The influence of nerve conduits diameter in motor nerve recovery after segmental nerve repair

Microsurgery ◽  
2014 ◽  
Vol 34 (8) ◽  
pp. 646-652 ◽  
Author(s):  
Guilherme Giusti ◽  
Richard H. Shin ◽  
Joo-Yup Lee ◽  
Tiago G. Mattar ◽  
Allen T. Bishop ◽  
...  
Keyword(s):  
Motor Nerve ◽  
Nerve Repair ◽  
Nerve Conduits ◽  
Segmental Nerve ◽  
Nerve Recovery

Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity

2004 ◽  
Vol 19 (1) ◽  
pp. 50-60 ◽  
Author(s):  
Derick G. Wansink ◽  
Wilma Peters ◽  
Iris Schaafsma ◽  
Roger P. M. Sutmuller ◽  
Frank Oerlemans ◽  
...  
Keyword(s):  
Motor Nerve ◽  
Nerve Repair ◽  
Tyrosine Phosphatase ◽  
Sensory Nerve ◽  
Thymocyte Development ◽  
Morphological Alterations ◽  
Nerve Recovery ◽  
Significant Impairment ◽  
Human Ortholog ◽  
Mild Impairment

Mouse PTP-BL is a large, nontransmembrane protein tyrosine phosphatase of unclear physiological function that consists of a KIND domain, a FERM domain, five PDZ domains, and a COOH-terminal catalytic PTP domain. PTP-BL and its human ortholog PTP-BAS have been proposed to play a role in the regulation of microfilament dynamics, cytokinesis, apoptosis, and neurite outgrowth. To investigate the biological function of PTP-BL enzyme activity, we have generated mice that lack the PTP-BL PTP moiety. These PTP-BLΔP/ΔP mice are viable and fertile and do not present overt morphological alterations. Although PTP-BL is expressed in most hematopoietic cell lineages, no alterations of thymocyte development in PTP-BLΔP/ΔP mice could be detected. Sciatic nerve lesioning revealed that sensory nerve recovery is unaltered in these mice. In contrast, a very mild but significant impairment of motor nerve repair was observed. Our findings exclude an essential role for PTP-BL as a phosphotyrosine phosphatase and rather are in line with a role as scaffolding or anchoring molecule.

scholarly journals Sciatic nerve regeneration in rats by a nerve conduit engineering with a membrane derived from natural latex

2012 ◽  
Vol 27 (12) ◽  
pp. 885-891 ◽  
Author(s):  
Marcos Vinícius Muniz Ganga ◽  
Joaquim Coutinho-Netto ◽  
Benedicto Oscar Colli ◽  
Wilson Marques Junior ◽  
Carlos Henrique Rocha Catalão ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Motor Nerve ◽  
Nerve Repair ◽  
Neural Regeneration ◽  
Male Adult ◽  
Electrophysiological Response ◽  
Nerve Recovery ◽  
Sciatic Nerve Regeneration ◽  
Gastrocnemius Muscles

PURPOSE: To evaluate the capacity of natural latex membrane to accelerate and improve the regeneration quality of the of rat sciatic nerves. METHODS: Forty male adult Wistar rats were used, anesthetized and operated to cut the sciatic nerve and receive an autograft or a conduit made with a membrane derived from natural latex (Hevea brasiliensis). Four or eight weeks after surgery, to investigate motor nerve recovery, we analyzed the neurological function by walking pattern (footprints analysis and computerized treadmill), electrophysiological evaluation and histological analysis of regenerated nerve (autologous nerve graft or tissue cables between the nerve stumps), and anterior tibial and gastrocnemius muscles. RESULTS: All functional and morphological analysis showed that the rats transplanted with latex conduit had a better neurological recovery than those operated with autologous nerve: quality of footprints, performance on treadmill (p<0.01), electrophysiological response (p<0.05), and quality of histological aspects on neural regeneration. CONCLUSION: The data reported showed behavioral and functional recovery in rats implanted with latex conduit for sciatic nerve repair, supporting a complete morphological and physiological regeneration of the nerve.

Muscle-derived GDNF facilitates motor nerve recovery following sciatic nerve crush injury

2007 ◽  
Vol 205 (3) ◽  
pp. S92
Author(s):  
Terence M. Myckatyn ◽  
Christina Kenney ◽  
Alice Tong ◽  
Jessica Duan ◽  
Daniel Hunter ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Motor Nerve ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Recovery ◽  
Nerve Crush Injury

Luminal Fillers in Nerve Conduits for Peripheral Nerve Repair

2006 ◽  
Vol 57 (4) ◽  
pp. 462-471 ◽  
Author(s):  
Michael B. Chen ◽  
Feng Zhang ◽  
William C. Lineaweaver
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Peripheral Nerve Repair ◽  
Nerve Conduits

