Quinacrine Hydrochloride-Induced Yellow Discoloration of the Skin in Children

PEDIATRICS ◽  
1982 ◽  
Vol 69 (2) ◽  
pp. 232-233
Author(s):  
Ronald J. Sokol ◽  
Philip K. Lichtenstein ◽  
Michael K. Farrell
Keyword(s):  
Case Report ◽  
Drug Administration ◽  
Side Effect ◽  
Common Side Effect ◽  
Clinical Method ◽  
The Past ◽  
Drug Of Choice ◽  
Bowel Movements ◽  
Alternative Drug ◽  
History Of

The drug of choice for treatment of giardiasis in children has changed over the past several years. Metronidazole (Flagyl) has been found to be carcinogenic in mice and mutagenic in bacteria,1 and is, therefore, no longer approved by the Food and Drug Administration for the treatment of giardiasis. Thus, quinacrine hydrochloride (Atabrine) is the recommended alternative drug for the treatment of giardiasis in children. The purpose of this report is to remind physicians of a common side effect of quinacrine hydrochloride and to call attention to a simple clinical method for its confirmation. CASE REPORT S.W., a 3-year-old white boy, had a three-week history of three to six loose, watery bowel movements per day.

scholarly journals Rituximab induced cytokine release syndrome in an MS patient: a case report

2021 ◽  
Author(s):  
Masoud Etemadifar ◽  
Mehri Salari ◽  
Mahdieh Saeri ◽  
Amirhossein Akhavan Sigari ◽  
Sara Ebrahimi
Keyword(s):  
Multiple Sclerosis ◽  
Case Report ◽  
Side Effect ◽  
Signs And Symptoms ◽  
Common Side Effect ◽  
Cytokine Release ◽  
Cytokine Release Syndrome ◽  
Relapsing Remitting ◽  
History Of ◽  
Relapsing Remitting Multiple Sclerosis

Rituximab use in multiple sclerosis has been promising. Cytokine release syndrome (CRS) is a common side effect of rituximab in patients with lymphoma. We report a case of a 44-year-old man with a history of relapsing-remitting multiple sclerosis, who presented with signs and symptoms consistent with CRS after rituximab initiation.

It is not always COVID-19: Case report about an undiagnosed HIV man with dyspnea

2021 ◽  
Vol 19 ◽  
Author(s):  
Michela Pontolillo ◽  
Katia Falasca ◽  
Jacopo Vecchiet ◽  
Claudio Ucciferri
Keyword(s):  
Case Report ◽  
Diagnostic Assays ◽  
Radiological Features ◽  
The Past ◽  
Undiagnosed Hiv ◽  
History Of ◽  
Clinical Conditions ◽  
Diagnostic Thinking ◽  
Diagnostic Delays ◽  
Analyze Data

Background: The current COVID-19 pandemic has attracted great attention from the medical world. In the past year, there have been reports of missed or delayed treatments for conditions that mimic COVID-19. The main symptoms caused by SARS-CoV-2, such as fever and cough, belong to different clinical conditions. It is of the utmost importance that the diagnostic thinking used to analyze data and information to reach a COVID-19 diagnosis does not overlook the plethora of different diagnoses related to these symptoms. Case report: The aim of this work is to present the clinical case of a patient having unrecognized HIV infection with a 4-week history of fever, cough, and hypoxia. When tests were allowed to highlight HIV-related immunodeficiency status, a CMV assay was performed in order to evaluate opportunistic pneumonia. Through this, diagnosis of HIV combined with CMV pneumonia was made, thus excluding COVID-19 respiratory insufficiency. Conclusion: The diagnosis of the two conditions in the COVID-19 era is challenging due to overlapping clinical and radiological features and limitations of current diagnostic assays. This causes clinical implications due to diagnostic delays.

scholarly journals Treatment of Fraley’s syndrome by upper-pole nephrectomy

2007 ◽  
Vol 125 (6) ◽  
pp. 354-355
Author(s):  
Thaís Bandeira Cerqueira ◽  
Natalia Bacellar Costa Lima ◽  
Romeu Magno Baptista Neto ◽  
José Cohim Moreira Filho ◽  
Luiz Eduardo Café
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Emergency Care ◽  
Lumbar Pain ◽  
Vascular Compression ◽  
The Past ◽  
Renal Arteriography ◽  
History Of ◽  
The Right

