MIRNA AS DIAGNOSTIC MARKERS OF ACUTE MYOCARDIAL INFARCTION AND HEART MUSCLE REMODELING

2019 ◽  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Muscle ◽  
Diagnostic Markers ◽  
Muscle Remodeling

scholarly journals Diagnostic markers for discriminating between acute aortic dissection and acute myocardial infarction during the pre-hospital phase: analysis of 3,195 cases

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
K Watanabe ◽  
H Yoshino ◽  
T Takahashi ◽  
M Usui ◽  
K Akutsu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Back Pain ◽  
Chest Pain ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Diagnostic Markers ◽  
Network Database ◽  
History Of ◽  
First Contact

Abstract   Both acute aortic dissection (AAD) and acute myocardial infarction (AMI) present with chest pain and are life-threatening diseases that require early diagnosis and treatment for better clinical outcome. However, two critical diseases in the very acute phase are sometimes difficult to differentiate, especially prior to arrival at the hospital for urgent diagnosis and selection of specific treatment. The aim of our study was to clarify the diagnostic markers acquired from the information gathered from medical history taking and physical examination for discriminating AAD from AMI by using data from the Tokyo Cardiovascular Care Unit (CCU) Network database. We examined the clinical features and laboratory data of patients with AAD and AMI who were admitted to the hospital in Tokyo between January 2013 and December 2015 by using the Tokyo CCU Network database. The Tokyo CCU Network consists of >60 hospitals that fulfil certain clinical criteria and receive patients from ambulance units coordinated by the Tokyo Fire Department. Of 15,061 patients diagnosed as having AAD and AMI, 3,195 with chest pain within 2 hours after symptom onset (537 AAD and 2,658 AMI) were examined. The patients with out-of-hospital cardiac arrest were excluded. We compared the clinical data of the patients with chest pain who were diagnosed as having AAD and AMI. The following indicators were more frequent or had higher values among those with AAD: female sex (38% vs. 20%, P<0.001), systolic blood pressures (SBPs) at the time of first contact by the emergency crew (142 mmHg vs. 127 mmHg), back pain in addition to chest pain (54% vs. 5%, P<0.001), history of hypertension (73% vs. 58%, P<0.001), SBP ≥150 mmHg (39% vs. 22%, P<0.001), back pain combined with SBP ≥150 mmHg (23% vs. 0.8%, P<0.001), and back pain with SBP <90 mmHg (4.5% vs. 0.1%, P<0.001). The following data were less frequently observed among those with AAD: diabetes mellitus (7% vs. 28%, P<0.001), dyslipidaemia (17% vs. 42%, P<0.001), and history of smoking (48% vs. 61%, P<0.001). The multivariate regression analysis suggested that back pain with SBP ≥150 mmHg (odds ratio [OR] 47; 95% confidence interval [CI] 28–77; P<0.001), back pain with SBP <90 mmHg (OR 68, 95% CI 16–297, P<0.001), and history of smoking (OR 0.49, 95% CI 0.38–0.63, P<0.001) were the independent markers of AAD. The sensitivity and specificity of back pain with SBPs of ≥150 mmHg and back pain with SBPs <90 mmHg for detecting AAD were 23% and 99%, and 4% and 99%, respectively. In patients with chest pain suspicious of AAD and AMI, “back pain accompanied by chest pain with SBP ≥150 mmHg” or “back pain accompanied by chest pain with SBP <90 mmH” is a reliable diagnostic marker of AAD with high specificity, although the sensitivity was low. The two SBP values with back pain are markers that may be useful for the ambulance crew at their first contact with patients with chest pain. Funding Acknowledgement Type of funding source: None

Importance of the source of hyaluronidase preparations in determining protective effect on ischemic heart muscle in acute myocardial infarction

1981 ◽  
Vol 102 (3) ◽  
pp. 324-329 ◽  
Author(s):  
Tsutomu Iwasaki ◽  
Lair G.T. Ribeiro ◽  
Duarte B. Faria ◽  
Wai-Man Cheung ◽  
Peter R. Maroko
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Protective Effect ◽  
Heart Muscle ◽  
Ischemic Heart

scholarly journals GAMBARAN KADAR HEMATOKRIT DAN HEMOGLOBIN PADA KEJADIAN INFARK MIOKARD AKUT (IMA) DI RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI - AGUSTUS 2014

