scholarly journals Effect of a single dose of ibuprofen lysinate before embryo transfer on pregnancy rates in cows

Reproduction ◽  
2001 ◽  
pp. 151-154 ◽  
Author(s):  
M Elli ◽  
B Gaffuri ◽  
A Frigerio ◽  
M Zanardelli ◽  
D Covini ◽  
...  
Keyword(s):  
Body Weight ◽  
Single Dose ◽  
Embryo Transfer ◽  
Embryo Implantation ◽  
Pregnancy Rates ◽  
Adjunctive Treatment ◽  
Control Group ◽  
Significant Difference ◽  
Enzyme Isoforms ◽  
And Control

Embryo implantation is a critical step in both cows and humans. The use of ibuprofen lysinate to enhance implantation has been investigated in cattle with the specific aim of improving pregnancy rates after embryo transfer. In this study, heifers (n = 100) were assigned randomly to one of two groups: one group was treated i.m. with 5 mg ibuprofen lysinate kg(-1) body weight 1 h before embryo transfer and a control group received vehicle only. A single embryo was transferred into each recipient cow. There was a significant difference in the number of pregnancies after embryo transfer between cows in the treated (41 of 50; 82%) and control (28 of 50; 56%) groups (P < 0.05). These data indicate that ibuprofen lysinate may be an effective adjunctive treatment for assisted reproduction in cattle. Further studies are needed to clarify whether this effect is associated with the reduction of cyclooxygenase enzyme isoforms during embryo transfer or whether other mechanisms are involved.

scholarly journals Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide

2018 ◽  
Vol 52 (4) ◽  
pp. 185-191
Author(s):  
Tomomi Nobashi ◽  
Tsuneo Saga ◽  
Yuji Nakamoto ◽  
Yoichi Shimizu ◽  
Sho Koyasu ◽  
...  
Keyword(s):  
Body Weight ◽  
Small Intestine ◽  
Low Dose ◽  
Control Group ◽  
High Dose ◽  
Fdg Uptake ◽  
Significant Difference ◽  
Mouse Small Intestine ◽  
Long Acting ◽  
And Control

AbstractObjective. This study investigated whether the metformin (Met)-induced enhanced intestinal uptake of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) is reduced by loperamide, a long-acting anti-diarrheal agent. Methods. Mean18F-FDG uptake in the mouse small intestine and colon with Met exposure was compared with that in control mice. In the Met group, high-dose (1.0 mg/kg body weight) and low-dose (0.1 mg/kg body weight) loperamide were introduced, and18F-FDG uptake in the small intestine and colon was compared with that of control mice administered high-dose loperamide. The percent injected dose of18F-FDG per gram of tissue (%ID/g) in the extracted tissues was then determined. Results.18F-FDG uptake increased significantly in the small intestine (0.64±0.06 vs. 1.01±0.15, p=0.040) and, especially, the colon (0.46±0.13 vs. 2.16±0.51, p<0.001) after Met exposure. Neither high-dose nor low-dose loperamide significantly reduced18F-FDG uptake in the small intestine (0.82±0.31 vs. 0.84±0.22, p=0.93 and 0.78±0.25 vs. 0.70±0.15, p=0.13, respectively) or colon (2.13±0.41 vs. 1.67±0.55, p=0.063 and 1.77±0.39 vs. 1.80±0.25, p=0.56, respectively). The colonic %ID/g was significantly higher in Met groups irrespective of loperamide introduction than in control group, whereas the significant difference in the small intestine was observed only between Met and control groups. Conclusion. Metformin increased18F-FDG uptake in intestines especially in colon. Loperamide administration partially, but not sufficiently, suppresses the Met-induced increased colonic uptake of18F-FDG.

scholarly journals The effect of acupuncture on the day of embryo transfer on the in vitro fertilization outcomes: An RCT

2020 ◽  
Author(s):  
Alamtaj Samsami Dehghani ◽  
Kaynoosh Homayouni ◽  
Zahra Kanannejad ◽  
Zeinab Kanannejad
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Pregnancy Rates ◽  
Control Group ◽  
Vitro Fertilization ◽  
Significant Difference ◽  
Before And After ◽  
Mother And Child ◽  
Child Hospital

