scholarly journals Multidrug resistance gene (MDR1) - marker of therapeutic resistance and severity of disease

2009 ◽  
Vol 7 (3) ◽  
pp. 9-13
Author(s):  
Z A Mironova ◽  
V I Trofimov ◽  
M A Simakova ◽  
E D Iantchina ◽  
M V Dubina
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Therapeutic Resistance ◽  
Inadequate Response ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Multidrug Resistance Gene ◽  
Severity Of Disease ◽  
P Glycoprotein ◽  
Genes Expression

Genes polymorphism is known to be one of the causes of the inadequate response to drugs or drugs resistance. In the most of cases drugs influence depends on interaction of several products of genes expression, which influence on drugs pharmacokinetics and pharmacodynamics. Present article concerns the review of publications and results of original investigations concerning the multidrug resistance gene (MDRl) expression associations with P-glycoprotein-170 (Pgp-170) expression in different diseases and the role of Pgp-170 in distribution of drugs in tissues.

scholarly journals Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents

1989 ◽  
Vol 264 (30) ◽  
pp. 18031-18040
Author(s):  
L A Mickley ◽  
S E Bates ◽  
N D Richert ◽  
S Currier ◽  
S Tanaka ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Multidrug Resistance Gene ◽  
P Glycoprotein ◽  
Differentiating Agents ◽  
Mdr 1

Expression of Multidrug Resistance Gene Product (P-Glycoprotein) in Transitional Cell Carcinomas of the Upper Urinary Tract

1994 ◽  
Vol 26 (4) ◽  
pp. 327-333 ◽  
Author(s):  
Nobuo Shinohara ◽  
Katsuya Nonomura ◽  
Fujio Takakura ◽  
Mika Hamada ◽  
H. Barton Grossman ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Urinary Tract ◽  
Resistance Gene ◽  
Gene Product ◽  
Transitional Cell ◽  
Upper Urinary Tract ◽  
Multidrug Resistance Gene ◽  
P Glycoprotein

scholarly journals Binding diversity of antibodies against external and internal epitopes of the multidrug resistance gene product P-glycoprotein

Cytometry ◽  
1995 ◽  
Vol 20 (3) ◽  
pp. 228-237 ◽  
Author(s):  
G. Lehne ◽  
P. De Angelis ◽  
O. P. F. Clausen ◽  
T. Egeland ◽  
T. Tsuruo ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Gene Product ◽  
Multidrug Resistance Gene ◽  
P Glycoprotein
Sign in / Sign up

Export Citation Format

Share Document