ISLET CELL ADENOMA IN THE NEWBORN: REPORT OF TWO PATIENTS

PEDIATRICS ◽  
1971 ◽  
Vol 48 (2) ◽  
pp. 232-236
Author(s):  
M. J. Robinson ◽  
A. Murray Clarke ◽  
Hugo Gold ◽  
J. F. Connelly
Keyword(s):  
Islet Cell ◽  
Islet Cell Tumor ◽  
Severe Hypoglycemia ◽  
Cell Tumor ◽  
Normal Birth Weight ◽  
Neonatal Hypoglycemia ◽  
Cell Adenoma ◽  
Subtotal Pancreatectomy ◽  
Normal Birth ◽  
Obscure Origin

Islet cell adenoma is a rare cause of severe neonatal hypoglycemia. Two cases are reported and difficulties in diagnosis are outlined. In one infant, cure followed subtotal pancreatectomy at the age of 19 days. It is suggested that severe hypoglycemia of obscure origin persisting beyond the age of 2 weeks in a newborn infant of normal birth weight and not responding to standard medical measures, justifies exploration of the pancreas. Even if an islet-cell tumor is not identified, subtotal pancreatectomy is indicated.

scholarly journals An Adrenocortical Carcinoma Associated with Non-Islet Cell Tumor Hypoglycemia and Aberrant ACTH Production

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
M. D. S. A. Dilrukshi ◽  
A. W. Wickramarachchi ◽  
D. D. K. Abeyaratne ◽  
Brian Shine ◽  
Bahram Jafar-Mohammadi ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cushing’S Syndrome ◽  
Adrenocortical Carcinoma ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Severe Hypoglycemia ◽  
Cushing's Syndrome ◽  
Cell Tumor ◽  
Adrenocortical Carcinomas ◽  
Tumor Hypoglycemia

Introduction. Adrenocortical carcinomas (ACCs) are infrequently reported to present with severe hypoglycemia syndrome resulting from the secretion of insulin-like growth factor II (IGF-II) by tumor cells. Adrenocorticotropic hormone- (ACTH) independent hypercortisolism is the norm of hormonally active ACCs, but aberrant ACTH production by tumor cells can theoretically cause ACTH-dependent hypercortisolism. The purpose of this report was to present a case of an ACC manifested with the co-occurrence of two extremely rare presentations. Case Description. We present a rare case of a 43-year-old male patient admitted with recurrent episodes of severe non-ketotic and non-insulin-mediated hypoglycemia due to IGF-II mediated disease and ACTH-dependent Cushing’s syndrome. He was diagnosed with a diffusely disseminated adrenocortical carcinoma with immunohistochemistry of tumor cells showing focal ACTH immunostain positivity. Conclusion. Non-islet cell tumor hypoglycemia and ACTH-dependent Cushing’s syndrome are extremely rare presentations of an ACC, and co-occurrence of these entities in a single patient is never reported in the literature.

Severe hypoglycemia with “Big”-IGF-2 oversecretion by a giant phyllode tumor of the breast: A rare case of non-islet cell tumor-induced hypoglycemia (NICTH)

2012 ◽  
Vol 73 (5) ◽  
pp. 488-491 ◽  
Author(s):  
Emeline Renard ◽  
Christelle Langbour-Remy ◽  
Marc Klein ◽  
Yves Le Bouc ◽  
Georges Weryha ◽  
...  
Keyword(s):  
Islet Cell ◽  
Rare Case ◽  
Islet Cell Tumor ◽  
Severe Hypoglycemia ◽  
Cell Tumor ◽  
Phyllode Tumor

Letters to the Editor

PEDIATRICS ◽  
1968 ◽  
Vol 42 (2) ◽  
pp. 372-372
Author(s):  
Doris H. Milman
Keyword(s):  
Newborn Infant ◽  
Islet Cell ◽  
Recent Literature ◽  
Neonatal Period ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Letters To The Editor ◽  
Cell Adenoma

In the April issue of Pediatrics (41:789, 1968) Drs. Garces, Drash, and Kenny report a case of islet cell adenoma and hypoglycemia in a newborn infant. They state, "only two well documented cases with onset of symptoms in the neonatal period have been reported in the literature." They apparently refer only to recent literature, since they cite no references prior to 1960. In fact, Dr. Harry Sherman1 reported a case of islet cell tumor in the newborn in 1947.