Enhancement of Neuromuscular Recovery after Nerve Repair in Primates

1987 ◽  
Vol 12 (2) ◽  
pp. 211-217
Author(s):  
MARIE A. BADALAMENTE ◽  
L. C. HURST ◽  
S. B. PAUL ◽  
A. STRACHER
Keyword(s):  
Protease Inhibitor ◽  
Functional Recovery ◽  
Nerve Conduction Velocity ◽  
Motor Nerve ◽  
Nerve Repair ◽  
Sensory Nerve ◽  
Motor Nerve Conduction Velocity ◽  
Primate Model ◽  
Once Daily ◽  
Motor Nerve Conduction

This investigation describes the use of the calcium-activated protease inhibitor, leupeptin, as an adjunctive therapy to the microsurgical repair of median nerves in a primate model. Our results indicate that leupeptin facilitates morphological recovery in denervated thenar muscles and in distal sensory and mixed motor-sensory nerve trunks and functional recovery measured by motor nerve conduction velocity. Toxicological testing of leupeptin showed that, when administered at a dose of 12mg/kg, intramuscularly, once daily, haematological and clotting profiles were not adversely affected.

Spatially Controlled Delivery of Neurotrophic Factors in Silk Fibroin–Based Nerve Conduits for Peripheral Nerve Repair

2011 ◽  
Vol 67 (2) ◽  
pp. 147-155 ◽  
Author(s):  
Yen-Chih Lin ◽  
Mostafa Ramadan ◽  
Marie Hronik-Tupaj ◽  
David L. Kaplan ◽  
Brian J. Philips ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Silk Fibroin ◽  
Neurotrophic Factors ◽  
Nerve Repair ◽  
Controlled Delivery ◽  
Peripheral Nerve Repair ◽  
Nerve Conduits

scholarly journals Recovery of Motor Function after Mixed and Motor Nerve Repair with Processed Nerve Allograft

2019 ◽  
Vol 7 (3) ◽  
pp. e2163 ◽  
Author(s):  
Bauback Safa ◽  
Jaimie T. Shores ◽  
John V. Ingari ◽  
Renata V. Weber ◽  
Mickey Cho ◽  
...  
Keyword(s):  
Motor Function ◽  
Motor Nerve ◽  
Nerve Repair ◽  
Recovery Of Motor Function

scholarly journals Sex differences in neuro(auto)immunity and chronic sciatic nerve pain

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Katja Linher-Melville ◽  
Anita Shah ◽  
Gurmit Singh
Keyword(s):  
Chronic Pain ◽  
Sex Differences ◽  
Immune Cells ◽  
Immune Cell ◽  
Nerve Repair ◽  
Specific Treatment ◽  
Neural Firing ◽  
Biological Sex ◽  
Treatment Regimens ◽  
Nerve Recovery

AbstractChronic pain occurs with greater frequency in women, with a parallel sexually dimorphic trend reported in sufferers of many autoimmune diseases. There is a need to continue examining neuro-immune-endocrine crosstalk in the context of sexual dimorphisms in chronic pain. Several phenomena in particular need to be further explored. In patients, autoantibodies to neural antigens have been associated with sensory pathway hyper-excitability, and the role of self-antigens released by damaged nerves remains to be defined. In addition, specific immune cells release pro-nociceptive cytokines that directly influence neural firing, while T lymphocytes activated by specific antigens secrete factors that either support nerve repair or exacerbate the damage. Modulating specific immune cell populations could therefore be a means to promote nerve recovery, with sex-specific outcomes. Understanding biological sex differences that maintain, or fail to maintain, neuroimmune homeostasis may inform the selection of sex-specific treatment regimens, improving chronic pain management by rebalancing neuroimmune feedback. Given the significance of interactions between nerves and immune cells in the generation and maintenance of neuropathic pain, this review focuses on sex differences and possible links with persistent autoimmune activity using sciatica as an example.

Repair of Motor Nerve Defects: Comparison of Suture and Fibrin Adhesive Techniques

1989 ◽  
Vol 100 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Shigeki Nishihira ◽  
Thomas V. McCaffrey
Keyword(s):  
Sciatic Nerve ◽  
Motor Nerve ◽  
Nerve Repair ◽  
Suture Technique ◽  
Nerve Graft ◽  
Tissue Adhesive ◽  
Muscle Twitch ◽  
Fibrin Adhesive ◽  
Fibrin Tissue Adhesive ◽  
Nerve Muscle

Two groups of rats were used to evaluate the results of nerve repair using fibrin tissue adhesive. In one group of 10 rats, a simple neurotomy of the sciatic nerve was performed. In the second group of 10 rats, a 1-cm segment of sciatic nerve was excised bilaterally and used as an autogenous nerve graft. The neurotomy and the nerve graft were repaired on one side by microsurgical suture technique using 10-0 nylon suture. The opposite side was repaired using fibrin adhesive. The results of the repair were assessed at 12 weeks. Functional assessment of nerve regeneration was performed in those rats with intact repair sites. Nerve-muscle twitch strengths were not significantly different ( p > 0.05) between nerves repaired using suture and fibrin adhesive; however, compound active potential parameters were significantly better in nerve grafts repaired using suture technique ( p < 0.05).

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