CONTEXT: Fraley’s syndrome is characterized by vascular compression on the superior infundibulum with secondary dilatation of the upper pole calyx, mostly located on the right side. CASE REPORT: We present the case of a 22-year-old woman with vascular compression of the upper-pole infundibulocalyceal system (Fraley’s syndrome). The patient had a history of frequent hospitalizations for emergency care due to lumbar pain over the past twelve months. The diagnosis was obtained following renal arteriography. Since the surgical treatment by means of upper-pole nephrectomy, the patient has not had any further symptoms.

Nasal vestibulitis: An MNCCTN natural history trial—Nasal vestibulitis symptoms associated with paclitaxel, docetaxel, and other chemotherapy agents.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e24086-e24086
Author(s):  
Elizabeth Jane Cathcart-Rake ◽  
David Zahrieh ◽  
Deanne s. Smith ◽  
Susan Young ◽  
Eric G. Wolfe ◽  
...  
Keyword(s):  
Natural History ◽  
Side Effect ◽  
Nasal Symptom ◽  
Smoking History ◽  
Common Side Effect ◽  
Point Scale ◽  
Nasal Symptoms ◽  
History Of ◽  
New Treatment ◽  
Taxane Chemotherapy

e24086 Background: Nasal vestibulitis has been infrequently described as a side effect of cancer-directed therapy; however, a preliminary study reported that 71% of patients undergoing taxane chemotherapy experienced nasal vestibulitis symptoms. This natural history trial describes the incidence, characteristics, and severity of nasal vestibulitis symptoms among patients undergoing paclitaxel, docetaxel, and non-taxane chemotherapy. Methods: Eligible participants who reported baseline (prior to starting chemotherapy) nasal symptoms ≤ 2 on a 10-point scale were enrolled in this trial upon initiation of a new treatment regimen, involving paclitaxel or docetaxel, or non-taxane chemotherapy. Participants completed nasal symptom logs each time they received a dose of therapy until either the regimen was stopped or four months had passed. The proportion of patients reporting new nasal symptoms was estimated within each cohort with the 95% exact confidence interval (CI). A cumulative incidence model was utilized to quantify the incidence of treatment-emergent nasal symptoms within each cohort, while controlling for age, sex, smoking history, and history of asthma or allergies. Results: Thirty-five participants received paclitaxel, 21 received docetaxel, and 25 received other types of chemotherapy. 86.4% of participants were female, mean age was 60.2 ± 11.2 years; 93.8% of participants completed 2 or more surveys. A higher percentage of participants in the paclitaxel cohort experienced new nasal vestibulitis symptoms than participants in the other two cohorts. The percentage (95% CI) of participants with nasal symptoms, for patients receiving paclitaxel, docetaxel, and non-taxane chemotherapy were 74.3% (56.7%, 87.5%), 47.6% (25.7%, 70.2%), and 44.0% (24.4%, 65.1%), respectively. Epistaxis was reported by 60% of participants in the paclitaxel cohort. Paclitaxel-receiving participants also reported nasal dryness (48.6%), scabbing (40.0%), and pain (20.0%). Nearly half of participants reported moderate symptoms (4-7 out of a 10-point scale), with 8.6% reporting symptoms as severe (8-10 on a 10-point scale). Conclusions: Nasal vestibulitis is a common side effect of chemotherapy, especially paclitaxel chemotherapy.

scholarly journals Case Report: Migrainous Infarct without Aura

2017 ◽  
Vol 9 (3) ◽  
pp. 241-251
Author(s):  
Kamesh Gupta ◽  
Anurag  Rohatgi ◽  
Shivani Handa
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Case Report ◽  
Rare Case ◽  
Case Presentation ◽  
The Past ◽  
Need To Evaluate ◽  
History Of ◽  
Complicated Migraine ◽  
Full Investigation