Neonatal Islet Cell Adenoma: A Distinct Type of Islet Cell Tumor?

Diabetes Care ◽  
1982 ◽  
Vol 5 (2) ◽  
pp. 122-125 ◽  
Author(s):  
C. Bordi ◽  
M. Ravazzola ◽  
A. POllak ◽  
G. Lubec ◽  
L. Orci
Keyword(s):  
Islet Cell ◽  
Islet Cell Tumor ◽  
Distinct Type ◽  
Cell Tumor ◽  
Cell Adenoma

scholarly journals Non-islet-cell tumor hypoglycemia as first manifestation of an advanced hepatocellular carcinoma

2021 ◽  
Author(s):  
Imen Rojbi ◽  
Wiem Ben Elhaj ◽  
Nadia Mchirgui ◽  
myriam jrad ◽  
Ibtissem Ben Nacef ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Severe Hypoglycemia ◽  
Clinical Work ◽  
Cell Tumor ◽  
Severe Complication ◽  
Advanced Hepatocellular Carcinoma ◽  
Tumor Hypoglycemia

Non-islet cell tumor hypoglycemia (NICTH) is a rare but severe complication of malignancy. We present the case of 55 year old man who was admitted for severe hypoglycemia. The diagnosis of insulinoma was ruled out. After clinical work-ups, we made the diagnosis of metastatic HCC with production of IGF-2.

Congenital Islet Cell Adenoma Causing Hypoglycemia in a Newborn

PEDIATRICS ◽  
1971 ◽  
Vol 47 (3) ◽  
pp. 605-610
Author(s):  
Neil R. M. Buist ◽  
John R. Campbell ◽  
Albert Castro ◽  
Bolek Brant
Keyword(s):  
Glucose Tolerance ◽  
Islet Cell ◽  
Plasma Insulin ◽  
Islet Cell Tumor ◽  
Pancreatic Tissue ◽  
Cell Tumor ◽  
Cell Adenoma ◽  
Normal Pancreatic Tissue ◽  
Glucose Ratio ◽  
Glucose Tolerance Tests

Hypoglycemia caused by an islet cell tumor of the pancreas has been reported in only a few newborn babies.1-7 This paper presents another case in whom the hypoglycemia was severe and resistant to all forms of medical therapy, including 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1, 1-dioxide (Diazoxide). Hyperinsulinemia was not found but the plasma insulin/glucose ratio was inappropriately high while the patient was hypoglycemic. The hypoglycemia was cured by removal of the tumor at the age of 4 months. Insulin levels in the tumor and in the normal pancreatic tissue are also reported. Methods Glucose tolerance tests were performed using 2.5 gm/kg glucose given as a 25% solution by gavage over 5 minutes.

scholarly journals Severe Hypoglycemia Induced by IGF-II Producing Non-Islet Cell Tumor

2007 ◽  
Vol 46 (13) ◽  
pp. 1061-1061 ◽  
Author(s):  
Motoko Kanzaki ◽  
Hiromi Kashihara ◽  
Katsuyuki Kiura ◽  
Kazutoshi Murakami ◽  
Hiromi Iwagaki ◽  
...  
Keyword(s):  
Islet Cell ◽  
Islet Cell Tumor ◽  
Severe Hypoglycemia ◽  
Cell Tumor

Suppression and stimulation mechanisms controlling glucagon secretion in a case of islet-cell tumor producing glucagon, insulin, and gastrin

Diabetes ◽  
1976 ◽  
Vol 25 (5) ◽  
pp. 408-412 ◽  
Author(s):  
A. Tiengo ◽  
D. Fedele ◽  
E. Marchiori ◽  
R. Nosadini ◽  
M. Muggeo
Keyword(s):  
Islet Cell ◽  
Islet Cell Tumor ◽  
Glucagon Secretion ◽  
Cell Tumor
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