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Fitri Jumalang ◽  
Linda W. A. Rotty ◽  
Agnes L. Panda
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cell Death ◽  
Heart Muscle ◽  
Heart Attack ◽  
Descriptive Study ◽  
Developed Countries ◽  
Heart Muscle Cell ◽  
Common Diagnosis ◽  
Age And Sex

Abstract: Acute myocardial infarction (AMI) or better known as a heart attack is a condition where the blood supply to a part of the heart stops so that the heart muscle cell death. Acute myocardial infarction is one of the most common diagnosis in developed countries. The rate of initial mortality (30 days) at the IMA is 30% with more than half of the deaths occur before the patient reaches the hospital. Methods - This research is a retrospective descriptive study. Samples were adult patients suffering from acute myocardial infarction who were treated in RSUP Prof. Dr R. D. Kandou. Results - Overview hematocrit and hemoglobin levels in the incidence of acute myocardial infarction in the department of Prof. Dr. RD Kandou Manado period January - August 2014 hemodilution patients get as many as 19 people (61.3%) and patients with normal hematocrit many as 12 people (38.7% ). In addition, for an overview of hemoglobin by age and sex obtained anemia patients by 5 people (16.1%) and patients with normal hemoglobin many as 26 people (83.9%). Conclusions - AMI patients in RSUP Prof. Dr RD Kandou Manado period January-August 2014 are subjected to low hematocrit (hemodilution) and normal hemoglobin.Keywords: acute myocardial infarction, hematocrit, hemoglobinAbstrak: Infark miokard akut (IMA) atau yang lebih dikenal dengan serangan jantung adalah suatu keadaan dimana suplai darah pada suatu bagian jantung terhenti sehingga sel otot jantung mengalami kematian. Infark miokard akut merupakan salah satu diagnosis rawat inap tersering di negara maju. Laju mortalitas awal (30 hari) pada IMA adalah 30% dengan lebih dari separuh kematian terjadi sebelum pasien mencapai Rumah Sakit. Metode - Penelitian ini merupakan penelitian deskriptif retrospektif. Sampel penelitian ini adalah penderita dewasa yang menderita infark miokard akut yang dirawat di RSUP Prof. Dr. R. D. Kandou. Hasil - Gambaran kadar hematokrit dan hemoglobin pada kejadian infark miokard akut di RSUP Prof DR RD Kandou Manado periode januari – agustus 2014 didapatkan pasien hemodilusi sebanyak 19 orang (61,3%) dan pasien hematokrit normal sebanyak 12 orang (38,7%). Selain itu, untuk gambaran hemoglobin berdasarkan umur dan jenis kelamin didapatkan pasien yang anemia sebanyak 5 orang (16,1%) dan pasien hemoglobin normal sebanyak 26 orang (83,9%). Simpulan - Pasien IMA di RSUP Prof. Dr. R. D. Kandou Manado periode januari-agustus 2014 sebagian besar mengalami hematokrit rendah (hemodilusi) dan hemoglobin normal.Kata kunci: infark miokard akut, hematokrit, hemoglobin

scholarly journals Main Aspects of Biochemistry, Physiology of Cardiac Troponins

2020 ◽  
Vol 6 (5) ◽  
pp. 105-112 ◽  
Author(s):  
A. Chaulin ◽  
Yu. Grigoryeva
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Cardiovascular Diseases ◽  
Heart Muscle ◽  
Troponin I ◽  
Contractile Function ◽  
Structure And Functions ◽  
Cardiac Troponins

Cardiac troponins (troponin I, T, and C) play an important role in the regulation of contractile function of the heart muscle. Mutations in cardiac troponins are associated with the development of various types of cardiomyopathies, which lead to heart failure and death. The determination of the concentration of cardiac troponins in the blood is used in the diagnosis of some cardiovascular diseases, including acute myocardial infarction, myocarditis, heart failure. This review summarizes the available data on the structure and functions of cardiac troponins, their role in the regulation of myocardial contractions and clinical application.

scholarly journals Diagnostic markers of acute myocardial infarction

2015 ◽  
Vol 3 (6) ◽  
pp. 743-748 ◽  
Author(s):  
SABESAN MYTHILI ◽  
NARASIMHAN MALATHI
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Diagnostic Markers
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