scholarly journals Proton (1H) MR Spectroscopy of the Breast at 3.0T: Detectability of the Choline Peak of Breast Cancer in Comparison with a 1.5T Imager

2010 ◽  
Vol 22 (4) ◽  
pp. 221-227
Author(s):  
Makoto SAIKI ◽  
Masanori HIROSE ◽  
Jumpei SUYAMA ◽  
Yoshimitsu OHGIYA ◽  
Takehiko GOKAN
Keyword(s):  
Breast Cancer ◽  
Mr Spectroscopy ◽  
1H Mr Spectroscopy ◽  
Choline Peak

The key role of correlation between MR spectroscopy choline peak and calcium sensing receptor for breast cancer: Diagnosis by a 3T MR scanner.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e22132-e22132
Author(s):  
Gabriella Baio ◽  
Francesca Valdora ◽  
Daniele Pace ◽  
Sandra Salvi ◽  
Nicolo Villosio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mr Spectroscopy ◽  
Breast Lesions ◽  
Breast Cancers ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Malignant Lesions ◽  
High Level ◽  
3T Mr ◽  
Choline Peak

e22132 Background: The Ca2+-sensing receptor (CaSR) regulates the Ca2+ signaling and its expression is present in both normal and malignant breast tissues. Recently, we demonstrated in a pre-clinical setting the CaSR expression in breast cancer mouse model by manganese enhanced MRI (Baio G et al. Eur Rad 2011). Alteration in choline phospholipid metabolism as detected by MRI, is a common feature of breast and many other cancer cells or tumors. Since CaSR-ChoK signaling plays an important role in breast cancer, we compared the MRS (MR spectroscopy) choline peak by a 3T MR scanner between calcium sensing receptor positive and negative breast cancers. Methods: Breast MRI of 16 consecutive patients with breast lesions were performed by a 3T MR and MRS findings were defined as positive by the visual inspection for the presence or the absence of choline peak. MRS imaging were compared with histologic findings and the pattern of CaSR by immunohistochemistry. The immunohistochemical results were qualitatively classified according to intensity and pattern of the staining, using a 6-point scale to score the intensity of the CaSR expression (0, absent; 5, intense, widespread expression). Results: A choline peak was present in 10 of 15 malignant lesions and the CaSR expression was between 3 to 5 score at immunohistochemestry analysis (p<.0006). In 4 of 15 malignant lesions the choline peak was absent or not consistent at the visual analysis with a CaSR patterns of 1-2. In one benign lesion (papillary hyperplasia), the choline peak was consistent and the CaSR pattern was with score 3. Conclusions: In this study we evaluated if MRS presence or absence of choline peak well correlated with CaSR positive and negative breast cancers. We observed a choline peak with an high level expression of CaSR (score 3-5) in 67% of the breast lesions, while in 27% of the lesions the choline peak was absent with a low CaSR expression (score 1-2). These preliminary results support the hypothesis that CaSR represents an important role in the production of choline in breast cancer, determining an increase of his production when CaSR is expressed at high level and implicating and absence of choline peak when CaSR is not expressed.

Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study

2015 ◽  
Vol 17 (4) ◽  
pp. 548-556 ◽  
Author(s):  
Gabriella Baio ◽  
Giuseppe Rescinito ◽  
Francesca Rosa ◽  
Daniele Pace ◽  
Simona Boccardo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Study ◽  
Mr Spectroscopy ◽  
Receptor Expression ◽  
Expression Level ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Choline Peak

1H MR spectroscopy monitoring of changes in choline peak area and line shape after Gd-contrast administration

1998 ◽  
Vol 16 (10) ◽  
pp. 1273-1280 ◽  
Author(s):  
Paul E Sijens ◽  
Matthijs Oudkerk ◽  
Pieter van Dijk ◽  
Peter C Levendag ◽  
Charles J Vecht
Keyword(s):  
Line Shape ◽  
Mr Spectroscopy ◽  
Contrast Administration ◽  
1H Mr Spectroscopy ◽  
Choline Peak

scholarly journals 1H MR Spectroscopy of Fine-Needle Aspiration Biopsy Specimens for the Discrimination of Breast Cancer

2020 ◽  
Vol 2 (6) ◽  
pp. e200033
Author(s):  
Richard A. Komoroski ◽  
Jing-Huei Lee ◽  
Jeffrey A. Welge ◽  
Jonathan A. Dudley ◽  
Wen-Jang Chu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fine Needle Aspiration ◽  
Mr Spectroscopy ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
1H Mr Spectroscopy ◽  
Biopsy Specimens ◽  
Needle Aspiration Biopsy

scholarly journals Diffusion-weighted imaging or MR spectroscopy: Which to use for the assessment of the response to chemotherapy in breast cancer patients?

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Sahar Mansour ◽  
Ashraf Selim ◽  
Loay Kassam ◽  
Mirna Adel ◽  
Aya Bassam Hashem
Keyword(s):  
Breast Cancer ◽  
Complete Remission ◽  
Cancer Patients ◽  
Mr Spectroscopy ◽  
Residual Disease ◽  
Breast Cancer Patients ◽  
Adc Value ◽  
Dce Mri ◽  
Pathological Complete Remission ◽  
Choline Peak

Abstract Background Diffusion-weighted MRI (DWI) and MR spectroscopy (MRS) both are noninvasive MR sequences that could be used as a reliable tool to assess the functional behavior of the breast cancer. The aim of the study was to assess the value of DWI and MRS in predicting the early response to neo-adjuvant chemotherapy (NAC) and absence of residual disease after treatment. Results One hundred thirty-three patients diagnosed with breast cancer and scheduled for NAC were enrolled in this study. All lesions were subjected to qualitative and quantitative analysis of DCE-MRI, DWI and MRS, where the lesions size, kinetic parameters, ADC values and MRS choline peak were recorded before the start of NAC and after completion of chemotherapy. The results of each MRI modality were correlated with the findings that were found at the pathology report of the complete surgical specimen. The sensitivity and specificity of the MR modalities to predict pathological complete remission post-NAC were 73.68% and 83.33%, respectively, using the kinetic curve pattern, 78.95% and 83.33%, respectively, using the ADC value and finally 78.95% and 91.67%, respectively, using the MRS choline peak. Similar sensitivity (89.47%) to predict pathological complete remission was presented by the ADC value and the MRS choline peak together when compared to the ADC value and dynamic curve patterns. Conclusion DWI and MRS are valuable MRI techniques and their accuracy in detecting residual disease is almost similar to that of DCE MRI. The inclusion of these sequences in the imaging protocol of NAC candidates improve monitoring of the response to treatment and allow early distinction between complete, partial and non-responders' cases in breast cancer patients.

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