Background: Acupuncture is an adjunct therapy to support infertile women received in vitro fertilization (IVF) treatment; however, the efficacy of this approach needs more evaluation. Objective: This randomized clinical trial (RCT) study aimed to evaluate the influence of acupuncture on reproductive outcomes in women undergoing IVF treatment. Materials and Methods: The study was carried out on 186 participants who had undergone IVF treatment in the Mother and Child Hospital between September 2015 and February 2016. Subjects were randomly divided into three groups: Acupuncture 25 min before embryo transfer (ET) (ACU1 group, n = 62), acupuncture 25 min before and after ET (ACU2 group, n = 62), and ET without acupuncture (control group, n = 62). Pregnancy rates (biochemical, clinical, and ongoing) were evaluated and compared between groups. Results: There were significant differences between the ACU1 group and the control group regarding biochemical (p = 0.005), clinical (p = 0.006), and ongoing (p = 0.007) pregnancies. Also, our results showed that two-session acupuncture (ACU2) lead to a significant reduction in frequency of biochemical (p = 0.002), clinical (p = 0.003), and ongoing (p = 0.01) pregnancy rates when compared to the one-session acupuncture (ACU1). No significant difference was found between the ACU2 and control groups regarding the aforementioned terms (p = 0.50). Conclusion: Acupuncture 25 min before ET significantly increased the IVF outcomes in women undergoing IVF compared with no acupuncture. Repeating acupuncture 25 min after ET did not improve the IVF outcome. Key words: Acupuncture, Embryo transfer, In vitro fertilization, Pregnancy rate.

scholarly journals Regulation of Integrin β3 Protein Secretion on Implantation Embryo of Mouse (Mus musculus L.) Induced by Oil Atsiri of Purple Nutsedge Tubers (Cyperus rotundus L.)

2019 ◽  
pp. 1-5
Author(s):  
Hendri Busman ◽  
Sutyarso . ◽  
Salman Farisi ◽  
Yulianty .
Keyword(s):  
Body Weight ◽  
Essential Oil ◽  
Female Mouse ◽  
Embryo Implantation ◽  
Cyperus Rotundus ◽  
Chemistry Laboratory ◽  
Control Group ◽  
Purple Nutsedge ◽  
Significant Difference ◽  
Β3 Integrin

Aims: This study aims to determine the regulation of β3 integrin protein in the period of embryo implantation after being induced by oil atsiri of purple nutsedge tubers. Study Design: The study employed a completely randomised design using four concentration levels repeated six times. Place and Duration of Study: Organic Chemistry Laboratory and Zoology Laboratory of Faculty of Mathematics and Natural Sciences University of Lampung, between June 2015 and April 2016. Methodology: This study used mouse as experimental animals with 24 female mouse, then mated with male mouse with a ratio (1 female: 1 male). After the vaginal plug was found in female mouse, then the essential oil of purple nutsedge tubers was induced orally (force-fed) according to the treatment dose. Each 6 female mice were grouped as a control group, and 3 treatment groups, consisting of controls (C) = 0.4 ml aquabides, treatment 1 (T1) = 4.5 mg/40g body weight, treatment 2 (T2) = 45 mg/40g body weight, and treatment 3 (T3) = 135 mg/40g body weight. After the one way Anova test, Ho is rejected, meaning there are significant differences and the analysis is continued with multiple comparison tests, in this case the Least Significant Difference (LSD) test is used. Results: The results shown that the induction of essential oils of purple nutsedge tubers can reduce the level of β3 integrin protein in uterus mouse significantly. Conclusion: It is suggested essential oil of purple nutsedge tubers has potential decrease and can reduce the level of β3 integrin protein in uterus mouse during the period of embryo implantation.

scholarly journals Doxorubicin Deteriorates the Histomorphology of the Kidneys of Albino Rats

2017 ◽  
Vol 15 (1) ◽  
pp. 40-43
Author(s):  
Anup Pandeya ◽  
Chandra Bhushan Jha ◽  
Smriti Karki ◽  
Gajendra Prashad Rauniar
Keyword(s):  
Body Weight ◽  
The Body ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Final Body Weight ◽  
Histological Features ◽  
Male And Female Rats ◽  
Significant Difference ◽  
And Control

