MIGRATION OF WEST SIBERIAN POPULATION IN 1950-1970: CAUSES AND CONSEQUENCES

Abstract Background Consumption of polyphenolic compounds from various food sources is associated with a reduction in cardiovascular risk factors. The region of residence, the food habits of the population, and age have a significant impact on consumption. Methods Participants: the Siberian urban population (Novosibirsk, HAPIEE study, 9324 (4,249 men and 5,075 women) aged 45-69. Dietary data collected using a 141-item food frequency questionnaire. Data on the polyphenols were taken from the Phenol-Explorer database (3.6). Total polyphenols (TPH) were considered as a sum of all individual classes: flavonoids, phenolic acids, stilbenes, lignans and other polyphenols and their food sources. The consumption of polyphenolic compounds in the age groups of 45-49, 50-54, 55-59, 60-64 and more than 65 years was analyzed. To assess the relationship between CVD risk factors and the consumption of TPH, the odds ratio was calculated in quartiles of TPH consumption (OR). Results The consumption of TPH in men was 1273 (647) and 1203 (626) mg/day in women (P < 0,05). The main class for both men and women were flavonoids, as well as phenolic acids. For men, respectively, 68 and 21% of the total consumption of TPH, for women 70 and 20%. Chances of developing hypertension in quartiles of high and low consumption of TPH showed a risk reduction in whole population by 58%, in quartiles of high and low consumption of total flavonoids - by 56% and phenolic acids - by 21%. The main sources of TPH were tea, coffee, fruits, vegetables and rye bread. With increasing age, both men and women experience a decrease in TPH consumption by 9.5 and 11%, respectively, of flavonoids - by 10.6 and 15%. This is due to a decrease in fruit consumption with increasing age. Conclusions The consumption of polyphenol compounds in the Siberian urban population associated with reduction of hypertension and determined by age. The study was carried out in the framework of budget theme No. AAAA-A17-117112850280-2. Key messages Consumption of polyphenolic compounds in the Siberian population is associated with a reduced risk of hypertension. In recommendations for the prevention of hypertension in the older age group, it is necessary to consider the increase in the consumption of fruits and berries from local sources.

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Association of rs3025058 polymorphism with the development of acute cerebrovascular event

European Heart Journal ◽

10.1093/eurheartj/ehab724.2052 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

A Chernova ◽

S Nikulina ◽

D Nikulin

Keyword(s):

Risk Factors ◽

Genetic Research ◽

Statistical Processing ◽

Main Group ◽

Control Group ◽

Cerebrovascular Event ◽

Siberian Population ◽

Cardiovascular Pathology ◽

Daily Monitoring ◽

Arterial Blood

Abstract Purpose To study SNP rs3025058 association (5a/6a) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results In all analyzed groups and subgroups of patients statistically significant connection between a genotype of 5a/5a and an allele of 5a and in subgroup of women with Acute Cerebrovascular Event, subgroups of patients with AG and hypercoagulation of significant associations of polymorphism rs3025058 (5a/6a) with Acute Cerebrovascular Eventis not revealed. Conclusion A genotype 5a/5a and an allele 5a SNP rs3025058 (5a/6a) increase risk of development of an Acute Cerebrovascular Event in persons of the east Siberian population, including with such risk factors as atherosclerosis the brachiocephalic of arteries and a dislipidemiya. FUNDunding Acknowledgement Type of funding sources: None.

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MtDNA Haplogroup A10 Lineages in Bronze Age Samples Suggest That Ancient Autochthonous Human Groups Contributed to the Specificity of the Indigenous West Siberian Population

PLoS ONE ◽

10.1371/journal.pone.0127182 ◽

2015 ◽

Vol 10 (5) ◽

pp. e0127182 ◽

Cited By ~ 6

Author(s):

Aleksandr S. Pilipenko ◽

Rostislav O. Trapezov ◽

Anton A. Zhuravlev ◽

Vyacheslav I. Molodin ◽

Aida G. Romaschenko

Keyword(s):

Bronze Age ◽

Siberian Population ◽

Mtdna Haplogroup

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Tracing back ancient south Siberian population history using mitochondrial and Y-chromosome SNPs

Forensic Science International Genetics Supplement Series ◽

10.1016/j.fsigss.2007.10.133 ◽

2008 ◽

Vol 1 (1) ◽

pp. 343-345 ◽

Cited By ~ 3

Author(s):

Christine Keyser ◽

Sarah Romac ◽

Caroline Bouakaze ◽

Sylvain Amory ◽

Eric Crubézy ◽

...

