scholarly journals PHARMACOLOGICAL BLOCKADE OF PROTEASE-ACTIVATED RECEPTORS 1 NORMALIZES BEHAVIORAL HYPEREXCITABILITY OF RATS IN THE LATENT STAGE OF THE EXPERIMENTAL MODEL OF TEMPORAL LOBE EPILEPSY

2019 ◽  
Vol 65 (3) ◽  
pp. 7-11 ◽  
Author(s):  
M. Semenikhina ◽  
◽  
R. Bogovik ◽  
M. Fedoryuk ◽  
О. Lunko ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Experimental Model ◽  
Temporal Lobe ◽  
Protease Activated Receptors ◽  
Latent Stage ◽  
Pharmacological Blockade

scholarly journals THE EFFECT OF PROTEASE-ACTIVATED RECEPTORS 1 INHIBITION ON DEPRESSIVE-LIKE BEHAVIOR IN THE LATENT STAGE OF FORMATION OF TEMPORAL LOBE EPILEPSY

2020 ◽  
Vol 66 (5) ◽  
pp. 17-22
Author(s):  
М. Semenikhina ◽  
◽  
M. Fedoryuk ◽  
R. Bogovik ◽  
◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Forced Swim Test ◽  
Preference Test ◽  
Control Group ◽  
Protease Activated Receptors ◽  
Swim Test ◽  
Latent Stage ◽  
Forced Swim ◽  
Pilocarpine Model

Here we investigate the effect of pharmacological blockade of protease-activated receptors 1 (PAR1) on depressive-like behavioral impairments following status epilepticus (SE). Behavioral tests were performed during the latent stage of formation of temporal lobe epilepsy two weeks after SE induced using lithium-pilocarpine model. The PAR1 blocker (SCH 79797) was injected for 10 days after SE. The results indicate a partial normalization of depressive-like behavior in the forced swim test: the climbing time was 180 s after PAR1 inhibition, and 87 s after SE). We also observed behavioral normalization after PAR1 inhibition in the sucrose test. PAR1 inhibition led to the normalization of climbing time in the forced swim test, as well as normalized the behavior in the sucrose preference test. At the same time, the swimming time in the forced swim test decreased due to the PAR1 inhibition compared to the control group, while the floating time increased.

Modulation of Seizures and Synaptic Plasticity by Adenosinergic Receptors in an Experimental Model of Temporal Lobe Epilepsy Induced by Pilocarpine in Rats

Epilepsia ◽  
2005 ◽  
Vol 46 (s5) ◽  
pp. 166-173 ◽  
Author(s):  
Eduardo Paulo Morowsky Vianna ◽  
Alice Teixeira Ferreira ◽  
Flavia Dona ◽  
Esper Abrao Cavalheiro ◽  
Maria Jose da Silva Fernandes
Keyword(s):  
Synaptic Plasticity ◽  
Temporal Lobe Epilepsy ◽  
Experimental Model ◽  
Temporal Lobe

Analysis of the acute neuroinflammatory response and endogenous markers in the amygdala of animals submitted to status epilepticus by intrahippocampal pilocarpine application

2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Vinicius Lisboa Da Rocha ◽  
Amanda Pinato Alves da Costa ◽  
Amanda Feltrin Lisboa ◽  
Enzo Da Silva Salmazo ◽  
Emanoel de Oliveira Araújo ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Temporal Lobe Epilepsy ◽  
Experimental Model ◽  
Temporal Lobe ◽  
Inflammatory Process ◽  
Epileptic Seizures ◽  
Immunohistochemical Analysis ◽  
Sterile Saline ◽  
Male Wistar Rats ◽  
The Right

