scholarly journals Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila

Development ◽  
2010 ◽  
Vol 137 (11) ◽  
pp. 1815-1823 ◽  
Author(s):  
A. D. Renault ◽  
P. S. Kunwar ◽  
R. Lehmann
Keyword(s):  
Phosphatase Activity ◽  
Germ Cells ◽  
Embryonic Germ Cells ◽  
Lipid Phosphate

Dissecting the meiotic gene network in female embryonic germ cells

2014 ◽  
Author(s):  
Emilie Abby ◽  
Sophie Tourpin ◽  
Marie-Justine Guerquin ◽  
Bouffant Ronan Le ◽  
Rene Habert ◽  
...  
Keyword(s):  
Germ Cells ◽  
Gene Network ◽  
Embryonic Germ Cells ◽  
Meiotic Gene

scholarly journals Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P2 to direct migration of Drosophila embryonic germ cells

Cell Reports ◽  
2021 ◽  
Vol 34 (9) ◽  
pp. 108799
Author(s):  
Ji Hoon Kim ◽  
Caitlin D. Hanlon ◽  
Sunaina Vohra ◽  
Peter N. Devreotes ◽  
Deborah J. Andrew
Keyword(s):  
Germ Cells ◽  
Hedgehog Signaling ◽  
Actin Dynamics ◽  
Embryonic Germ Cells

scholarly journals Heterogeneity in imprinted methylation patterns of pluripotent embryonic germ cells derived from pre-migratory mouse germ cells

2008 ◽  
Vol 313 (2) ◽  
pp. 674-681 ◽  
Author(s):  
Tanya C. Shovlin ◽  
Gabriela Durcova-Hills ◽  
Azim Surani ◽  
Anne McLaren
Keyword(s):  
Germ Cells ◽  
Embryonic Germ Cells ◽  
Methylation Patterns

Derivation and Differentiation of Human Embryonic Germ Cells

2013 ◽  
pp. 347-356
Author(s):  
Michael J. Shamblott ◽  
Candace L. Kerr ◽  
Joyce Axelman ◽  
John W. Littlefield ◽  
Gregory O. Clark ◽  
...  
Keyword(s):  
Germ Cells ◽  
Embryonic Germ Cells

Derivation and Differentiation of Human Embryonic Germ Cells

2009 ◽  
pp. 381-390
Author(s):  
Michael J. Shamblott ◽  
Candace L. Kerr ◽  
Joyce Axelman ◽  
John W. Littlefield ◽  
Gregory O. Clark ◽  
...  
Keyword(s):  
Germ Cells ◽  
Embryonic Germ Cells

Derivation and Differentiation of Human Embryonic Germ Cells

2004 ◽  
pp. 459-470 ◽  
Author(s):  
Michael J. Shamblott ◽  
Candace L. Kerr ◽  
Joyce Axelman ◽  
John W. Littlefield ◽  
Gregory O. Clark ◽  
...  
Keyword(s):  
Germ Cells ◽  
Embryonic Germ Cells

scholarly journals Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2

2005 ◽  
Vol 171 (4) ◽  
pp. 675-683 ◽  
Author(s):  
Hiroko Sano ◽  
Andrew D. Renault ◽  
Ruth Lehmann
Keyword(s):  
Drosophila Melanogaster ◽  
Axon Guidance ◽  
Germ Cells ◽  
Primordial Germ Cells ◽  
Lateral Migration ◽  
Migration Process ◽  
The Central Nervous System ◽  
Lipid Phosphate ◽  
Lipid Phosphate Phosphatases ◽  
Single Cluster

In most organisms, primordial germ cells (PGCs) arise far from the region where somatic gonadal precursors (SGPs) are specified. Although PGCs in general originate as a single cluster of cells, the somatic parts of the gonad form on each site of the embryo. Thus, to reach the gonad, PGCs not only migrate from their site of origin but also split into two groups. Taking advantage of high-resolution real-time imaging, we show that in Drosophila melanogaster PGCs are polarized and migrate directionally toward the SGPs, avoiding the midline. Unexpectedly, neither PGC attractants synthesized in the SGPs nor known midline repellents for axon guidance were required to sort PGCs bilaterally. Repellent activity provided by wunen (wun) and wunen-2 (wun-2) expressed in the central nervous system, however, is essential in this migration process and controls PGC survival. Our results suggest that expression of wun/wun-2 repellents along the migratory paths provides faithful control over the sorting of PGCs into two gonads and eliminates PGCs left in the middle of the embryo.

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