Keyword(s):

Y Chromosome ◽

Population History ◽

Siberian Population

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Association of functional −509C>T polymorphism in the TGF-β1 gene with infiltrating ductal breast carcinoma risk in a Russian Western Siberian population

Cancer Epidemiology ◽

10.1016/j.canep.2011.02.002 ◽

2011 ◽

Vol 35 (6) ◽

pp. 560-563 ◽

Cited By ~ 4

Author(s):

Nataliya Babyshkina ◽

Elena Malinovskaya ◽

Marina Stakheyeva ◽

Victor Volkomorov ◽

Elena Slonimskaya ◽

...

Keyword(s):

Breast Carcinoma ◽

Siberian Population ◽

Ductal Breast Carcinoma ◽

Tgf Β1 ◽

Carcinoma Risk

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Genetic polymorphisms of CYP2D6, CYP1A1, GSTM1 and p53 genes in a unique Siberian population of Tundra Nentsi

Pharmacogenetics ◽

10.1097/00008571-200008000-00006 ◽

2000 ◽

Vol 10 (6) ◽

pp. 531-537 ◽

Cited By ~ 5

Author(s):

T. Duzhak ◽

D. Mitrofanov ◽

V. Ostashevskii ◽

N. Gutkina ◽

O. Chasovnikova ◽

...

Keyword(s):

Genetic Polymorphisms ◽

Siberian Population ◽

P53 Genes

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Developing STR databases on structured populations: The native South Siberian population versus the Russian population

Forensic Science International Genetics ◽

10.1016/j.fsigen.2008.08.001 ◽

2009 ◽

Vol 3 (4) ◽

pp. e111-e116 ◽

Cited By ~ 15

Author(s):

Lev A. Zhivotovsky ◽

Boris A. Malyarchuk ◽

Miroslava V. Derenko ◽

Marcin Wozniak ◽

Tomasz Grzybowski

Keyword(s):

Russian Population ◽

Structured Populations ◽

Siberian Population

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LONG-TERM TRENDS OF THE MAIN BLOOD LIPID PARAMETERS IN SIBERIAN POPULATION

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2014-3-32-35 ◽

2014 ◽

Vol 13 (3) ◽

pp. 32-35

Author(s):

Yu. P. Nikitin ◽

S. K. Malyutina ◽

K. V. Makarenkova

Keyword(s):

Lipid Profile ◽

Population Analysis ◽

Blood Lipid ◽

Siberian Population ◽

Blood Lipid Profile ◽

Long Term Trends ◽

The Absolute ◽

Lipid Parameters ◽

Representative Samples

Aim. To carry out the population analysis of blood lipid profile trends during the period from 1985 to 2005 in Novosibirsk population.Material and methods. The study was carried out based on the databases of two large international epidemiological projects done in Novosibirsk, WHO “MONIСA” and “HAPIEЕ”. The representative samples from nonorganized population of Novosibirsk were tested in compliance with protocol of the projects. The analysis included data of 10272 people aged from 45 to 64 years; among them 4783 were men and 5489 — women.Results. Blood TC, non-HDL–C and LDL–С levels from the citizens of Novosibirsk aged 45–64 were significantly lower in the year 1995: 5,50±0,03 mM/l, 4,07±0,03 and 3,48±0,03 mM/l, respectively. By 2005 these values increased significantly and became higher than those initial in 1985. For women 20-year changes in TC, non-HDL–C and LDL–С levels are more prominent than for men. Trends of blood triglyceride levels are analogous to the changes of the indexes described above: average levels were the lowest in 1995 and the highest — in 2005. During a twenty years period the gradual statistically significant increase of blood HDL–C concentrations was noted: in 1985 its concentration was 1,29±0,01 mM/l, in 1995–1,42±0,01 mM/l (p<0,001), in 2005–1,53±0,004 mM/l (p<0,001). HDL–C level for the first decade (1985–1995) increased at average by 10% for the all tenyear period, and for the twenty-year period — by 18,6%, at that for men the increase was more significant (20,2%) than for women (16,4%). By 1995 the absolute values of atherogenicity coefficient decreased significantly; for women in a greater degree. By 2005 the correlation of pro-atherogenic factor to atherogenic one has slightly increased however stayed lower in relation to 1985.Conclusion. In the year 1995 in Siberian population blood TC, non-HDL–C, LDL–С and TG levels appeared to be lower than in 1985 and 2005. Blood HDL–C content was increasing with each decade. Atherogenicity coefficient decreased during the first decade (by 1995), and during the subsequent years slightly increased for women, but did not change significantly for men.

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