scholarly journals Intestinal Calcium Absorption in Spontaneously Hypertensive Rats

1994 ◽  
Vol 35 (4) ◽  
pp. 532-532 ◽  
Author(s):  
Satoshi Fukuda ◽  
Haruzo Iida ◽  
Satoru Tsuchikura ◽  
Yasuo Nara ◽  
Katsumi Ikeda ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Calcium Absorption ◽  
Intestinal Calcium Absorption ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Calcium absorption and bone utilization in spontaneously hypertensive rats fed on native and heat-damaged casein and soya-bean protein

1994 ◽  
Vol 71 (4) ◽  
pp. 583-603 ◽  
Author(s):  
Yvonne V. Yuan ◽  
David D. Kitts
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Calcium Absorption ◽  
Soya Bean ◽  
Whole Body ◽  
Hypertensive Rats ◽  
Balance Study ◽  
Spontaneously Hypertensive ◽  
Physical Measurements ◽  
Protein Diets ◽  
Bean Protein

The effects of dietary protein on Ca bioavailability and utilization in bone were examined in male spontaneously hypertensive rats (SHR) fed on diets containing either casein (200 g/kg (control), 60 g/kg or heat-damaged (HD) 200 g/kg) or soya-bean protein isolate (200 g/kg (control), 60 g/kg, or HD 200 g/kg). Casein was heat-damaged to limit caseinophosphopeptide (CPP) production in order to evaluate casein enhancement of Ca bioavailability. All diets contained an adequate level of Ca (5 g/kg). A 24 h mineral balance study was performed when animals were 10 weeks old, followed by measurement of in situ paracellular Ca disappearance, femur mineralization and biomechanics at 14 weeks of age. Digestibility of soya-bean and both HD proteins estimated in vitro was reduced compared with native casein. Animals fed on HD and 60 g/kg protein diets exhibited decreased (P < 0.05) body weight gain, dry matter intake and feed efficiency compared with controls. The ileal disappearance of 45Ca was lower (P < 0.05) in animals fed on HD casein and all the soya-bean protein diets. Ca balance was not strongly affected by dietary treatments. A significant (P < 0.05) interaction between protein source and reduced protein intake was observed for femur calcification and physical measurements. Femur bending failure energy and biomechanical force measurements were reduced (P < 0.05) in HD and 60 g/kg casein and soya-bean protein fed animals. These findings suggest that whole-body Ca homeostatic mechanisms were involved in compensating for reduced Ca bioavailability and retention from casein diets modified to reduce protein digestibility and CPP production.

Ca fluxes across duodenum and colon of spontaneously hypertensive rats: effect of 1,25(OH)2D3

1986 ◽  
Vol 251 (2) ◽  
pp. F278-F282 ◽  
Author(s):  
U. Gafter ◽  
S. Kathpalia ◽  
D. Zikos ◽  
K. Lau
Keyword(s):  
Calcium Transport ◽  
Spontaneously Hypertensive Rats ◽  
Calcium Absorption ◽  
Short Circuit ◽  
Short Circuit Current ◽  
Calcium Flux ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto

Calcium absorption by spontaneously hypertensive rats (SHR) was variably reported to be different from normotensive Wistar-Kyoto (WKY) controls. Furthermore, blunted responsiveness to the intestinal effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] has also been postulated. To evaluate this hypothesis, calcium fluxes were measured by the Ussing technique across duodenum and descending colon with or without prior 1,25(OH)2D3 treatment. Duodenal mucosal-to-serosal calcium flux (Jm----s) (44.9 vs. 52.4 nmol X cm-2 X h-1), serosal-to-mucosal flux (Js----m) (25.6 vs. 28.4 nmol X cm-2 X h-1), and net flux (Jnet) were comparable. 1,25(OH)2D3 increased duodenal Jm----s in both SHR and WKY groups (95.2 and 86.8 nmol X cm-2 X h-1). Js----m was lower in SHR (26.1 vs. 35.6 nmol X cm-2 X h-1, P less than 0.01), although the tendency for a higher Jnet in SHR (68.6 vs. 51.2 nmoles X cm-2 X h-1) was statistically insignificant. Short-circuit current was higher in the colon of SHR, both before and after 1,25(OH)2D3, suggesting increased sodium transport. Basal colonic Jnet was virtually zero in both groups but comparably increased by 1,25(OH)2D3 because of stimulation in only Jm----s. Prevention of hypertension by hydralazine since the 4th wk of age did not alter the findings compared with the hypertensive SHR, suggesting calcium transport rates were unaffected by hypertension. These data indicate that in vitro, duodenal, and colonic active calcium transport by the SHR is similar to WKY. Their normal responses to 1,25(OH)2D3 do not support the hypothesis of intestinal resistance.

Biomembrane Characteristics in Stroke-prone Spontaneously Hypertensive Rats (SHRSP)

1978 ◽  
Vol 19 (4) ◽  
pp. 597-598 ◽  
Author(s):  
Yukio YAMORI ◽  
Yasuo NARA ◽  
Ryoichi HORIE ◽  
Michiya OHTAKA ◽  
Kiyoe OHTA ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Enhanced Emotional Response in Stroke-Prone Spontaneously Hypertensive Rats

1991 ◽  
Vol 32 (4) ◽  
pp. 579-579 ◽  
Author(s):  
Sawako Kobayashi ◽  
Tomoyo Tanaka ◽  
Tetsuo Akai ◽  
Motonori Yamaguchi ◽  
Hiroshi Ogawa ◽  
...  
Keyword(s):  
Emotional Response ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
Sign in / Sign up

Export Citation Format

Share Document