Surface topology

Author(s):  
Peter A. Firby ◽  
Cyril F. Gardiner
Keyword(s):  
Author(s):  
Marek Malecki ◽  
J. Victor Small ◽  
James Pawley

The relative roles of adhesion and locomotion in malignancy have yet to be clearly established. In a tumor, subpopulations of cells may be recognized according to their capacity to invade neighbouring tissue,or to enter the blood stream and metastasize. The mechanisms of adhesion and locomotion are themselves tightly linked to the cytoskeletal apparatus and cell surface topology, including expression of integrin receptors. In our studies on melanomas with Fluorescent Microscopy (FM) and Cell Sorter(FACS), we noticed that cells in cultures derived from metastases had more numerous actin bundles, then cells from primary foci. Following this track, we attempted to develop technology allowing to compare ultrastructure of these cells using correlative Transmission Electron Microscopy(TEM) and Low Voltage Scanning Electron Microscopy(LVSEM).


2007 ◽  
Vol 30 (4) ◽  
pp. 77
Author(s):  
Derek Cool ◽  
Shi Sherebrin ◽  
Jonathan Izawa ◽  
Joseph Chin ◽  
Aaron Fenster

Introduction: Transrectal ultrasound (TRUS) prostate biopsy (Bx) is currently confined to 2D information to both target and record 3D Bx locations. Accurate placement of Bx needles cannot be verified without 3D information, and recording Bx sites in 2D does not provide sufficient information to accurately guide the high incidence of repeat Bx. We have designed a 3D TRUS prostate Bx system that augments the current 2D TRUS system and provides tools for biopsy-planning, needle guidance, and recording of the biopsy core locations entirely in 3D. Methods: Our Bx system displays a 3D model of the patient’s prostate, which is generated intra-procedure from a collection of 2D TRUS images, representative of the particular prostate shape. Bx targets are selected, needle guidance is facilitated, and 3D Bx sites are recorded within the 3D context of the prostate model. The complete 3D Bx system was validated, in vitro, by performing standard ten-core Bx on anatomical phantoms of two patient’s prostates. The accuracy of the needle-guidance, Bx location recording, and 3D model volume and surface topology were validated against a CT gold standard. Results: The Bx system successfully reconstructed the 3D patient prostate models with a mean volume error of 3.2 ± 7.6%. Using the 3D system, needles were accurately guided to the pre-determined targets with a mean error of 2.26 ± 1.03 mm and the 3D locations of the Bx cores were accurately recorded with a mean distance error of 1.47 ± 0.79 mm. Conclusion: We have successfully developed a 3D TRUS prostate biopsy system and validated the system in vitro. A pilot study has been initiated to apply the system clinically.


2020 ◽  
Vol 527 ◽  
pp. 146902 ◽  
Author(s):  
Maksim M. Kharkov ◽  
Andrey V. Kaziev ◽  
Daria V. Danilyuk ◽  
Margarita S. Kukushkina ◽  
Nikolay A. Chernyh ◽  
...  

2013 ◽  
Vol 102 (2) ◽  
pp. 532-539 ◽  
Author(s):  
Colton McNichols ◽  
Justin Wilkins ◽  
Atsutoshi Kubota ◽  
Yan T. Shiu ◽  
Samir M. Aouadi ◽  
...  

Author(s):  
Tristan Maquart ◽  
Thomas Elguedj ◽  
Anthony Gravouil ◽  
Michel Rochette

AbstractThis paper presents an effective framework to automatically construct 3D quadrilateral meshes of complicated geometry and arbitrary topology adapted for parametric studies. The input is a triangulation of the solid 3D model’s boundary provided from B-Rep CAD models or scanned geometry. The triangulated mesh is decomposed into a set of cuboids in two steps: pants decomposition and cuboid decomposition. This workflow includes an integration of a geometry-feature-aware pants-to-cuboids decomposition algorithm. This set of cuboids perfectly replicates the input surface topology. Using aligned global parameterization, patches are re-positioned on the surface in a way to achieve low overall distortion, and alignment to principal curvature directions and sharp features. Based on the cuboid decomposition and global parameterization, a 3D quadrilateral mesh is extracted. For different parametric instances with the same topology but different geometries, the MEG-IsoQuad method allows to have the same representation: isotopological meshes holding the same connectivity where each point on a mesh has an analogous one into all other meshes. Faithful 3D numerical charts of parametric geometries are then built using standard data-based techniques. Geometries are then evaluated in real-time. The efficiency and the robustness of the proposed approach are illustrated through a few parametric examples.


2021 ◽  
Vol 3 (4) ◽  
Author(s):  
Olugbenga O. Oluwasina ◽  
Bolaji P. Akinyele ◽  
Sunday J. Olusegun ◽  
Olayinka O. Oluwasina ◽  
Nelcy D. S. Mohallem

AbstractThe adverse environmental effects of petroleum-based packaging plastics have necessitated the need for eco-friendly bioplastics. Most bioplastics are starch-based and are not without drawbacks, hence there is the need for their properties to be improved. In this study, the effect of varying concentrations of dialdehyde starch and silica solutions on the physical, mechanical, biodegradable, surface topology, and thermal properties of the bioplastic films was examined. The additive concentrations were varied from 60 to 100%. The bioplastic films produced with dialdehyde starch solution recorded better moisture content (6.62–11.85%), bioplastic film solubility (4.23–7.90%), and tensile strength (1.63–3.06 MPa), against (11.24–14.26%), (7.77–19.27%) and (0.53–0.73 MPa) respectively for bioplastic films produced with silica solution. The atomic force microscopy analysis; root-mean-square roughness, kurtosis, and skewness revealed better miscibility and compatibility between the starch matrix and the dialdehyde solution than between the starch matrix and the silica solution. Bioplastic with added dialdehyde starch solution has better tensile strength and long biodegradability than that with silica solution. The research has demonstrated that bioplastic film produced with starch and dialdehyde starch solution has better properties than the one produced with starch and silica solution. The properties evaluation results of the bioplastic films thus demonstrated their aptness for food packaging applications. Graphic abstract


2021 ◽  
Vol 7 (17) ◽  
pp. eabd9275
Author(s):  
Samuel Beaulieu ◽  
Shuo Dong ◽  
Nicolas Tancogne-Dejean ◽  
Maciej Dendzik ◽  
Tommaso Pincelli ◽  
...  

Fermi surface is at the heart of our understanding of metals and strongly correlated many-body systems. An abrupt change in the Fermi surface topology, also called Lifshitz transition, can lead to the emergence of fascinating phenomena like colossal magnetoresistance and superconductivity. While Lifshitz transitions have been demonstrated for a broad range of materials by equilibrium tuning of macroscopic parameters such as strain, doping, pressure, and temperature, a nonequilibrium dynamical route toward ultrafast modification of the Fermi surface topology has not been experimentally demonstrated. Combining time-resolved multidimensional photoemission spectroscopy with state-of-the-art TDDFT+U simulations, we introduce a scheme for driving an ultrafast Lifshitz transition in the correlated type-II Weyl semimetal Td-MoTe2. We demonstrate that this nonequilibrium topological electronic transition finds its microscopic origin in the dynamical modification of the effective electronic correlations. These results shed light on a previously unexplored ultrafast scheme for controlling the Fermi surface topology in correlated quantum materials.


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