Association of functional −509C>T polymorphism in the TGF-β1 gene with infiltrating ductal breast carcinoma risk in a Russian Western Siberian population

2011 ◽  
Vol 35 (6) ◽  
pp. 560-563 ◽  
Author(s):  
Nataliya Babyshkina ◽  
Elena Malinovskaya ◽  
Marina Stakheyeva ◽  
Victor Volkomorov ◽  
Elena Slonimskaya ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Siberian Population ◽  
Ductal Breast Carcinoma ◽  
Tgf Β1 ◽  
Carcinoma Risk

Challenges in the correct assessment of a case of aggressive thyroid carcinoma with synchronous breast cancer, case report and review of the literature: essential role of radiopharmaceuticals

2020 ◽  
Vol 13 ◽  
Author(s):  
Andra Piciu ◽  
Alexandru Mester ◽  
George Rusu ◽  
Doina Piciu
Keyword(s):  
Breast Cancer ◽  
Papillary Thyroid Carcinoma ◽  
Breast Carcinoma ◽  
Thyroid Carcinoma ◽  
Bone Metastases ◽  
Essential Role ◽  
Papillary Thyroid ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma

Background: Thyroid carcinoma represents a complex pathology that can still be considered a medical challenge, despite having a better prognosis and life expectancy than most other neoplasms, also the scenario of multiple malignancies involving thyroid cancer is nowadays a common reality. Materials and methods: We reviewed the literature regarding the aggressive presentation of synchronous thyroid and breast cancer. In the current paper we are reporting the case of a 59 years-old woman, diagnosed with invasive ductal breast carcinoma and papillary thyroid carcinoma, presenting a natural history of both aggressive synchronous tumors. At the moment of hospitalization, the diagnostic was breast carcinoma with multiple secondary lesions, suggestive for lung and bone metastases, and nodular goiter. Results: Searching the literature PUBMED with the terms “thyroid carcinoma and synchronous breast carcinoma we found 86 studies; introducing the term “aggressive” the result included 4 studies, among them none being relevant for aggressive and synchronous. A similar search was done in SCOPUS finding 92 documents and after introducing the term aggressive, the number of papers was 8, none being for the synchronous aggressive metastatic thyroid and breast carcinoma. The majority of imaging diagnostic tools were used in this particular medical case, in order to ensure the best potential outcome. The final diagnostic was papillary thyroid carcinoma with lung and unusual multiple bone metastases and synchronous invasive ductal breast carcinoma with subcutaneous metastases. Conclusion: The case illustrates the challenges in correct assessment of oncologic patients, despite the advances in medical imaging and technologies and underlines the essential role of nuclear medicine procedures in the diagnostic and therapy protocols.

scholarly journals Acute appendicitis as an unusual cause of invasive ductal breast carcinoma metastasis

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Vincent De Pauw ◽  
Julie Navez ◽  
Stephane Holbrechts ◽  
Jean Lemaitre
Keyword(s):  
Abdominal Pain ◽  
Breast Carcinoma ◽  
Acute Appendicitis ◽  
Ductal Carcinoma ◽  
Hormonal Treatment ◽  
Locoregional Therapy ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma ◽  
History Of ◽  
Anticancer Treatment

Abstract Acute appendicitis is one of the most common causes of abdominal pain at the emergency room. In rare cases, it can be caused by malignancy, even metastatic lesions from extra-abdominal neoplasia. Herein, we report a case of a 64-year-old female with a history of invasive ductal carcinoma of the breast treated by chemotherapy, surgery, radiotherapy and hormonotherapy, relapsing several years later as a bone and a pleura metastasis successfully cured by locoregional therapy and hormonal treatment. She presented with acute abdominal pain without signs of peritonitis. Abdominal computed tomodensitometry showed sign of appendicitis. Therefore, laparoscopic exploration and appendicectomy was performed. During surgery, multiple peritoneal nodules were found and harvested. Pathology showed metastatic nodules of invasive ductal breast carcinoma, including in the appendicular wall, concluding to peritoneal carcinomatosis. The postoperative course was uneventful, but the patient died 1 year later after refusing anticancer treatment.

Different responses to preoperative chemotherapy for invasive lobular and invasive ductal breast carcinoma

2003 ◽  
Vol 29 (4) ◽  
pp. 361-367 ◽  
Author(s):  
V.F. Cocquyt ◽  
P.N. Blondeel ◽  
H.T. Depypere ◽  
M.M. Praet ◽  
V.R. Schelfhout ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Preoperative Chemotherapy ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma

CA 15–3 Serum Levels in Patients with Ductal Breast Carcinoma: Relationship with Clinicopathological Parameters and Tumor Markers

2012 ◽  
Vol 27 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Angel González-Sistal ◽  
José Ignacio Arias ◽  
Álvaro Ruibal
Keyword(s):  
Breast Carcinoma ◽  
Tumor Markers ◽  
Cathepsin D ◽  
Hormone Receptors ◽  
Ductal Carcinoma ◽  
Serum Levels ◽  
S Phase ◽  
Phase Fraction ◽  
Clinicopathological Parameters ◽  
Ductal Breast Carcinoma

Introduction Cancer antigen 15–3 (CA 15–3) is the most widely used serum marker in diagnosing and monitoring breast cancer. The aim of this work was to analyze preoperative CA 15–3 serum levels in patients with ductal breast carcinoma in relation to 1) clinicopathological parameters, 2) hormone receptors, and 3) tissue-based tumor markers. Methods A group of 340 women with infiltrating ductal carcinoma of the breast who had undergone no prior treatment was studied. These women ranged in age between 27 and 83 years (mean age 61.5±9.9 years). Preoperative CA 15–3 serum levels were determined by an immunoradiometric method. Hormone receptors (estrogen, progesterone and androgen receptors), p53, bcl-2 and Ki67 were determined by different immunohistochemical methods. Epidermal growth factor receptor (EGFR) was analyzed in the cell membranes by radioligand assay whereas cathepsin D and pS2 were determined by immunoradiometric analysis. Tumor ploidy and S-phase fraction were studied by flow cytometry. Results CA 15–3 serum levels were higher in postmenopausal women (p=0.032), in patients with tumors exceeding 2 cm (p=0.003), lymph node involvement (p=0.026), distant metastases (M1) (p<0.0001), S-phase fraction <7% (p=0.015), EGFR <6 fmol/mg protein (p=0.025), and cathepsin D <50 pmol/mg protein (p=0.023). Conclusions Preoperative CA 15–3 serum levels were associated with cell proliferation determined by the S-phase fraction, the concentration of cathepsin D in the cytosol, and the EGFR concentration in the cell membrane.

scholarly journals Invasive ductal breast carcinoma

2010 ◽  
Author(s):  
Ayla Al Kabbani ◽  
Alexandra Stanislavsky
Keyword(s):  
Breast Carcinoma ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma

scholarly journals Depletion of nuclear SOX9 impairs differentiation & facilitates growth of invasive ductal breast carcinoma

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Geetika Chakravarty ◽  
Krystof Moroz ◽  
Michelle R Lacey ◽  
Nick M Makridakis ◽  
Krishna Agrawal ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma
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