Early Childhood Pneumonia and Impaired Adult Lung Function

2015 ◽  
Vol 34 (2) ◽  
pp. 18-18
Author(s):  
R. M. Wardrop
Keyword(s):  
Early Childhood ◽  
Lung Function ◽  
Childhood Pneumonia ◽  
Adult Lung

scholarly journals Associations between birth weight, early childhood weight gain and adult lung function

Thorax ◽  
2009 ◽  
Vol 64 (3) ◽  
pp. 228-232 ◽  
Author(s):  
R J Hancox ◽  
R Poulton ◽  
J M Greene ◽  
C R McLachlan ◽  
M S Pearce ◽  
...  
Keyword(s):  
Early Childhood ◽  
Weight Gain ◽  
Birth Weight ◽  
Lung Function ◽  
Adult Lung ◽  
Childhood Weight

scholarly journals Relation of early childhood growth and wheezing phenotypes to adult lung function

2011 ◽  
Vol 46 (10) ◽  
pp. 956-963 ◽  
Author(s):  
Duane L. Sherrill ◽  
Stefano Guerra ◽  
Anne L. Wright ◽  
Wayne J. Morgan ◽  
Fernando D. Martinez
Keyword(s):  
Early Childhood ◽  
Lung Function ◽  
Childhood Growth ◽  
Adult Lung

scholarly journals Early Childhood Pneumonia Is Associated with Reduced Lung Function and Asthma in First Nations Australian Children and Young Adults

2021 ◽  
Vol 10 (24) ◽  
pp. 5727
Author(s):  
Andrew J. Collaro ◽  
Anne B. Chang ◽  
Julie M. Marchant ◽  
Mark D. Chatfield ◽  
Don Vicendese ◽  
...  
Keyword(s):  
At Risk ◽  
Early Childhood ◽  
Young Adults ◽  
Lung Function ◽  
First Nations ◽  
Early Adulthood ◽  
Cross Sectional ◽  
Childhood Pneumonia ◽  
Increased Risk ◽  
Z Scores

Background: Some but not all previous studies report that pneumonia in children aged less than five years is associated with lower lung function and elevated risk of respiratory disease. To date, none have explored these associations in at-risk populations such as First Nations Australians, whose incidence of early childhood pneumonia is among the highest reported in the world. Methods: This cross-sectional study included 1276 First Nations Australian children/young adults aged 5–25 years recruited from regional/remote Queensland and Northern Territory communities and schools. Associations between pneumonia and both spirometry values and asthma were investigated using linear and logistic regression. Results: Early childhood pneumonia was associated with lower FEV1 and FVC Z-scores, but not FEV1/FVC% Z-scores, when occurring before age three (FEV1 β = −0.42, [95%CI −0.79, −0.04]; FVC β = −0.62, [95%CI −1.14, −0.09]), and between three and five years (β = −0.50, [95%CI −0.88, −0.12]; β = −0.63, [95%CI −1.17, −0.10]), compared to those who never had pneumonia. Similarly, pneumonia occurring when aged before age three years (OR = 3.68, 95%CI 1.96–6.93) and three to five years (OR = 4.81, 95%CI 1.46–15.8) was associated with increased risk of asthma in later childhood. Conclusions: Early childhood pneumonia is associated with lung function deficits and increased asthma risk in later childhood/early adulthood in First Nations Australians. The disproportionate impact of pneumonia on at-risk children must be addressed as a priority.

scholarly journals Association of prenatal and early childhood stress with reduced lung function in 7-year-olds

2017 ◽  
Vol 119 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Alison G. Lee ◽  
Yueh-Hsiu M. Chiu ◽  
Maria J. Rosa ◽  
Sheldon Cohen ◽  
Brent A. Coull ◽  
...  
Keyword(s):  
Early Childhood ◽  
Lung Function ◽  
Childhood Stress

scholarly journals Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD

2020 ◽  
Vol 56 (4) ◽  
pp. 1902347
Author(s):  
Priyadarshini Kachroo ◽  
Jarrett D. Morrow ◽  
Alvin T. Kho ◽  
Carrie A. Vyhlidal ◽  
Edwin K. Silverman ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Lung Function ◽  
Lung Tissue ◽  
Gestational Age ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Fetal Lung ◽  
Developmental Origins ◽  
Fetal Origins ◽  
Adult Lung

COPD likely has developmental origins; however, the underlying molecular mechanisms are not fully identified. Investigation of lung tissue-specific epigenetic modifications such as DNA methylation using network approaches might facilitate insights linking in utero smoke (IUS) exposure and risk for COPD in adulthood.We performed genome-wide methylation profiling for adult lung DNA from 160 surgical samples and 78 fetal lung DNA samples isolated from discarded tissue at 8–18 weeks of gestation. Co-methylation networks were constructed to identify preserved modules that shared methylation patterns in fetal and adult lung tissues and associations with fetal IUS exposure, gestational age and COPD.Weighted correlation networks highlighted preserved and co-methylated modules for both fetal and adult lung data associated with fetal IUS exposure, COPD and lower adult lung function. These modules were significantly enriched for genes involved in embryonic organ development and specific inflammation-related pathways, including Hippo, phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), Wnt, mitogen-activated protein kinase and transforming growth factor-β signalling. Gestational age-associated modules were remarkably preserved for COPD and lung function, and were also annotated to genes enriched for the Wnt and PI3K/AKT pathways.Epigenetic network perturbations in fetal lung tissue exposed to IUS and of early lung development recapitulated in adult lung tissue from ex-smokers with COPD. Overlapping fetal and adult lung tissue network modules highlighted putative disease pathways supportive of exposure-related and age-associated developmental origins of COPD.

scholarly journals On Genetics, Lung Developmental Biology, and Adult Lung Function

2020 ◽  
Vol 202 (6) ◽  
pp. 791-793 ◽  
Author(s):  
Erik Melén ◽  
Gerard H. Koppelman ◽  
Stefano Guerra
Keyword(s):  
Developmental Biology ◽  
Lung Function ◽  
Adult Lung
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