Background: Stroke in a migraine with aura has been documented in several cases, even deserving the merit of a classification as complicated migraine. Herein, we present a rare case of migrainous infarct without aura. The diagnosis was challenging due to lack of risk factors. The patient was unique in not having any other comorbidities. Case Presentation: The case is of a 21-year-old female presenting with right-sided hemiplegia and facial drooping. She had had an index presentation of throbbing headaches for the past 2 years, typical of a migraine but not preceded by any aura symptoms. However, in the current episode, the pain became excessively severe and accompanied by right-sided hemiplegia and facial drooping. A full investigation workup using MRI revealed evidence of infarct in the left temporoparietal and basal ganglion region. Conclusion: Our case highlights the need to evaluate silent ischemic stroke in case of prolonged headache with a history of migraine as well as the need for precaution to avoid the use of triptans or opioids in such a case. It also highlights the conditions that need to be excluded before labeling it as a migrainous infarct.

scholarly journals Untreated Active Tuberculosis in Pregnancy with Intraocular Dissemination: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Shadi Rezai ◽  
Stephen LoBue ◽  
Daniel Adams ◽  
Yewande Oladipo ◽  
Ramses Posso ◽  
...  
Keyword(s):  
Case Report ◽  
Developed Countries ◽  
Physiological Changes ◽  
Review Of The Literature ◽  
X Ray ◽  
Delay In Diagnosis ◽  
The Past ◽  
History Of ◽  
Chest X Ray ◽  
Patient Refusal

Background.Tuberculosis (TB) is a disease that affects hundreds of millions of people across the world. However, the incidence in developed countries has decreased over the past decades causing physicians to become unfamiliar with its unspecific symptoms. Pregnant individuals are especially difficult because many symptoms of active TB can mimic normal physiological changes of pregnancy. We present a case report of a 26-year-old multiparous woman, G4P3003, at 38-week gestation with a history of positive PPD who emigrated from Ghana 6 years ago. She came to the hospital with an initial complaint of suprapubic pain, pressure, and possible leakage of amniotic fluid for the past week. Patient also complained of a productive cough for the past 3 to 4 months with a decrease in vision occurring with the start of pregnancy. Visual acuity was worse than 20/200 in both eyes. Definitive diagnosis of active TB was delayed due to patient refusal of chest X-ray. Fortunately, delay in diagnosis was minimized since patient delivered within 24 hours of admission. Active TB was confirmed with intraocular dissemination. Patient had optic atrophy OS (left eye) and papillitis, choroiditis, and uveitis OD (right eye) due to TB infiltration. Fetus was asymptomatic and anti-TB therapy was started for both patients.

scholarly journals A Problem Lurking Just Below the Surface

2015 ◽  
Vol 2 (3) ◽  
pp. 501-525
Author(s):  
Terrell Fenner
Keyword(s):  
United States ◽  
Natural Resources ◽  
Side Effect ◽  
Oil And Gas ◽  
The United States ◽  
The State ◽  
Oil And Gas Development ◽  
The Past ◽  
History Of ◽  
Effective Remedy

A long history of oil and gas development in Texas has made the state the number one energy producer in the United States, and the bulk of that energy is produced from fuels acquired by drilling into the vast natural resources that sit below the state. As a side effect of this long history, it is common for the surface and mineral estates in Texas to be severed, and many severances happened several generations ago. This history has spread mineral interests between dozens of owners in some cases, many who are unknown and cannot be found. Absentee ownership has diluted the value of these fractionalized interests and has made use by their non-absentee counterparts more difficult. Existing laws that have been used in the past to clear absentee owners from title have not been effective in the context of a severed mineral estate, as those laws evolved primarily to address surface interests, or to accomplish other purposes with only incidental effect on land titles. This Comment discusses the inadequacy of the current methods used in Texas to remove absentee owners from mineral titles and illustrates the need for a more effective remedy. It then offers a dormant mineral act that suits the unique cultural and economic needs of Texas and addresses the growing fractionalization of Texas’s mineral estates.

scholarly journals Vulvar Hemangioma: Case Report

2018 ◽  
Vol 40 (06) ◽  
pp. 369-371
Author(s):  
Janine Silva ◽  
Emily Calife ◽  
João Cabral ◽  
Hildemárzio Andrade ◽  
Ana Gonçalves
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Female Patient ◽  
Surgical Approach ◽  
Benign Neoplasm ◽  
Surgical Excision ◽  
Genital Ulcer ◽  
Emotional Disability ◽  
The Past ◽  
History Of

