scholarly journals Is Serum Uric Acid Independently Associated With Left Ventricular Mass Index, Ejection Fraction, and B-Type Natriuretic Peptide Among Female and Male Cardiac Patients?

2017 ◽  
Vol 58 (4) ◽  
pp. 562-569 ◽  
Author(s):  
Yohei Yamauchi ◽  
Shu-ichi Fujita ◽  
Kensaku Shibata ◽  
Hideaki Morita ◽  
Takahide Ito ◽  
...  
Keyword(s):  
Uric Acid ◽  
Ejection Fraction ◽  
Left Ventricular Mass ◽  
Serum Uric Acid ◽  
Natriuretic Peptide ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Cardiac Patients ◽  
Ventricular Mass Index ◽  
Ventricular Mass

scholarly journals Serum Uric Acid Is Associated With the Left Ventricular Mass Index in Males of a General Population

2014 ◽  
Vol 55 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Ayako Yoshimura ◽  
Hisashi Adachi ◽  
Yuji Hirai ◽  
Mika Enomoto ◽  
Ako Fukami ◽  
...  
Keyword(s):  
Uric Acid ◽  
General Population ◽  
Left Ventricular Mass ◽  
Serum Uric Acid ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Ventricular Mass

scholarly journals ARTERIAL HYPERTENSION ASSOCIATED WITH HYPERURICEMIA: FEATURES OF HEART DAMAGE

2020 ◽  
Vol 73 (5) ◽  
pp. 943-946
Author(s):  
Olha M. Chernatska ◽  
Liudmyla N. Prystupa ◽  
Hanna A. Fadieieva ◽  
Alina V. Liashenko ◽  
Yuliia O. Smiianova
Keyword(s):  
Uric Acid ◽  
Left Ventricular Hypertrophy ◽  
Arterial Hypertension ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Serum Uric Acid Level ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Ventricular Mass

The aim is the analysis of hyperuricemia influence on the heart features in patients with arterial hypertension. Materials and methods: We include 75 patients with arterial hypertension which were divided in two groups according to the level of uric acid in the blood, 30 practically healthy people. Patients from the I group (n = 40) had arterial hypertension and coexistent hyperuricemia; ІІ (n = 35) – arterial hypertension. Left ventricular mass index was determined for left ventricular hypertrophy confirmation. We used clinical, anthropometric, biochemical, instrumental, statistical method. Serum uric acid level was observed by the reaction with uricase. Left ventricular mass index was calculated as left ventricular mass to body surface area ratio. The results were analyzed statistically by SPSS 21 and Graphpad. Results: Left ventricular mass index was significantly higher (р = 0,0498) in patients from the І group (109,7 ± 3,21) g/m2 comparable with the ІІ (97,6 ± 5,35) g/m2 and increased in proportion to the biggest level of uric acid (r = 0,31; p = 0,04) in patients with arterial hypertension and hyperuricemia. Conclusions: Concentric and excentric left ventricular hypertrophy, increased left ventricular mass index proportionally to uric acid levels (r = 0,31; p = 0,04) is the confirmation of important role of hyperuricemia in the left ventricular hypertrophy development in patients with arterial hypertension.

scholarly journals Echocardiographic abnormalities in non-moderate drinking of alcohol for prolonged duration

1970 ◽  
Vol 6 (1) ◽  
pp. 18-28
Author(s):  
MP Gautam ◽  
U Ghimire Gautam ◽  
S Dwivedi ◽  
S Rijal
Keyword(s):  
Ejection Fraction ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Moderate Drinking ◽  
Ventricular Mass Index ◽  
Total Lifetime ◽  
Ventricular Mass

Background: Alcohol drinking is cardio-protective; however its beneficial and harmful effects depend on the amount consumed. This work is designed to assess the impact of prolonged non-moderate drinking in left ventricular mass index and left ventricular ejection fraction and the correlation of their severity with total lifetime intake amount. Materials and methods: Fifty non-moderate drinkers (>25 g/day) for last 10 years and 50 non-drinker-volunteers were selected. Detail echocardiographic assessment was done and findings were compared and severity was correlated with lifetime amount. Results: Mean daily intake, duration and lifetime intake amount of alcohol were 64.1 g, 21.9 years and 501.9 Kg respectively. The mean ejection fraction and left ventricular mass index were 47.2% and 105.3 g/m2. There was significant difference when compared with controls. Eighty-two percent drinking subjects had abnormal echo, most common were regurgitations (52%), diastolic dysfunction (46%), raised ventricular mass (44%), systolic dysfunction (40%), and dilated left atrium and ventricle (38%). Thirty-four percent of subjects had echo features consistent with dilated cardiomyopathy. Palpitation and dyspnea in combination were the only symptoms associated with severity of echo changes. There was strong negative correlation of lifetime intake amount with ejection fraction (r = -0.91, p<0.001); however its relationship with ventricular mass index was not statistically significant (r = 0.23, p>0.05). Conclusions: Prolonged non-moderate drinking causes significant echocardiographic abnormalities mainly systolic dysfunction and increased left ventricular mass index. The total lifetime and daily amount of alcohol are well correlated with systolic dysfunction; however their relationships with the left ventricular mass index were non-conclusive. Key words: Alcohol; left ventricular mass; cardiomyopathy DOI: 10.3126/jcmsn.v6i1.3598 Journal of College of Medical Sciences-Nepal, 2010, Vol. 6, No. 1, 18-28

scholarly journals Serum Uric Acid and Left Ventricular Mass in Essential Hypertension

