Dissecting the meiotic gene network in female embryonic germ cells

2014 ◽  
Author(s):  
Emilie Abby ◽  
Sophie Tourpin ◽  
Marie-Justine Guerquin ◽  
Bouffant Ronan Le ◽  
Rene Habert ◽  
...  
Keyword(s):  
Germ Cells ◽  
Gene Network ◽  
Embryonic Germ Cells ◽  
Meiotic Gene

scholarly journals Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P2 to direct migration of Drosophila embryonic germ cells

Cell Reports ◽  
2021 ◽  
Vol 34 (9) ◽  
pp. 108799
Author(s):  
Ji Hoon Kim ◽  
Caitlin D. Hanlon ◽  
Sunaina Vohra ◽  
Peter N. Devreotes ◽  
Deborah J. Andrew
Keyword(s):  
Germ Cells ◽  
Hedgehog Signaling ◽  
Actin Dynamics ◽  
Embryonic Germ Cells

scholarly journals Heterogeneity in imprinted methylation patterns of pluripotent embryonic germ cells derived from pre-migratory mouse germ cells

2008 ◽  
Vol 313 (2) ◽  
pp. 674-681 ◽  
Author(s):  
Tanya C. Shovlin ◽  
Gabriela Durcova-Hills ◽  
Azim Surani ◽  
Anne McLaren
Keyword(s):  
Germ Cells ◽  
Embryonic Germ Cells ◽  
Methylation Patterns

Derivation and Differentiation of Human Embryonic Germ Cells

2013 ◽  
pp. 347-356
Author(s):  
Michael J. Shamblott ◽  
Candace L. Kerr ◽  
Joyce Axelman ◽  
John W. Littlefield ◽  
Gregory O. Clark ◽  
...  
Keyword(s):  
Germ Cells ◽  
Embryonic Germ Cells

Derivation and Differentiation of Human Embryonic Germ Cells

2009 ◽  
pp. 381-390
Author(s):  
Michael J. Shamblott ◽  
Candace L. Kerr ◽  
Joyce Axelman ◽  
John W. Littlefield ◽  
Gregory O. Clark ◽  
...  
Keyword(s):  
Germ Cells ◽  
Embryonic Germ Cells

Derivation and Differentiation of Human Embryonic Germ Cells

2004 ◽  
pp. 459-470 ◽  
Author(s):  
Michael J. Shamblott ◽  
Candace L. Kerr ◽  
Joyce Axelman ◽  
John W. Littlefield ◽  
Gregory O. Clark ◽  
...  
Keyword(s):  
Germ Cells ◽  
Embryonic Germ Cells

scholarly journals Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Jin Zhang ◽  
Juan Dong ◽  
Weibing Qin ◽  
Congcong Cao ◽  
Yujiao Wen ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Germ Cell ◽  
Zinc Finger ◽  
Germ Cells ◽  
Cell Development ◽  
Knockout Mouse Model ◽  
Zinc Finger Transcription Factor ◽  
Germ Cell Development ◽  
Embryonic Germ Cells ◽  
Protein Levels

AbstractOvol2, a mouse homolog of Drosophila ovo, was identified as a zinc finger transcription factor predominantly expressed in testis. However, the function of Ovol2 in postnatal male germ cell development remains enigmatic. Here, we firstly examined the mRNA and protein levels of Ovol2 in developing mouse testes by RT-qPCR and western blot and found that both mRNA and protein of Ovol2 are continually expressed in postnatal developing testes from postnatal day 0 (P0) testes to adult testes (P56) and exhibits its higher level at adult testis. Further testicular immuno-staining revealed that OVOL2 is highly expressed in the spermatogonia, spermatocytes and round spermatids. Interestingly, our conditional ovol2 knockout mouse model show that loss of ovol2 in embryonic germ cells does not affect fecundity in mice. Our data also show that Ovol1 may have compensated for the loss of Ovol2 functions in germ cells. Overall, our data indicate that ovol2 is dispensable for germ cell development and spermatogenesis.

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