scholarly journals Specific Binding Sites for Endothelins in the Central Nervous System

1991 ◽  
Vol 32 (4) ◽  
pp. 575-575
Author(s):  
Masami Niwa ◽  
Meiko Fujimoto ◽  
Yasufumi Kataoka ◽  
Kohtaro Taniyama
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Binding Sites ◽  
Specific Binding ◽  
Specific Binding Sites ◽  
The Central Nervous System

Heterogeneity of high affinity nitrobenzylthioinosine binding sites in mammalian cortical membranes: multiple forms of central nervous system nucleoside transporters?

1984 ◽  
Vol 62 (8) ◽  
pp. 961-963 ◽  
Author(s):  
James R. Hammond ◽  
Alexander S. Clanachan
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Guinea Pig ◽  
Binding Sites ◽  
Specific Binding ◽  
Mammalian Species ◽  
Nucleoside Transport ◽  
Single Class ◽  
The Central Nervous System ◽  
Cortical Membranes

Specific binding of [3H]nitrobenzylthioinosine to cortical membranes from several mammalian species was investigated. Rat, mouse, guinea pig, and dog membranes contained an apparent single class of binding sites; there was, however, a marked species-dependent variation in their affinity for [3H]nitrobenzylthioinosine. Rabbit cortical membranes contained two classes of binding sites and the high and low affinity components were similar to those found in guinea pig and dog cortical membranes, respectively. The [3H]nkrobenzylthioinosine binding sites in rat and the low affinity sites in rabbit were atypical in that they exhibited a low affinity for dipyridamole. It is proposed that these latter sites may represent a form of the central nervous system nucleoside transport system which is less susceptible to inhibition by dipyridamole.

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