Introduction: Experimental evidence and clinical evidence indicate that the inflammatory process is a crucial mechanism in the pathophysiology of epileptic seizures and temporal lobe epilepsy. The amygdala when involved in an atypical processing is associated with multiple moods such as depression and anxiety disorder and psychiatric disorders such as schizophrenia. Objective: This study investigated the acute inflammatory process and modulation of the endogenous proteins’ galectins and AnxA1 in the amygdala of animals submitted to an experimental model of temporal lobe epilepsy. Methods: The experimental procedures were approved by the Ethics Committee on the Use of Animals at UNIFESP (CEUA nº2958050814). The experiments performed in this study used data and materials that were obtained from the project “Neuroprotective and anti-inflammatory role of the mimetic peptide ac2-26 of the annexin a1 protein in intrahippocampal pilocarpine-induced status epilepticus” conducted by the advisor. The experimental model used male Wistar rats that were divided into 3 experimental groups (NAIVE; SHAM, Status Epilepticus or SE - n = 5 animals/group). Once acclimated, the animals in the SHAM and SE groups underwent stereotaxic surgery for implantation of the intracerebral cannula in the right hippocampus. The SHAM animals received sterile saline in all procedures and the NAIVE group only manipulated. The animals were monitored throughout the period and after 24 hours of experiment all animals were euthanized by overdose of thiopental to remove the brain and performed histological and immunohistochemical analysis. Results and Conclusion: Initial results demonstrate that SE and the acute inflammatory process cause damage to the amygdala, and there is also modulation of inflammatory markers in this structure. However, further studies are needed to better understand the mechanism of action in neuroinflammation in status epilepticus.

scholarly journals PHARMACOLOGICAL BLOCKADE OF ACID SENSING ION CHANNELS NORMALIZES EMOTIONALLY CONDITIONED LEARNING DISTURBED DUE TO EPILEPTIC STATUS

2020 ◽  
Vol 66 (5) ◽  
pp. 11-16
Author(s):  
M.P. Fedoriuk ◽  
◽  
M.V. Stefanenko ◽  
R.I. Bohovyk ◽  
A.O. Cherninsky ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Ion Channels ◽  
Temporal Lobe Epilepsy ◽  
Emotional Disorders ◽  
Temporal Lobe ◽  
Emotional Learning ◽  
Acid Sensing Ion Channels ◽  
Positive Therapeutic Effect ◽  
Conditioned Learning ◽  
Pharmacological Blockade

The effect of pharmacological blockade of ASIC1a channels on emotionally conditioned learning in rats with lithiumpilocarpine model of temporal lobe epilepsy was studied. The development of status epilepticus is known to impair both contextual and stimulated emotional learning. In our experiments, the painful effect was directly accompanied by freezing in animals of all groups, however, under conditions of induced epilepsy, its duration was shorter, and blocking ASIC1a channels neutralized this difference. The induction of epilepsy disrupted both contextual and stimulated emotional learning. Suppression of ASIC1a channels partially restored this process in animals with induced epilepsy. This means that pharmacological blocking of ASIC1a channels can have a positive therapeutic effect in correcting the emotional disorders associated with temporal lobe epilepsy.

Malnutrition in Infancy as a Susceptibility Factor for Temporal Lobe Epilepsy in Adulthood Induced by the Pilocarpine Experimental Model

2011 ◽  
Vol 33 (6) ◽  
pp. 469-478 ◽  
Author(s):  
Francisco Romero Cabral ◽  
Margareth Rose Priel ◽  
Bruno Henrique Silva Araujo ◽  
Laila Brito Torres ◽  
Eliangela de Lima ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Experimental Model ◽  
Temporal Lobe ◽  
Susceptibility Factor

The immunosuppressant cyclosporin A inhibits recurrent seizures in an experimental model of temporal lobe epilepsy

2012 ◽  
Vol 529 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Seungmoon Jung ◽  
Hyunwoo Yang ◽  
Byung Sun Kim ◽  
Kon Chu ◽  
Sang Kun Lee ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Cyclosporin A ◽  
Experimental Model ◽  
Temporal Lobe
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