scholarly journals Creutzfeldt-Jakob Disease Presenting as Nonconvulsive Status Epilepticus

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Aleksei Rakitin ◽  
Riina Vibo ◽  
Vaiko Veikat ◽  
Anne Õunapuu ◽  
Aive Liigant ◽  
...  
Keyword(s):  
Case Report ◽  
Status Epilepticus ◽  
Clinical Presentation ◽  
Epileptiform Activity ◽  
Epileptic Activity ◽  
Accurate Diagnosis ◽  
Morphological Features ◽  
Nonconvulsive Status Epilepticus ◽  
Spongiform Encephalopathy ◽  
Jakob Disease

Creutzfeldt-Jakob disease is a rare, rapidly progressive spongiform encephalopathy in humans. EEG plays an important role in diagnosing this disease. In some patients, epileptic activity and encephalopathy from various aetiologies may share morphological features on EEG. This similarity could create difficulties in EEG interpretation, especially if the patient presents with disturbed consciousness. In this case report, a 74-year-old female with Creutzfeldt-Jakob disease presented initially with rapidly progressive impairment of consciousness and focal epileptiform activity on EEG. An EEG performed 25 days later showed periodic sharp-wave complexes with triphasic morphology at a rate of 0.5 Hz, compatible with a diagnosis of Creutzfeldt-Jakob disease. Based on these results, we recommend that a diagnosis of Creutzfeldt-Jakob disease be considered in patients presenting with a rapid deterioration of consciousness and a clinical presentation of nonconvulsive status epilepticus. Monitoring these patients with serial EEGs could be useful to establish an accurate diagnosis.

scholarly journals Creutzfeldt-Jakob Disease Presenting as Expressive Aphasia and Nonconvulsive Status Epilepticus

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Hafiz B. Mahboob ◽  
Kazi H. Kaokaf ◽  
Jeremy M. Gonda
Keyword(s):  
Status Epilepticus ◽  
Clinical Presentation ◽  
Prion Diseases ◽  
Epileptiform Activity ◽  
Rare Condition ◽  
Nonconvulsive Status Epilepticus ◽  
Mri Findings ◽  
Progressive Dementia ◽  
Csf Analysis ◽  
Jakob Disease

Creutzfeldt-Jakob disease (CJD), the most common form of human prion diseases, is a fatal condition with a mortality rate reaching 85% within one year of clinical presentation. CJD is characterized by rapidly progressive neurological deterioration in combination with typical electroencephalography (EEG) and magnetic resonance imaging (MRI) findings and positive cerebrospinal spinal fluid (CSF) analysis for 14-3-3 proteins. Unfortunately, CJD can have atypical clinical and radiological presentation in approximately 10% of cases, thus making the diagnosis often challenging. We report a rare clinical presentation of sporadic CJD (sCJD) with combination of both expressive aphasia and nonconvulsive status epilepticus. This patient presented with slurred speech, confusion, myoclonus, headaches, and vertigo and succumbed to his disease within ten weeks of initial onset of his symptoms. He had a normal initial diagnostic workup, but subsequent workup initiated due to persistent clinical deterioration revealed CJD with typical MRI, EEG, and CSF findings. Other causes of rapidly progressive dementia and encephalopathy were ruled out. Though a rare condition, we recommend consideration of CJD on patients with expressive aphasia, progressive unexplained neurocognitive decline, and refractory epileptiform activity seen on EEG. Frequent reimaging (MRI, video EEGs) and CSF examination might help diagnose this fatal condition earlier.

scholarly journals Catatonia, beyond a psychiatric syndrome

2017 ◽  
Vol 11 (2) ◽  
pp. 209-212
Author(s):  
Nathália Stela Visoná de Figueiredo ◽  
Débora Bartzen Moraes Angst ◽  
Antônio de Matos Lima Neto ◽  
Michel Ferreira Machado ◽  
Maria Sheila Guimarães Rocha ◽  
...  
Keyword(s):  
Case Report ◽  
Status Epilepticus ◽  
Clinical Manifestation ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Nonconvulsive Status Epilepticus ◽  
Diagnostic Investigation ◽  
Venous Sinus Thrombosis ◽  
Psychiatric Syndrome

ABSTRACT Although catatonia is a well-known psychiatric syndrome, there are many possible systemic and neurological etiologies. The aim of this case report was to present a case of a patient with cerebral venous sinus thrombosis and infarction in which catatonia was the clinical manifestation of a possible nonconvulsive status epilepticus. To our knowledge, only one such case has been reported in the literature, which had a simplified diagnostic investigation. It is important to correctly recognize the organic cause underlying catatonia in order to treat the patient as soon as possible thereby improving outcome. Therefore, physicians need to update their knowledge on catatonia, recognizing that it can be part of a psychiatric or neurologic condition.

Sporadic Creutzfeldt-Jakob disease mimicking nonconvulsive status epilepticus

Neurology ◽  
2011 ◽  
Vol 76 (12) ◽  
pp. 1111-1112 ◽  
Author(s):  
J. L. Fernandez-Torre ◽  
W. D. Freeman ◽  
E. Shuster ◽  
P. Brazis ◽  
D. Dickson ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Nonconvulsive Status Epilepticus ◽  
Jakob Disease

Creutzfeldt-Jakob Disease Presenting as Refractory Nonconvulsive Status Epilepticus

2004 ◽  
Vol 19 (6) ◽  
pp. 345-348 ◽  
Author(s):  
Janet M. Shapiro ◽  
Adil Shujaat ◽  
Jill Wang ◽  
Xiaowei Chen
Keyword(s):  
Status Epilepticus ◽  
Nonconvulsive Status Epilepticus ◽  
Jakob Disease

Pediatric Metronidazole-Induced Encephalopathy: A Case Report and Review of the Literature

2020 ◽  
Author(s):  
Alberto M. Cappellari ◽  
Donata Rossetti ◽  
Sabrina Avignone ◽  
Elisa Scola ◽  
Antonio Di Cesare
Keyword(s):  
Case Report ◽  
Status Epilepticus ◽  
Antimicrobial Drug ◽  
Adult Patients ◽  
Nonconvulsive Status Epilepticus ◽  
Toxic Encephalopathy ◽  
Review Of The Literature ◽  
The Common

AbstractMetronidazole-induced encephalopathy is a rare toxic encephalopathy secondary to the common use to this antimicrobial drug. It has been reported mainly in adult patients but only rarely in children. Owing to possible devastating complication of this disease, clinicians should have a higher index of suspicion for encephalopathic patients on metronidazole therapy. Here, we report a 5-month-old infant with metronidazole-induced encephalopathy presenting with nonconvulsive status epilepticus. A review of the literature in pediatric, as well as adult metronidazole-induced encephalopathy, is also provided.

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