scholarly journals Role of theCaenorhabditis elegansMultidrug Resistance Gene,mrp-4, in Gut Granule Differentiation

Genetics ◽  
2007 ◽  
Vol 177 (3) ◽  
pp. 1569-1582 ◽  
Author(s):  
Erin Currie ◽  
Brian King ◽  
Andrea L. Lawrenson ◽  
Lena K. Schroeder ◽  
Aaron M. Kershner ◽  
...  
Keyword(s):  
Resistance Gene

scholarly journals Expression of the aac(6′)-Ib-cr Gene in Class 1 Integrons

2017 ◽  
Vol 61 (5) ◽  
Author(s):  
Sophie Raherison ◽  
Thomas Jove ◽  
Margaux Gaschet ◽  
Emilie Pinault ◽  
Aurore Tabesse ◽  
...  
Keyword(s):  
Amino Acids ◽  
Resistance Gene ◽  
Gene Cassette ◽  
Quinolone Resistance ◽  
Start Codon ◽  
Class 1 Integrons ◽  
Alternative Start Codon ◽  
Class 1

ABSTRACT aac(6′)-Ib-cr is a plasmid-mediated quinolone resistance gene embedded within a gene cassette, most often within an integron. It confers resistance to quinolones and aminoglycosides. We investigated the role of a 101-bp fragment frequently present upstream of the aac(6′)-Ib-cr gene cassette and found that it contributes to the expression of aac(6′)-Ib-cr and provides an alternative start codon, confirming the length of the AAC(6′)-Ib-cr protein to 199 amino acids.

scholarly journals Potential Role of Veillonella spp. as a Reservoir of Transferable Tetracycline Resistance in the Oral Cavity

2006 ◽  
Vol 50 (8) ◽  
pp. 2866-2868 ◽  
Author(s):  
D. Ready ◽  
J. Pratten ◽  
A. P. Roberts ◽  
R. Bedi ◽  
P. Mullany ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Resistance Gene ◽  
Resistance Genes ◽  
Potential Role ◽  
Tetracycline Resistance ◽  
Tetracycline Resistance Genes

ABSTRACT Twelve out of 96 Veillonella spp. isolated from oral samples harbored tetracycline resistance genes. The most common resistance gene was tet(M). A tet(M)-positive Veillonella dispar strain was shown to transfer a Tn916-like element to four Streptococcus spp. by conjugation at a frequency of 5.2 × 10−6 to 4.5 × 10−5 per recipient.

scholarly journals Multidrug resistance gene (MDR1) - marker of therapeutic resistance and severity of disease

2009 ◽  
Vol 7 (3) ◽  
pp. 9-13
Author(s):  
Z A Mironova ◽  
V I Trofimov ◽  
M A Simakova ◽  
E D Iantchina ◽  
M V Dubina
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Therapeutic Resistance ◽  
Inadequate Response ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Multidrug Resistance Gene ◽  
Severity Of Disease ◽  
P Glycoprotein ◽  
Genes Expression

Genes polymorphism is known to be one of the causes of the inadequate response to drugs or drugs resistance. In the most of cases drugs influence depends on interaction of several products of genes expression, which influence on drugs pharmacokinetics and pharmacodynamics. Present article concerns the review of publications and results of original investigations concerning the multidrug resistance gene (MDRl) expression associations with P-glycoprotein-170 (Pgp-170) expression in different diseases and the role of Pgp-170 in distribution of drugs in tissues.

scholarly journals When resistance gene pyramids are not durable-the role of pathogen diversity

2018 ◽  
Vol 19 (3) ◽  
pp. 521-524 ◽  
Author(s):  
Remco Stam ◽  
Bruce A. McDonald
Keyword(s):  
Resistance Gene ◽  
Pathogen Diversity

scholarly journals Genome comparison implies the role of Wsm2 in membrane trafficking and protein degradation

2018 ◽  
Author(s):  
Guorong Zhang ◽  
Zhihua Hua
Keyword(s):  
Protein Degradation ◽  
Resistance Gene ◽  
Membrane Trafficking ◽  
Biological Function ◽  
Brachypodium Distachyon ◽  
Illegitimate Recombination ◽  
Grass Species ◽  
Wsmv Resistance ◽  
Chromosome 3B

