scholarly journals Gene conversion and deletion frequencies during double-strand break repair in human cells are controlled by the distance between direct repeats

2005 ◽  
Vol 33 (5) ◽  
pp. 1574-1580 ◽  
Author(s):  
E. Schildkraut
Keyword(s):  
Gene Conversion ◽  
Strand Break ◽  
Double Strand Break ◽  
Human Cells ◽  
Double Strand Break Repair ◽  
Direct Repeats ◽  
Break Repair

The Effect of Heterologous Insertions on Gene Conversion in Mitotically Dividing Cells in Drosophila melanogaster

Genetics ◽  
2002 ◽  
Vol 161 (1) ◽  
pp. 249-258
Author(s):  
Angela M Coveny ◽  
Tammy Dray ◽  
Gregory B Gloor
Keyword(s):  
Drosophila Melanogaster ◽  
Gene Conversion ◽  
Strand Break ◽  
Double Strand Break ◽  
P Element ◽  
Double Strand Break Repair ◽  
Break Site ◽  
In Trans ◽  
Break Repair ◽  
In Cis

Abstract We examined the influence that heterologous sequences of different sizes have on the frequency of double-strand-break repair by gene conversion in Drosophila melanogaster. We induced a double-strand break on one X chromosome in female flies by P-element excision. These flies contained heterologous insertions of various sizes located 238 bp from the break site in cis or in trans to the break, or both. We observed a significant decrease in double-strand-break repair with large heterologous insertions located either in cis or in trans to the break. Reestablishing the homology by including the same heterologous sequence in cis and in trans to the double-strand break restored the frequency of gene conversion to wild-type levels. In one instance, an allelic nonhomologous insertion completely abolished repair by homologous recombination. The results show that the repair of a double-strand break by gene conversion requires chromosome pairing in the local region of the double-strand break.

scholarly journals The ACF1 Complex Is Required for DNA Double-Strand Break Repair in Human Cells

2010 ◽  
Vol 40 (6) ◽  
pp. 976-987 ◽  
Author(s):  
Li Lan ◽  
Ayako Ui ◽  
Satoshi Nakajima ◽  
Kotomi Hatakeyama ◽  
Mikiko Hoshi ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Human Cells ◽  
Double Strand Break Repair ◽  
Dna Double Strand Break ◽  
Break Repair

scholarly journals Alteration of genetic recombination and double-strand break repair in human cells by progerin expression

DNA Repair ◽  
2020 ◽  
Vol 96 ◽  
pp. 102975 ◽  
Author(s):  
Celina J. Komari ◽  
Anne O. Guttman ◽  
Shelby R. Carr ◽  
Taylor L. Trachtenberg ◽  
Elise A. Orloff ◽  
...  
Keyword(s):  
Genetic Recombination ◽  
Strand Break ◽  
Double Strand Break ◽  
Human Cells ◽  
Double Strand Break Repair ◽  
Break Repair

Double-strand Break Repair in Human Cells

2000 ◽  
Vol 65 (0) ◽  
pp. 315-322 ◽  
Author(s):  
S.C. WEST ◽  
C. CHAPPELL ◽  
L.A. HANAKAHI ◽  
J.-Y. MASSON ◽  
M.J. MCILWRAITH ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Human Cells ◽  
Double Strand Break Repair ◽  
Break Repair
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