Background and Objectives: Nephrotoxicity is one of the limiting factors for using doxorubicin as an anticancer chemotherapeutic. Reactive oxygen species and cytokines have been implicated in the nephrotoxicity induced by doxorubicin. The main objective of the present study is to identify and compare the histomorphological features in kidneys of albino rats and gross morphological features such as weight of rats and weight of the kidneys due to administration of doxorubicin. Materials and Methods: In the study, albino rats were taken as the animal model. Sixty animals were taken as the sample size. They were divided into two equal groups: experimental (n=30) and control (n=30). Rats of experimental group were treated with anticancer drug doxorubicin at a single intraperitoneal dose of 10 mg/kg body weight while the Control group of rats received a similar volume of 0.9% normal saline. The ethical clearance was taken prior to the research from IERB committee BPKIHS Dharan.  Results: Our results showed that there was high effect of drug in experimental groups of rats. It was seen that there was significant decrease in the body weight and weight of kidneys. The final body weight and kidney weight between experimental and control group showed the significant difference. Similarly there were no significant differences in the normal architecture between the male and female rats. The normal renal histological features were seen on the kidneys in the control group whereas the rats intervened with the drug had some disrupted histological features which reveal the toxicity of the drugs in the kidneys. Conclusion: The study showed toxicity of the drug in the kidneys of experimental groups of rats irrespective of gender and suggest that doxorubicin causes significant loss of the body weight and weight of kidneys and causes the disruption in the normal histological features.

scholarly journals Effect Of Vitamine AND Selenum On Immune Response Of CO - Baghdad Vaccine In Sheep.

2004 ◽  
Vol 45 (1) ◽  
pp. 55-66
Author(s):  
A. M.H. AL-Judi ◽  
R. H. Hameed ◽  
A. D. Salman
Keyword(s):  
Immune Response ◽  
Body Weight ◽  
Vitamin E ◽  
Antibody Titer ◽  
Control Group ◽  
Fourth Group ◽  
The Third ◽  
Significant Difference ◽  
And Control

This study was done on 57 Awassi pregnant ewes, divided in to 5 groups, the 1st control group, the second group received  E (900 mg) and Selenium (3mg), twicel.M.injections of vitamin the third group received one injection of vitamin E (900mg) and  feed  via selenium ( 3 mg), the fourth group received vitamin E block (1 gm) daily for two weeks, the fifth group received  vitamin E via feed block for one week (1gm daily), and all groups injected with C Baghdad vaccine.  This study had been shown a significant difference in antibody titer between treated groups and the control group, from2weeks post  titre vaccination There were significant difference in antibody (p<0.05) between lambs of treated and control group. While there were no significant difference in body weight of ewes and lambs,  production of treated and but was a significant difference in milk control group. 

87 Effect of Treatment with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) on Pregnancy Rates of Recipient Alpacas Post-Embryo Transfer

2018 ◽  
Vol 30 (1) ◽  
pp. 183
Author(s):  
H. W. Vivanco-Mackie ◽  
M. D. P. Salazar ◽  
M. Miguel-Gonzales ◽  
C. R. Youngs ◽  
M. Asparrin
Keyword(s):  
Body Weight ◽  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Tolfenamic Acid ◽  
Pregnancy Rates ◽  
Control Group ◽  
Chi Squared ◽  
Effect Of Treatment ◽  
The Difference ◽  
Live Fetus

