scholarly journals Magnetic-laser influence on the system of nitric oxide and contractile activity of smooth muscles of rat aorta under hypertension

2012 ◽  
Vol 58 (6) ◽  
pp. 36-47
Author(s):  
SM Fedorov ◽  
◽  
OV Baziliuk ◽  
AV Kotsiuruba ◽  
IuP Korkach ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Contractile Activity ◽  
Smooth Muscles ◽  
Rat Aorta

scholarly journals Hydrogen peroxide influence on contractile activity smooth muscle cells: the role of cytoskeleton

2009 ◽  
Vol 8 (4) ◽  
pp. 41-46
Author(s):  
I. V. Kovalyev ◽  
S. V. Gusakova ◽  
O. S. Melnik ◽  
M. B. Baskakov ◽  
L. V. Kapilevich ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Contractile Activity ◽  
Smooth Muscles ◽  
Potassium Conductance ◽  
Muscle Cells ◽  
Rat Aorta ◽  
Mechanisms Of Action

The influence of of hydrogen peroxide on the contractile reactions of smooth muscle cells caused by hyperpotassium solution end phenylephrine in modulation a potassium conductance the membrane and the state of cytoskeleton elements has been investigated by the mechanographical method. It has multidirectional influence of hydrogen peroxide in the reduction of smooth muscles of rat aorta with the membrane depolarization hyperpotassium solution and action phenylephrine: phenylephrine decline in value and increase strength hyperpotassium contractures. We show that the cytoskeleton components involved in the mechanisms of action of hydrogen peroxide in the contractile reactions of smooth muscles of rat aorta caused by phenylephrine.

scholarly journals Evaluation of the Possible Mechanisms of Antihypertensive Activity ofLoranthus micranthus: An African Mistletoe

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Bamidele A. Iwalokun ◽  
Sedoten A. Hodonu ◽  
Stella Nwoke ◽  
Olabisi Ojo ◽  
Phillip U. Agomo
Keyword(s):  
Nitric Oxide ◽  
Serum Lipid ◽  
Smooth Muscles ◽  
Inhibitory Effect ◽  
Rat Aorta ◽  
Lipid Profiles ◽  
Antihypertensive Activity ◽  
Ring Model ◽  
Aorta Ring ◽  
Hypertensive Activity

Loranthus micranthus (LM), also called African mistletoe is a major NigerianLoranthaceaeplant used traditionally to treat hypertension. The methanolic leaf extract of the plant (LMME) has been shown to elicit anti-hypertensive activity in rats but mechanism remains unclear. This study was undertaken to study the effect of LM on pressor-induced contraction of rat aorta smooth muscles and serum lipid profiles in mice. The LMME was partitioned to produce n-butanol (NBF-LMME), chloroform (CF-LMME), ethyl acetate (EAF-LMME) and water (WF-LMME) fractions. The median effective concentrations and maximum relaxation of the fractions were determined against epinephrine and KCl pre-contracted rat aorta ring model. Serum lipid profiles and nitric oxide (NO) were determined spectrophotometrically in mice administered per orally 250 mg/kg b.w. of each fraction for 21 days. Data were analyzed statistically. NBF-LMME elicited the highest dose-dependent inhibitory effect on rat aorta pre-contracted with norepinephrine and KCl, followed in decreasing order by WF-LMME > CF-LMME > EAF-LMME. Similar order of activity was observed in the ability of these fractions to inhibit elevation in artherogenic lipids, raise serum nitric oxide and reduce cardiac arginase in mice. We conclude the anti-hypertensive activity ofL. micranthusinvolve anti-artherogenic events, vasorelaxation, cardiac arginase reduction and NO elevation.

scholarly journals Role of nitric oxide and cytoskeleton in regulation of contractile activity smooth muscle cells

2009 ◽  
Vol 8 (3) ◽  
pp. 17-22
Author(s):  
S. V. Gusakova ◽  
M. B. Baskakov ◽  
I. V. Kovalev ◽  
O. S. Melnik ◽  
L. V. Kapilevich ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Sodium Nitroprusside ◽  
Contractile Activity ◽  
Muscle Cells ◽  
Rat Aorta

The influence of modulation of cytoskeleton by colchicine, nocodazole and cytochalasine D on contractile reactions of smooth muscle cells caused by depolarization, phenylephrine end sodium nitroprusside has been investigated by the mechanographical method. It was found that the reduction in smooth muscle cells of rat aorta caused by fenilefrin more sensitive to sodium nitroprusside than the reduction induced hyperpotassium solution. We show that microtubules involved in relaxation, indirect nitric oxide of smooth muscle in hyperpotassium solution, whereas the efficiency of relaxing influence of nitric oxide in rat aorta smooth muscle in the action depends on phenylephrine and microfilaments and microtubules.

scholarly journals Quercetin relaxes human gastric smooth muscles directly through ATP‐sensitive potassium channels and not depending on the nitric oxide pathway

2021 ◽  
Author(s):  
Beata Modzelewska ◽  
Krzysztof Drygalski ◽  
Tomasz Kleszczewski ◽  
Andrzej Chomentowski ◽  
Krzysztof Koryciński ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Potassium Channels ◽  
Smooth Muscles ◽  
Nitric Oxide Pathway

Involvement of nitric oxide in extrinsic nervous control of ileal contractile activity

1998 ◽  
Vol 47 (2) ◽  
pp. 151-154 ◽  
Author(s):  
Zlatka Mizhorkova ◽  
Elissaveta Milusheva ◽  
Maria Papasova
Keyword(s):  
Nitric Oxide ◽  
Contractile Activity ◽  
Nervous Control

The Presence of the Endothelial Layer Reduces Nitric Oxide–Induced Hyporesponsiveness to Phenylephrine in Rat Aorta

Endothelium ◽  
2004 ◽  
Vol 11 (3-4) ◽  
pp. 181-187 ◽  
Author(s):  
Márcia Ribeiro Terluk ◽  
Emiliana Domingues Cunha da Silva ◽  
Tayze Tatiana Antunes ◽  
Jamil Assreuy
Keyword(s):  
Nitric Oxide ◽  
Rat Aorta ◽  
Endothelial Layer
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