Malnutrition in Infancy as a Susceptibility Factor for Temporal Lobe Epilepsy in Adulthood Induced by the Pilocarpine Experimental Model

2011 ◽  
Vol 33 (6) ◽  
pp. 469-478 ◽  
Author(s):  
Francisco Romero Cabral ◽  
Margareth Rose Priel ◽  
Bruno Henrique Silva Araujo ◽  
Laila Brito Torres ◽  
Eliangela de Lima ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Experimental Model ◽  
Temporal Lobe ◽  
Susceptibility Factor

Modulation of Seizures and Synaptic Plasticity by Adenosinergic Receptors in an Experimental Model of Temporal Lobe Epilepsy Induced by Pilocarpine in Rats

Epilepsia ◽  
2005 ◽  
Vol 46 (s5) ◽  
pp. 166-173 ◽  
Author(s):  
Eduardo Paulo Morowsky Vianna ◽  
Alice Teixeira Ferreira ◽  
Flavia Dona ◽  
Esper Abrao Cavalheiro ◽  
Maria Jose da Silva Fernandes
Keyword(s):  
Synaptic Plasticity ◽  
Temporal Lobe Epilepsy ◽  
Experimental Model ◽  
Temporal Lobe

Analysis of the acute neuroinflammatory response and endogenous markers in the amygdala of animals submitted to status epilepticus by intrahippocampal pilocarpine application

2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Vinicius Lisboa Da Rocha ◽  
Amanda Pinato Alves da Costa ◽  
Amanda Feltrin Lisboa ◽  
Enzo Da Silva Salmazo ◽  
Emanoel de Oliveira Araújo ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Temporal Lobe Epilepsy ◽  
Experimental Model ◽  
Temporal Lobe ◽  
Inflammatory Process ◽  
Epileptic Seizures ◽  
Immunohistochemical Analysis ◽  
Sterile Saline ◽  
Male Wistar Rats ◽  
The Right

Introduction: Experimental evidence and clinical evidence indicate that the inflammatory process is a crucial mechanism in the pathophysiology of epileptic seizures and temporal lobe epilepsy. The amygdala when involved in an atypical processing is associated with multiple moods such as depression and anxiety disorder and psychiatric disorders such as schizophrenia. Objective: This study investigated the acute inflammatory process and modulation of the endogenous proteins’ galectins and AnxA1 in the amygdala of animals submitted to an experimental model of temporal lobe epilepsy. Methods: The experimental procedures were approved by the Ethics Committee on the Use of Animals at UNIFESP (CEUA nº2958050814). The experiments performed in this study used data and materials that were obtained from the project “Neuroprotective and anti-inflammatory role of the mimetic peptide ac2-26 of the annexin a1 protein in intrahippocampal pilocarpine-induced status epilepticus” conducted by the advisor. The experimental model used male Wistar rats that were divided into 3 experimental groups (NAIVE; SHAM, Status Epilepticus or SE - n = 5 animals/group). Once acclimated, the animals in the SHAM and SE groups underwent stereotaxic surgery for implantation of the intracerebral cannula in the right hippocampus. The SHAM animals received sterile saline in all procedures and the NAIVE group only manipulated. The animals were monitored throughout the period and after 24 hours of experiment all animals were euthanized by overdose of thiopental to remove the brain and performed histological and immunohistochemical analysis. Results and Conclusion: Initial results demonstrate that SE and the acute inflammatory process cause damage to the amygdala, and there is also modulation of inflammatory markers in this structure. However, further studies are needed to better understand the mechanism of action in neuroinflammation in status epilepticus.

The immunosuppressant cyclosporin A inhibits recurrent seizures in an experimental model of temporal lobe epilepsy

2012 ◽  
Vol 529 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Seungmoon Jung ◽  
Hyunwoo Yang ◽  
Byung Sun Kim ◽  
Kon Chu ◽  
Sang Kun Lee ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Cyclosporin A ◽  
Experimental Model ◽  
Temporal Lobe

scholarly journals Hippocampal-Dependent Spatial Memory in the Water Maze is Preserved in an Experimental Model of Temporal Lobe Epilepsy in Rats

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e22372 ◽  
Author(s):  
Marion Inostroza ◽  
Elena Cid ◽  
Jorge Brotons-Mas ◽  
Beatriz Gal ◽  
Paloma Aivar ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Spatial Memory ◽  
Experimental Model ◽  
Temporal Lobe ◽  
Water Maze

The Role of the Estrogen Replacement in Patophysiology in an Experimental Model of Temporal Lobe Epilepsy

1999 ◽  
Vol 6 (4) ◽  
pp. 350-351
Author(s):  
S G Valente ◽  
M Pereira ◽  
I Silva ◽  
M A Haidar ◽  
M G Naffah-Mazzacoratti ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Experimental Model ◽  
Temporal Lobe ◽  
Estrogen Replacement
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