scholarly journals The use of degradable nerve conduits for human nerve repair: A review of the literature

2005 ◽  
Vol 2 (1) ◽  
pp. 39-43 ◽  
Author(s):  
M. F. Meek ◽  
K. Jansen ◽  
P. H. Robinson
Keyword(s):  
Nerve Repair ◽  
Review Of The Literature ◽  
Nerve Conduits ◽  
Human Nerve

scholarly journals The Use of Degradable Nerve Conduits for Human Nerve Repair: A Review of the Literature

2005 ◽  
Vol 2 (1) ◽  
pp. 39-43 ◽  
Author(s):  
M. F. Meek ◽  
K. Jansen ◽  
P. H. Robinson
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Nerve Repair ◽  
Experimental Studies ◽  
Review Of The Literature ◽  
Nerve Grafts ◽  
Nerve Guides ◽  
Clinical Challenge ◽  
Nerve Conduits ◽  
Human Nerve

The management of peripheral nerve injury continues to be a major clinical challenge. The most widely used technique for bridging defects in peripheral nerves is the use of autologous nerve grafts. This technique, however, has some disadvantages. Many alternative experimental techniques have thus been developed, such as degradable nerve conduits. Degradable nerve guides have been extensively studied in animal experimental studies. However, the repair of human nerves by degradable nerve conduits has been limited to only a few clinical studies. In this paper, an overview of the available international published literature on degradable nerve conduits for bridging human peripheral nerve defects is presented for literature available until 2004. Also, the philosophy on the use of nerve guides and nerve grafts is given.

Luminal Fillers in Nerve Conduits for Peripheral Nerve Repair

2006 ◽  
Vol 57 (4) ◽  
pp. 462-471 ◽  
Author(s):  
Michael B. Chen ◽  
Feng Zhang ◽  
William C. Lineaweaver
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair ◽  
Nerve Conduits

The influence of nerve conduits diameter in motor nerve recovery after segmental nerve repair

Microsurgery ◽  
2014 ◽  
Vol 34 (8) ◽  
pp. 646-652 ◽  
Author(s):  
Guilherme Giusti ◽  
Richard H. Shin ◽  
Joo-Yup Lee ◽  
Tiago G. Mattar ◽  
Allen T. Bishop ◽  
...  
Keyword(s):  
Motor Nerve ◽  
Nerve Repair ◽  
Nerve Conduits ◽  
Segmental Nerve ◽  
Nerve Recovery

scholarly journals Nerve Repair Using Decellularized Nerve Grafts in Rat Models. A Review of the Literature

2018 ◽  
Vol 12 ◽  
Author(s):  
Arianna B. Lovati ◽  
Daniele D’Arrigo ◽  
Simonetta Odella ◽  
Pierluigi Tos ◽  
Stefano Geuna ◽  
...  
Keyword(s):  
Nerve Repair ◽  
Review Of The Literature ◽  
Rat Models ◽  
Nerve Grafts

Spatially Controlled Delivery of Neurotrophic Factors in Silk Fibroin–Based Nerve Conduits for Peripheral Nerve Repair

2011 ◽  
Vol 67 (2) ◽  
pp. 147-155 ◽  
Author(s):  
Yen-Chih Lin ◽  
Mostafa Ramadan ◽  
Marie Hronik-Tupaj ◽  
David L. Kaplan ◽  
Brian J. Philips ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Silk Fibroin ◽  
Neurotrophic Factors ◽  
Nerve Repair ◽  
Controlled Delivery ◽  
Peripheral Nerve Repair ◽  
Nerve Conduits

TISSUE ENGINEERING FOR NERVE REPAIR

2006 ◽  
Vol 18 (03) ◽  
pp. 100-110 ◽  
Author(s):  
YI-CHENG HUANG ◽  
YI-YOU HUANG
Keyword(s):  
Nervous System ◽  
Nerve Repair ◽  
The Body ◽  
Heating Process ◽  
Supporting Cells ◽  
Nerve Conduits ◽  
Mature Neurons ◽  
Solvent Systems ◽  
System Physiology ◽  
Guidance Channels

Nerve regeneration is a complex biological phenomenon. Once the nervous system is impaired, its recovery is difficult and malfunctions in other parts of the body may occur because mature neurons don't undergo cell division. To increase the prospects of axonal regeneration and functional recovery, researches have focused on designing “nerve guidance channels” or “nerve conduits”. For developing tissue engineered nerve conduits, four components come to mind, including a scaffold for axonal proliferation, supporting cells such as Schwann cells, growth factors, and extracelluar matrix. This article reviews the nervous system physiology, the factors that are critical for nerve repair, and the advanced technologies that are explored to fabricate nerve conduits. Furthermore, we also introduce a new method we developed to create longitudinally oriented channels within biodegradable polymers, Chitosan and PLGA, using a combined lyophilizing and wire-heating process. This innovative method using Ni-Cr wires as mandrels to create nerve guidance channels. The process is easy, straightforward, highly reproducible, and could easily be tailored to other polymer and solvent systems. These scaffolds could be useful for guided regeneration after transection injury in either the peripheral nerve or spinal cord.

scholarly journals Additive Manufacturing of Nerve Decellularized Extracellular Matrix-Contained Polyurethane Conduits for Peripheral Nerve Regeneration

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1612 ◽  
Author(s):  
Chen ◽  
Chen ◽  
Ng ◽  
Lou ◽  
Chen ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Nerve Regeneration ◽  
Nerve Repair ◽  
Sensory Information ◽  
Cellular Adhesion ◽  
Electrical Signal ◽  
Potential Candidate ◽  
Body Parts ◽  
Digital Light Processing ◽  
Nerve Conduits

The nervous system is the part of our body that plays critical roles in the coordination of actions and sensory information as well as communication between different body parts through electrical signal transmissions. Current studies have shown that patients are likely to experience a functional loss if they have to go through a nerve repair for >15 mm lesion. The ideal treatment methodology is autologous nerve transplant, but numerous problems lie in this treatment method, such as lack of harvesting sites. Therefore, researchers are attempting to fabricate alternatives for nerve regeneration, and nerve conduit is one of the potential alternatives for nerve regeneration. In this study, we fabricated polyurethane/polydopamine/extracellular matrix (PU/PDA/ECM) nerve conduits using digital light processing (DLP) technology and assessed for its physical properties, biodegradability, cytocompatibility, neural related growth factor, and proteins secretion and expression and its potential in allowing cellular adhesion and proliferation. It was reported that PU/PDA/ECM nerve conduits were more hydrophilic and allowed enhanced cellular adhesion, proliferation, expression, and secretion of neural-related proteins (collagen I and laminin) and also enhanced expression of neurogenic proteins, such as nestin and microtubule-associated protein 2 (MAP2). In addition, PU/PDA/ECM nerve conduits were reported to be non-cytotoxic, had sustained biodegradability, and had similar physical characteristics as PU conduits. Therefore, we believed that PU/PDA/ECM nerve conduits could be a potential candidate for future nerve-related research or clinical applications.

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