2020 ◽  
Vol 7 ◽  
Author(s):  
Valeria Visco ◽  
Antonietta Valeria Pascale ◽  
Nicola Virtuoso ◽  
Felice Mongiello ◽  
Federico Cinque ◽  
...  
Keyword(s):  
Uric Acid ◽  
Left Ventricular Mass ◽  
Serum Uric Acid ◽  
Kidney Function ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
University Hospital ◽  
Ventricular Mass ◽  
Severe Chronic Kidney Disease ◽  
Independent Association

Serum uric acid (sUA) has been associated with cardiovascular risk. Although the recent mechanistic hypothesis poses the basis for the association between sUA and left ventricular mass index (LVMi), the issue remains poorly investigated in a clinical setup. Through a retrospective analysis of the database of the departmental Hypertension Clinic of University Hospital of Salerno Medical School, we identified 177 essential hypertensives (age 60.3 ± 13.3 years; 85 men), free from uric acid-modulating medications and severe chronic kidney disease, and whose sUA values, anthropometric, clinical, and echocardiographic data were available. In the studied cohort, the average duration of hypertension was 8.4 ± 7.1 years. LVMi associated with classical determinants, such as age, blood pressure, and kidney function, although after multivariate correction, only age remained significant. Also, sUA correlated positively with LVMi, as well as body size, metabolism, and kidney function. In a multivariate analysis, sUA confirmed the independent association with LVMi. Also, levels of sUA &gt;5.6 mg/dl are associated with larger cardiac size. We confirmed our data in a replicate analysis performed in a larger population (1,379 hypertensives) from an independent clinic. Our results demonstrate that sUA increases with LVMi, and a cutoff of 5.6 mg/dl predict larger LV sizes. Our data suggest that hyperuricemia might help to stratify the risk of larger cardiac size in hypertensives.

Effect of Therapy on Left Ventricular Function in Hypertension

1980 ◽  
Vol 59 (s6) ◽  
pp. 435s-439s ◽  
Author(s):  
I. Khatri ◽  
J. Gottdiener ◽  
A. Notargiacomo ◽  
E. Freis
Keyword(s):  
Blood Pressure ◽  
Ejection Fraction ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Blood Pressure Reduction ◽  
Control Level ◽  
Left Ventricular ◽  
Temporary Increase ◽  
Ventricular Mass Index ◽  
Ventricular Mass

1. Twelve untreated hypertensive patients whose blood pressure was 171.8 ± 5.5 mmHg systolic and 119.7 ± 3.4 mmHg diastolic (mean ± sem) were treated aggressively with diuretics plus other antihypertensive agents. Echocardiograms were performed before, and 2 weeks, 3 months and 6 months after therapy. Blood pressures were lowered to an average of 142/98 mmHg over the 6 month period. 2. Mean velocity of circumferential fibre shortening rose from 1.1 ± 0.09 to 1.3 ± 0.06 diameters/s at 2 weeks and remained elevated at the end of 3 months (1.3 ± 0.03 diameters/s) (P&lt;0.025), but returned to the control level in 6 months. Similarly, ejection fraction increased significantly during the same period from a control value of 65.1 ± 4.4 to 73.4 ± 1.8% (P&lt;0.025) and persisted in this range at 3 months. At 6 months the ejection fraction had returned to pretreatment levels. There were significant reductions in left ventricular end-systolic and end-diastolic dimensions. Left ventricular mass index decreased from 182.3 ± 18.3 to 163.8 ± 12.4 g/m2 after 6 months of therapy. 3. These results indicate that in the early stages of blood pressure reduction there is a temporary increase in ejection phase indices, probably related to afterload reduction. The reduction in the left ventricular mass index suggests that increased cardiac muscle mass due to elevated blood pressure may be partially reversible after long-term reduction in blood pressure.

scholarly journals Uric Acid, Left Ventricular Mass Index, and Risk of Cardiovascular Disease in Essential Hypertension

Hypertension ◽  
2006 ◽  
Vol 47 (2) ◽  
pp. 195-202 ◽  
Author(s):  
Yoshio Iwashima ◽  
Takeshi Horio ◽  
Kei Kamide ◽  
Hiromi Rakugi ◽  
Toshio Ogihara ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Uric Acid ◽  
Essential Hypertension ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Ventricular Mass
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