scholarly journals Predicting Articular Cartilage Constituent Material Properties Following In Vitro Growth Using a Proteoglycan-Collagen Mixture Model

2011 ◽  
Author(s):  
Michael Stender
Keyword(s):  
Articular Cartilage ◽  
Mixture Model ◽  
Material Properties ◽  
In Vitro Growth ◽  
Constituent Material

Regulation of Articular Cartilage Volumetric and Compressive Properties by Sequential Application of IGF-1 and TGF-β1 During In Vitro Growth

2010 ◽  
Author(s):  
Kristin J. Dills ◽  
Jennifer R. Van Donk ◽  
Gregory M. Williams ◽  
Stephanie A. Smith ◽  
Albert C. Chen ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
In Vitro Growth ◽  
Compressive Properties ◽  
Low Friction ◽  
Volumetric Growth ◽  
Bearing Material ◽  
Mechanical Integrity ◽  
Naturally Occurring ◽  
Tgf Β1

Articular cartilage (AC) is a load bearing material that provides a low friction wear resistant interface in synovial joints. Naturally-occurring and stimulated intrinsic repair of damaged AC is challenging [1]. Thus, there is a need to guide the formation of tissue of specific size and mechanical properties for AC repair. Previous studies [2,3] with immature cartilage have shown that culture with medium containing TGF-β1 results in enhanced mechanical integrity while culture with IGF-1 results in diminished mechanical integrity. Conversely, culture with medium containing IGF-1 results in substantial volumetric growth while culture with TGF-β 1 results in little or no volumetric growth.

scholarly journals Articular cartilage mechanical and biochemical property relations before and after in vitro growth

2007 ◽  
Vol 40 (16) ◽  
pp. 3607-3614 ◽  
Author(s):  
Timothy Ficklin ◽  
Gregory Thomas ◽  
James C. Barthel ◽  
Anna Asanbaeva ◽  
Eugene J. Thonar ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Biochemical Property ◽  
In Vitro Growth ◽  
Property Relations ◽  
Before And After

scholarly journals In vitro growth factor-induced bio engineering of mature articular cartilage

Biomaterials ◽  
2013 ◽  
Vol 34 (5) ◽  
pp. 1478-1487 ◽  
Author(s):  
Ilyas M. Khan ◽  
Lewis Francis ◽  
Peter S. Theobald ◽  
Stefano Perni ◽  
Robert D. Young ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Growth Factor ◽  
In Vitro Growth ◽  
Bio Engineering

Effect of in Vivo Oxidized Cellulose on in Vitro Growth of Human Respiratory Mucosa and Sub-mucosa During Endoscopic Skull Base Approaches

2016 ◽  
Vol 77 (S 01) ◽  
Author(s):  
Ezequiel Goldschmidt ◽  
Jorge Rasmussen ◽  
Joseph Chabot ◽  
Monica Loressi ◽  
Marcelo Ielpi ◽  
...  
Keyword(s):  
Skull Base ◽  
Oxidized Cellulose ◽  
In Vitro Growth ◽  
Respiratory Mucosa

Cytocompatibility and Material Properties of Poly-carbonate Urethane/Carbon Nanofiber Composites for Neural Applications

2003 ◽  
Vol 774 ◽  
Author(s):  
Janice L. McKenzie ◽  
Michael C. Waid ◽  
Riyi Shi ◽  
Thomas J. Webster
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanofibers ◽  
Material Properties ◽  
Carbon Nanofiber ◽  
Scar Tissue ◽  
Tissue Response ◽  
Positive Interactions ◽  
Weight Percentage ◽  
Poly Carbonate

AbstractCarbon nanofibers possess excellent conductivity properties, which may be beneficial in the design of more effective neural prostheses, however, limited evidence on their cytocompatibility properties exists. The objective of the present in vitro study was to determine cytocompatibility and material properties of formulations containing carbon nanofibers to predict the gliotic scar tissue response. Poly-carbonate urethane was combined with carbon nanofibers in varying weight percentages to provide a supportive matrix with beneficial bulk electrical and mechanical properties. The substrates were tested for mechanical properties and conductivity. Astrocytes (glial scar tissue-forming cells) were seeded onto the substrates for adhesion. Results provided the first evidence that astrocytes preferentially adhered to the composite material that contained the lowest weight percentage of carbon nanofibers. Positive interactions with neurons, and, at the same time, limited astrocyte functions leading to decreased gliotic scar tissue formation are essential for increased neuronal implant efficacy.

Sign in / Sign up

Export Citation Format

Share Document