scholarly journals Double-Strand Break Repair Assays Determine Pathway Choice and Structure of Gene Conversion Events inDrosophila melanogaster

2013 ◽  
Vol 4 (3) ◽  
pp. 425-432 ◽  
Author(s):  
Anthony T. Do ◽  
Joseph T. Brooks ◽  
Margot K. Le Neveu ◽  
Jeannine R. LaRocque
Keyword(s):  
Gene Conversion ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Pathway Choice ◽  
Break Repair

The Effect of Heterologous Insertions on Gene Conversion in Mitotically Dividing Cells in Drosophila melanogaster

Genetics ◽  
2002 ◽  
Vol 161 (1) ◽  
pp. 249-258
Author(s):  
Angela M Coveny ◽  
Tammy Dray ◽  
Gregory B Gloor
Keyword(s):  
Drosophila Melanogaster ◽  
Gene Conversion ◽  
Strand Break ◽  
Double Strand Break ◽  
P Element ◽  
Double Strand Break Repair ◽  
Break Site ◽  
In Trans ◽  
Break Repair ◽  
In Cis

Abstract We examined the influence that heterologous sequences of different sizes have on the frequency of double-strand-break repair by gene conversion in Drosophila melanogaster. We induced a double-strand break on one X chromosome in female flies by P-element excision. These flies contained heterologous insertions of various sizes located 238 bp from the break site in cis or in trans to the break, or both. We observed a significant decrease in double-strand-break repair with large heterologous insertions located either in cis or in trans to the break. Reestablishing the homology by including the same heterologous sequence in cis and in trans to the double-strand break restored the frequency of gene conversion to wild-type levels. In one instance, an allelic nonhomologous insertion completely abolished repair by homologous recombination. The results show that the repair of a double-strand break by gene conversion requires chromosome pairing in the local region of the double-strand break.

scholarly journals A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Chen-Chun Pai ◽  
Rachel S. Deegan ◽  
Lakxmi Subramanian ◽  
Csenge Gal ◽  
Sovan Sarkar ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Repair Pathway ◽  
Dna Double Strand Break ◽  
Pathway Choice ◽  
Break Repair

scholarly journals SHLD 2/ FAM 35A co‐operates with REV 7 to coordinate DNA double‐strand break repair pathway choice

2018 ◽  
Vol 37 (18) ◽  
Author(s):  
Steven Findlay ◽  
John Heath ◽  
Vincent M Luo ◽  
Abba Malina ◽  
Théo Morin ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Repair Pathway ◽  
Dna Double Strand Break ◽  
Pathway Choice ◽  
Break Repair

scholarly journals Role of 53BP1 in the Regulation of DNA Double-Strand Break Repair Pathway Choice

2014 ◽  
Vol 181 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Arun Gupta ◽  
Clayton R. Hunt ◽  
Sharmistha Chakraborty ◽  
Raj K. Pandita ◽  
John Yordy ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Repair Pathway ◽  
Dna Double Strand Break ◽  
Pathway Choice ◽  
Break Repair

scholarly journals A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining

Cell Reports ◽  
2013 ◽  
Vol 5 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Anastazja Grabarz ◽  
Josée Guirouilh-Barbat ◽  
Aurélia Barascu ◽  
Gaëlle Pennarun ◽  
Diane Genet ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Nonhomologous End Joining ◽  
Double Strand Break Repair ◽  
Repair Pathway ◽  
End Joining ◽  
Pathway Choice ◽  
Break Repair

scholarly journals New Tools to Study DNA Double-Strand Break Repair Pathway Choice

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77206 ◽  
Author(s):  
Daniel Gomez-Cabello ◽  
Sonia Jimeno ◽  
María Jesús Fernández-Ávila ◽  
Pablo Huertas
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Repair Pathway ◽  
Dna Double Strand Break ◽  
Pathway Choice ◽  
Break Repair
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