Wheat streak mosaic virus (WSMV) causes streak mosaic disease in wheat (Triticum aestivum L.) and has been an important constraint limiting wheat production in many regions around the world. Wsm2 is the only resistance gene discovered in wheat genome and has been located in a short genomic region of its chromosome 3B. However, the sequence nature and the biological function of Wsm2 remain unknown due to the difficulty of genetic manipulation in wheat. In this study, we tested WSMV infectivity among wheat and its two closely related grass species, rice (Oryza sativa) and Brachypodium distachyon. Based on the phenotypic result and previous genomic studies, we developed a novel bioinformatics pipeline for interpreting a potential biological function of Wsm2 and its ancestor locus in wheat. In the WSMV resistance tests, we found that rice has a WMSV resistance gene while Brachypodium does not, which allowed us to hypothesize the presence of a Wsm2 ortholog in rice. Our OrthoMCL analysis of protein coding genes on wheat chromosome 3B and its syntenic chromosomes in rice and Brachypodium discovered 4,035 OrthoMCL groups as preliminary candidates of Wsm2 orthologs. Given that Wsm2 is likely duplicated through an intrachromosomal illegitimate recombination and that Wsm2 is dominant, we inferred that this new WSMV-resistance gene acquired an activation domain, lost an inhibition domain, or gained high expression compared to its ancestor locus. Through comparison, we identified that 67, 16, and 10 out of 4,035 OrthoMCL orthologous groups contain a rice member with 25% shorter or longer in length, or 10 fold more expression, respectively, than those from wheat and Brachypodium. Taken together, we predicted a total of 93 good candidates for a Wsm2 ancestor locus. All of these 93 candidates are not tightly linked with Wsm2, indicative of the role of illegitimate recombination in the birth of Wsm2. Further sequence analysis suggests that the protein products of Wsm2 may combat WSMV disease through a molecular mechanism involving protein degradation and/or membrane trafficking. The 93 putative Wsm2 ancestor loci discovered in this study could serve as good candidates for future genetic isolation of the true Wsm2 locus.

Poster #M2 INVESTIGATION OF THE ROLE OF ALLELIC VARIANTS OF MULTIDRUG RESISTANCE GENE (MDR1) ON CLOZAPINE RELATED LEUKOPENIA/AGRANULOCYTOSIS

2014 ◽  
Vol 153 ◽  
pp. S189-S190
Author(s):  
A. Elif Anil Yağcıoğlu ◽  
Gökhan Yoca ◽  
R. Özgür Karaca ◽  
Lokman Çevik ◽  
Melih O. Babaoğlu ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Multidrug Resistance Gene ◽  
Allelic Variants

scholarly journals Genome comparison implies the role of Wsm2 in membrane trafficking and protein degradation

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4678
Author(s):  
Guorong Zhang ◽  
Zhihua Hua
Keyword(s):  
Protein Degradation ◽  
Resistance Gene ◽  
Membrane Trafficking ◽  
Biological Function ◽  
Brachypodium Distachyon ◽  
Illegitimate Recombination ◽  
Grass Species ◽  
Wsmv Resistance ◽  
Chromosome 3B

Wheat streak mosaic virus (WSMV) causes streak mosaic disease in wheat (Triticum aestivum L.) and has been an important constraint limiting wheat production in many regions around the world. Wsm2 is the only resistance gene discovered in wheat genome and has been located in a short genomic region of its chromosome 3B. However, the sequence nature and the biological function of Wsm2 remain unknown due to the difficulty of genetic manipulation in wheat. In this study, we tested WSMV infectivity among wheat and its two closely related grass species, rice (Oryza sativa) and Brachypodium distachyon. Based on the phenotypic result and previous genomic studies, we developed a novel bioinformatics pipeline for interpreting a potential biological function of Wsm2 and its ancestor locus in wheat. In the WSMV resistance tests, we found that rice has a WMSV resistance gene while Brachypodium does not, which allowed us to hypothesize the presence of a Wsm2 ortholog in rice. Our OrthoMCL analysis of protein coding genes on wheat chromosome 3B and its syntenic chromosomes in rice and Brachypodium discovered 4,035 OrthoMCL groups as preliminary candidates of Wsm2 orthologs. Given that Wsm2 is likely duplicated through an intrachromosomal illegitimate recombination and that Wsm2 is dominant, we inferred that this new WSMV-resistance gene acquired an activation domain, lost an inhibition domain, or gained high expression compared to its ancestor locus. Through comparison, we identified that 67, 16, and 10 out of 4,035 OrthoMCL orthologous groups contain a rice member with 25% shorter or longer in length, or 10 fold more expression, respectively, than those from wheat and Brachypodium. Taken together, we predicted a total of 93 good candidates for a Wsm2 ancestor locus. All of these 93 candidates are not tightly linked with Wsm2, indicative of the role of illegitimate recombination in the birth of Wsm2. Further sequence analysis suggests that the protein products of Wsm2 may combat WSMV disease through a molecular mechanism involving protein degradation and/or membrane trafficking. The 93 putative Wsm2 ancestor loci discovered in this study could serve as good candidates for future genetic isolation of the true Wsm2 locus.

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