Total choline quantification measured by 1H MR spectroscopy as early predictor of response after neoadjuvant treatment for locally advanced breast cancer: The impact of immunohistochemical status

2018 ◽  
Vol 48 (4) ◽  
pp. 982-993 ◽  
Author(s):  
Stylianos Drisis ◽  
Patrick Flamen ◽  
Michael Ignatiadis ◽  
Thierry Metens ◽  
Shih-Li Chao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Mr Spectroscopy ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Neoadjuvant Treatment ◽  
Advanced Breast ◽  
1H Mr Spectroscopy ◽  
The Impact ◽  
Early Predictor

scholarly journals Neoadjuvant radiotherapy in the approach of locally advanced breast cancer

ESMO Open ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. e000640 ◽  
Author(s):  
Cláudia Sousa ◽  
Mafalda Cruz ◽  
Ana Neto ◽  
Kayla Pereira ◽  
Marta Peixoto ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Progression Free Survival ◽  
Complete Response ◽  
Intrinsic Subtype ◽  
Advanced Breast ◽  
Neoadjuvant Radiotherapy ◽  
The Impact

BackgroundApproximately 4% of European patients are diagnosed with locally advanced breast cancer (LABC), a clinical condition commonly associated with poorer prognosis. Systemic therapy is the recommended initial treatment and when inoperability criteria prevails, radiotherapy (RT) should be used for tumour downstaging. This study intends to evaluate the impact of neoadjuvant radiotherapy (NART) in the treatment of inoperable LABC.MethodsA retrospective study of female patients, submitted to the NART between January 2014 and December 2018 at our institution. The evaluation of pathological response (pR) was made based on Pinder criteria. Primary endpoint: pR. Secondary endpoints: overall survival (OS) and progression-free survival (PFS). OS and PFS were calculated using the Kaplan-Meier method. Differences between groups were compared using Student’s t-test, ANOVA (Analysis of variance) and χ2 test. The statistical analyses were performed using Stata (V.13).ResultsA total of 76 patients were included, 18% with breast complete response. The 5 years OS was 54% and PFS was 61%. Subgroup analysis showed that pR >90% is correlated with a better OS (p=0.004). Basal-like intrinsic subtype is correlated with worse OS and PFS (p<0.05). No relation was found between response and age, intrinsic subtype, treatment performed and clinical T stage.ConclusionOur study confirms that NART is an effective downsizing treatment in inoperable LABC, allowing for a surgical resection regardless of the systemic treatment performed. Response to NART is independent of the intrinsic subtype and pR >90% is correlated with a better OS. Prospective studies to explore predictive response biomarkers are necessary in order to improve patient selection and optimisation of the treatment.

Prolonged neoadjuvant treatment plus GM-CSF in locally advanced breast cancer: clinical and biological concepts

2004 ◽  
Vol 6 (3) ◽  
pp. 130-139
Author(s):  
Paula Raffin Pohlmann ◽  
Laura Suchil Bernal ◽  
Adolfo Fuentes Alburo ◽  
Jan Buter ◽  
Dolores Gallardo Rincón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Neoadjuvant Treatment ◽  
Advanced Breast ◽  
Gm Csf ◽  
Biological Concepts

Epirubicin and Docetaxel as Neoadjuvant Treatment of Locally Advanced Breast Cancer: A Phase II Study

2010 ◽  
Vol 96 (2) ◽  
pp. 229-233 ◽  
Author(s):  
Davide Lombardi ◽  
Simona Scalone ◽  
Diana Crivellari ◽  
Maria Donatella Magri ◽  
Nicoletta La Mura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Phase Ii ◽  
Phase Ii Study ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Neoadjuvant Treatment ◽  
Advanced Breast
Sign in / Sign up

Export Citation Format

Share Document