scholarly journals Phase changes in energy metabolism during periodic hypoxia

2012 ◽  
Vol 58 (4) ◽  
pp. 3-12 ◽  
Author(s):  
VI Portnichenko ◽  
◽  
VI Nosar' ◽  
AG Portnichenko ◽  
TI Drevitskaia ◽  
...  
Author(s):  
Vladimir I. Portnichenko ◽  
Valentina I. Nosar ◽  
Alla G. Portnychenko ◽  
Tatyana I. Drevitskaya ◽  
Alla M. Sydorenko ◽  
...  

Author(s):  
Volodymyr I. Portnichenko ◽  
Valentina I. Nosar ◽  
Olga A. Gonchar ◽  
Anna V. Opanasenko ◽  
Irina N. Mankovskaya

2021 ◽  
Vol 4 ◽  
pp. 8-15
Author(s):  
А. Kydyrmoldina ◽  
B. Zhetpisbayev ◽  
A. Utegenova ◽  
E. Omarkhanova ◽  
M. Malik ◽  
...  

The aim of the study was to study changes in immunological reactivity and biochemical processes in peripheral blood lymphocytes in Pakistani students under the action of muscle stress. To achieve this goal, the states of the immune, lipid peroxidation and antioxidant systems and energy metabolism were studied in 30 students from South Asia under the influence of muscle stress. The state of cellular, humoral and nonspecific phagocytic immunity was determined in all students before and 1, 2 and 3 days after the stress of muscle load. The research results show that the state of the immune system after muscle stress was characterized by phase changes in the parameters of cellular, humoral and nonspecific phagocytic immunity with a restoration or increase in indicators at the end of the observation. An increase in the activity of enzymes of energy metabolism in peripheral blood lymphocytes after stress of muscular load on days 2 and 3 after ensures the processes of successful adaptation. The state of lipid peroxidation and the antioxidant system in peripheral blood lymphocytes under muscle stress reflects the stress of the organism's adaptive reactions with the development of lipid hyperperoxidation under conditions of increased energy costs.


2014 ◽  
Vol 60 (5) ◽  
pp. 23-32
Author(s):  
VI Portnichenko ◽  
◽  
VI Nosar ◽  
OO Honchar ◽  
HV Opanasenko ◽  
...  

Author(s):  
J. M. Cowley ◽  
Sumio Iijima

The imaging of detailed structures of crystal lattices with 3 to 4Å resolution, given the correct conditions of microscope defocus and crystal orientation and thickness, has been used by Iijima (this conference) for the study of new types of crystal structures and the defects in known structures associated with fluctuations of stoichiometry. The image intensities may be computed using n-beam dynamical diffraction theory involving several hundred beams (Fejes, this conference). However it is still important to have a suitable approximation to provide an immediate rough estimate of contrast and an evaluation of the intuitive interpretation in terms of an amplitude object.For crystals 100 to 150Å thick containing moderately heavy atoms the phase changes of the electron wave vary by about 10 radians suggesting that the “optimum defocus” theory of amplitude contrast for thin phase objects due to Scherzer and others can not apply, although it does predict the right defocus for optimum imaging.


Author(s):  
W.A. Jacob ◽  
R. Hertsens ◽  
A. Van Bogaert ◽  
M. De Smet

In the past most studies of the control of energy metabolism focus on the role of the phosphorylation potential ATP/ADP.Pi on the regulation of respiration. Studies using NMR techniques have demonstrated that the concentrations of these compounds for oxidation phosphorylation do not change appreciably throughout the cardiac cycle and during increases in cardiac work. Hence regulation of energy production by calcium ions, present in the mitochondrial matrix, has been the object of a number of recent studies.Three exclusively intramitochondnal dehydrogenases are key enzymes for the regulation of oxidative metabolism. They are activated by calcium ions in the low micromolar range. Since, however, earlier estimates of the intramitochondnal calcium, based on equilibrium thermodynamic considerations, were in the millimolar range, a physiological correlation was not evident. The introduction of calcium-sensitive probes fura-2 and indo-1 made monitoring of free calcium during changing energy metabolism possible. These studies were performed on isolated mitochondria and extrapolation to the in vivo situation is more or less speculative.


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