AbstractHemangioma is a benign neoplasm that may affect the vulva, and it can cause functional or emotional disability. This article reports the case of a 52-year-old female patient with a history of a genital ulcer for the past 3 years and who had undergone various treatments with creams and ointments. The patient was biopsied and diagnosed with vulvar hemangioma and was subsequently submitted to surgical excision of the lesion. We emphasize the importance of following the steps of the differential diagnosis and proceeding with a surgical approach only if necessary.

scholarly journals The Full Spectrum of Infective Endocarditis: Case Report and Review

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Aniket S. Rali ◽  
Mejalli Al-Kofahi ◽  
Nilay Patel ◽  
Benjamin Wiele ◽  
Zubair Shah ◽  
...  
Keyword(s):  
Case Report ◽  
Infective Endocarditis ◽  
Clinical Symptoms ◽  
Intravenous Drug Use ◽  
Full Spectrum ◽  
The Past ◽  
History Of ◽  
Adequate Evaluation ◽  
Variable Presentation

Over the past five decades, the incidence of intravenous drug use- (IVDU-) associated infective endocarditis (IE) has been on the rise in North America. Classically, IVDU has been thought to affect right-sided valves. However, in recent times a more variable presentation of IVDU-associated IE has been reported. Here, we report a case of a patient with a known history of IVDU who presented with clinical symptoms concerning for right- as well as left-sided endocarditis. In addition, we also discuss what should be considered adequate evaluation for patients with suspected endocarditis, and more specifically, what should be the role of transesophageal echocardiography in patients with IE noted on transthoracic echocardiography.

scholarly journals No Bull: A Case of Alpha-Gal Syndrome Associated With Buffalo Meat Sensitivity

2019 ◽  
Vol 10 ◽  
pp. 215265671989336
Author(s):  
Marija Rowane ◽  
Reimus Valencia ◽  
Benjamin Stewart-Bates ◽  
Jason Casselman ◽  
Robert Hostoffer
Keyword(s):  
Case Report ◽  
Immunoglobulin E ◽  
Case Reports ◽  
The United States ◽  
Tick Saliva ◽  
Buffalo Meat ◽  
The Past ◽  
First Case ◽  
Delayed Anaphylaxis ◽  
History Of

Introduction Alpha (⍺)-gal syndrome (AGS) is an immunoglobulin E (IgE) antibody response against the glycoprotein carbohydrate galactose-⍺-1,3-galactose-β-1-(3)4-N-acetylglucosamine-R (Gal⍺-1,3Galβ1-(3)4GlcNAc-R or ⍺-gal) that is present in Ixodida (tick) saliva and noncatarrhine mammals as well as cetuximab, antivenom, and the zoster vaccine. The most frequently observed anaphylactic reactions in AGS are observed after beef, pork, lamb, and deer meat consumption. We present the first case of anaphylaxis to buffalo meat. Case Report A 55-year-old man presented with a history of recurrent urticaria that only developed approximately 7 hours after buffalo consumption. The patient denied history of Ixodidae bites but admitted to frequent hiking outdoors. Anti-⍺-1,3-gal IgE was positive (30.80 kU/L). The patient was advised to strictly avoid red meat. Discussion The prevalence of AGS has been increased in all continents in the past decade, and several Ixodidae species have been associated with this hypersensitivity. The list of IgE-mediated reactions to various types of meat has expanded to kangaroo, whale, seal, and crocodile, although these have not been associated with AGS. van Nunen only cautioned against consumption of exotic meats, such as buffalo, but no published case report describes AGS associated with anaphylaxis to this type of meat. Conclusion AGS is a mammalian meat allergy that has been increasingly prevalent worldwide, especially in Ixodidae endemic regions of Australia and the United States. Multiple AGS case reports published in the past decade demonstrate rapidly increasing understanding of underlying mechanisms provoking ongoing sensitization to help devise management strategies and dietary information. We offer the first case report of delayed anaphylaxis to buffalo meat.

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