатуры в результате ортодонтической коррекции. Вывод: Разработаны 2 прогностические модели для оценки зависимости коэффициента асимметрии тонуса собственно жевательных мышц от функциональных параметров жевательных мышц и иммуноферментного состава ротовой жидкости через 3 и 6 месяцев ортодонтической коррекции, которые позволят врачу грамотно выстроить план лечения, спрогнозировать его срок, повысить качество и эффективность диагностики The purpose of the work: Development of prognostic models for assessing the dependence of the asymmetry coefficient of the tone of the chewing muscles proper on the functional parameters of the chewing muscles and the immunoenzyme composition of the oral fluid at various stages of orthodontic correction. Material and methods of research: The study was attended by 82 patients of the Children's Clinical Dental Clinic No. 2 of Voronezh, aged 6 to 12 years, with distal occlusion of the dentition, who were recommended for treatment with a plate machine in the Schwartz modification. The functional parameters of chewing muscles were evaluated: the average amplitude of the bioelectric activity of temporal and sublingual muscles, the resting tone and the asymmetry coefficient of the chewing muscles themselves; quantification of total immunoglobulins G, A, M and oral fluid secretory immunoglobulin A before treatment, at 3 and 6 months. Statistical analysis was carried out using IBM SPSS Statistics 20, StatTech v. 1.2.0 (developer - Stattech LLC, Russia). A predictive model characterizing the dependence of a quantitative variable on factors was developed using the multiple linear regression method. Results: 2 prognostic models developed. The obtained data are related to reconfiguration of functional parameters of chewing muscles as a result of orthodontic correction. Conclusion: 2 prognostic models have been developed to assess the dependence of the asymmetry coefficient of the tone of the chewing muscles proper on the functional parameters of the chewing muscles and the immunoenzyme composition of the oral fluid after 3 and 6 months of orthodontic correction, which will allow the doctor to competently build a treatment plan, predict its duration, increase the quality and effectiveness of diagnosis


2018 ◽  
Vol 39 (03) ◽  
pp. 343-350 ◽  
Author(s):  
Steven Cowman ◽  
Michael Loebinger

AbstractThe diagnosis of pulmonary nontuberculous mycobacteria (NTM) disease may be challenging, as their presence alone does not necessarily indicate disease and diagnosis requires the integration of clinical, radiological, and microbiological findings. The first step is to suspect NTM disease; however, clinical manifestations of NTM are nonspecific and it may not be possible to separate them from those caused by underlying respiratory disease. The radiological appearance generally falls into two patterns, fibrocavitary disease and nodular-bronchiectatic disease; consolidation, infiltrates, and solitary nodules are also described. The isolation of NTM from clinical samples is fundamental to the diagnosis and they may be cultured from sputum, bronchoalveolar lavage fluid, or tissue specimens. If sputum is used, more than one isolate is required for diagnosis due to the propensity of NTM to contaminate clinical samples. The correct identification of NTM is vital, as their clinical relevance varies widely between species, and treatment is dictated by the identity of the isolated organism. This review covers the clinical presentation of NTM disease, the interpretation of radiological findings, and issues surrounding the isolation and identification of mycobacteria.


Cephalalgia ◽  
2020 ◽  
pp. 033310242097435
Author(s):  
Antonio Palmieri ◽  
Luca Valentinis ◽  
Giorgio Zanchin

Headache is one of the leading symptoms often associated with brain tumours. Secondary headaches attributed to intracranial neoplasias have been included in subchapter 7.4 of the third edition of the International Classification of Headache Disorders (ICHD-3). According to ICHD-3, the headache may be attributed to a brain tumour if it has developed in close temporal relation with the development of the neoplasia, has significantly worsened in parallel with the worsening of the tumour, and/or has significantly improved following the successful treatment of the neoplasia. Brain tumour headache was traditionally thought to display some specific clinical characteristics, including worsening in the morning and/or when lying down, being aggravated by Valsalva-like manoeuvres and accompanied by nausea and/or vomiting; however, the studies performed after the advent of modern neurodiagnostic techniques have pointed out that the “classic” brain tumour headache is uncommon, particularly at the time of clinical presentation. Therefore, it becomes critical to seek some specific factors associated with the presence of an intracranial mass (the so-called “red flags”) that can guide the physician to establish an accurate diagnosis.


2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Aleksei Rakitin ◽  
Riina Vibo ◽  
Vaiko Veikat ◽  
Anne Õunapuu ◽  
Aive Liigant ◽  
...  

Creutzfeldt-Jakob disease is a rare, rapidly progressive spongiform encephalopathy in humans. EEG plays an important role in diagnosing this disease. In some patients, epileptic activity and encephalopathy from various aetiologies may share morphological features on EEG. This similarity could create difficulties in EEG interpretation, especially if the patient presents with disturbed consciousness. In this case report, a 74-year-old female with Creutzfeldt-Jakob disease presented initially with rapidly progressive impairment of consciousness and focal epileptiform activity on EEG. An EEG performed 25 days later showed periodic sharp-wave complexes with triphasic morphology at a rate of 0.5 Hz, compatible with a diagnosis of Creutzfeldt-Jakob disease. Based on these results, we recommend that a diagnosis of Creutzfeldt-Jakob disease be considered in patients presenting with a rapid deterioration of consciousness and a clinical presentation of nonconvulsive status epilepticus. Monitoring these patients with serial EEGs could be useful to establish an accurate diagnosis.


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