scholarly journals sel-7, a Positive Regulator of lin-12 Activity, Encodes a Novel Nuclear Protein in Caenorhabditis elegans

Genetics ◽  
2004 ◽  
Vol 166 (1) ◽  
pp. 151-160 ◽  
Author(s):  
Jiabin Chen ◽  
Xiajun Li ◽  
Iva Greenwald
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Protein ◽  
Positive Regulator

scholarly journals lin-8, Which Antagonizes Caenorhabditis elegans Ras-Mediated Vulval Induction, Encodes a Novel Nuclear Protein That Interacts With the LIN-35 Rb Protein

Genetics ◽  
2005 ◽  
Vol 171 (3) ◽  
pp. 1017-1031 ◽  
Author(s):  
Ewa M. Davison ◽  
Melissa M. Harrison ◽  
Albertha J. M. Walhout ◽  
Marc Vidal ◽  
H. Robert Horvitz
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Protein ◽  
Rb Protein

Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans

2007 ◽  
Vol 313 (7) ◽  
pp. 1460-1472 ◽  
Author(s):  
Qiongmei Ji ◽  
Cheng-Han Huang ◽  
Jianbin Peng ◽  
Sarwar Hashmi ◽  
Tianzhang Ye ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Protein

scholarly journals Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4

IUBMB Life ◽  
2009 ◽  
Vol 61 (12) ◽  
pp. 1153-1158 ◽  
Author(s):  
Hyeon-Ok Jin ◽  
Sung-Keum Seo ◽  
Sang-Hyeok Woo ◽  
Tae-Boo Choe ◽  
Seok-Il Hong ◽  
...  
Keyword(s):  
Transcriptional Activation ◽  
Nuclear Protein ◽  
Positive Regulator

scholarly journals The Caenorhabditis elegans Gene mfap-1 Encodes a Nuclear Protein That Affects Alternative Splicing

PLoS Genetics ◽  
2012 ◽  
Vol 8 (7) ◽  
pp. e1002827 ◽  
Author(s):  
Long Ma ◽  
Xiaoyang Gao ◽  
Jintao Luo ◽  
Liange Huang ◽  
Yanling Teng ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Caenorhabditis Elegans ◽  
Nuclear Protein

scholarly journals SMU-2 and SMU-1, Caenorhabditis elegans Homologs of Mammalian Spliceosome-Associated Proteins RED and fSAP57, Work Together To Affect Splice Site Choice

2004 ◽  
Vol 24 (15) ◽  
pp. 6811-6823 ◽  
Author(s):  
Angela K. Spartz ◽  
Robert K. Herman ◽  
Jocelyn E. Shaw
Keyword(s):  
Caenorhabditis Elegans ◽  
Splice Site ◽  
Nuclear Protein ◽  
Core Protein ◽  
Protein A ◽  
Nonsense Mutations ◽  
Associated Proteins ◽  
Mutant Phenotypes

ABSTRACT Mutations in the Caenorhabditis elegans gene smu-2 suppress mec-8 and unc-52 mutations. It has been proposed that MEC-8 regulates the alternative splicing of unc-52 transcripts, which encode the core protein of perlecan, a basement membrane proteoglycan. We show that mutation in smu-2 leads to enhanced accumulation of transcripts that skip exon 17, but not exon 18, of unc-52, which explains our finding that smu-2 mutations suppress the uncoordination conferred by nonsense mutations in exon 17, but not in exon 18, of unc-52. We conclude that smu-2 encodes a ubiquitously expressed nuclear protein that is 40% identical to the human RED protein, a component of purified spliceosomes. The effects of smu-2 mutation on both unc-52 pre-mRNA splicing and the suppression of mec-8 and unc-52 mutant phenotypes are indistinguishable from the effects of mutation in smu-1, a gene that encodes a protein that is 62% identical to human spliceosome-associated protein fSAP57. We provide evidence that SMU-2 protects SMU-1 from degradation in vivo. In vitro and in vivo coimmunoprecipitation experiments indicate that SMU-2 and SMU-1 bind to each other. We propose that SMU-2 and SMU-1 function together to regulate splice site choice in the pre-mRNAs of unc-52 and other genes.

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