The aim of the study was to improve the pregnancy rate in recipient alpacas using nonsteroidal anti-inflammatpry druds (NSAIDs) at time of embryo transfer. Because most NSAIDs are non-selective inhibitors of cyclooxygenases, which are the rate-limiting enzymes in the formation of prostaglandins, such treatment could temporarily block the production of prositaglandin F2α (PGF2α) and hence maintain corpus luetum (CL) activity long enough to support embryo development and pregnancy. The experiment was carried out in the Peruvian southern highlands (4,100 m elevation). Thirty-one adult alpaca donors were subjected to superovulation and embryo flushing as described previously (Vivanco-Mackie 2013 Proc. 29th Annu. Mtg. AETE, Istanbul, pp. 43-74; http://www.aete.eu/index.php/publications-aete/proceedings/2013/file). From the collected embryos, 20 grade A embryos were selected and transferred fresh into the recipients of the 2 experimental groups. All embryos were collected and transferred at 6.5 days post-mating of the donors with one embryo transferred per recipient. Recipient alpacas (n = 20) were synchronized and induced to ovulate after a selection made by ultrasonography, selecting as recipients the alpacas with follicles >8 mm and then exposing them to vasectomized males followed by IM injection of gonadotropin-releasing hormone (GnRH, 0.0084 mg of acetate of buserelin). Embryo transfers were made by laparoscopically aided laparotomy 6.5 days after ovulation induction as this method has been demonstrated to be more effective in previous trials compared with transcervical non-surgical transfers. At the time of embryo transfer, the recipients were randomly assigned to 1 of the 2 treatments according to the NSAID injected immediately after embryo transfer: Treatment 1 (10 alpacas) was an IM injection of meloxicam at 0.5 mg/kg of body weight; treatment 2 (10 alpacas) was an IM injection of tolfenamic acid at 3 mg/kg of body weight. At the pregnancy test by ultrasound scanning on Day 58 post-transfer, 30% (3/10) of the recipients had a live fetus in treatment 1, whereas treatment 2 had only 10% (1/10).The difference was not significant (P > 0.05) based on Chi-squared analysis. Th historical pregnancy rate obtained with fresh embryos transferred using the same technique and on the same farm where the comparison between NSAIDs was performed was 28.6% at 58 days post-transfer (Vivanco-Mackie et al. 2015 Reprod. Fertil. Dev. 27, 173 abst). Results suggest that there is no difference between tolfenamic acid and meloxicam in their effect on pregnancy rates in alpacas receiving fresh embryo transfers. Compared with historical data of nontreated recipients, results of the present experiment may indicate that the use of NSAIDs at the time of embryo transfer does not improve pregnancy rates in alpaca fresh embryo recipients. However, additional research studies with greater numbers of recipients and an untreated control group are necessary to confirm the preliminary results of the present study. The study was funded by the ‘INNOVATE PERU’ program of the Peruvian Government.

scholarly journals Effects of pelvic floor bioelectrical stimulation on frozen embryo transfer patients with thin endometrium

2019 ◽  
Vol 17 ◽  
pp. 205873921882286
Author(s):  
Bing Yuan ◽  
Hong Zheng ◽  
Minling Xu ◽  
Xiaoli Mu ◽  
Fengcai Huang
Keyword(s):  
Pelvic Floor ◽  
Embryo Transfer ◽  
Embryo Implantation ◽  
Implantation Rate ◽  
Frozen Embryo Transfer ◽  
Control Group ◽  
Observation Group ◽  
Thin Endometrium ◽  
Significant Difference ◽  
Artificial Cycle

This study was to observe the effects of pelvic floor bioelectrical stimulation on pregnancy outcome and serum estradiol (E2) and progesterone (P) levels in frozen embryo transfer patients with thin endometrium. 120 cases frozen embryo transfer patients with thin endometrium in our hospital from March 2016 to April 2017 were selected. These patients received artificial cycle replacement plan before embryo transfer. According to whether pelvic floor bioelectrical stimulation therapy was accepted, 120 cases of thin endometrial frozen embryo transfer were divided into control group and observation group. 50 cases of the control group received artificial cycle to prepare for embryo transplantation, while 70 cases of observation group received bioelectrical stimulation as intervention treatment on the basis of artificial cycle. The intima thickness, subintimal hemodynamic parameters, embryo implantation rate, and clinical pregnancy rate were compared between the two groups before and after treatment. There was no significant difference in endometrial thickness between the two groups on the 10th day of menstruation ( P > 0.05). The thickness of endometrium and the index of intima growth in the observation group were significantly higher than those in the control group ( P < 0.05). The pulsatility index, resistance index, and systolic and diastolic blood flow velocity ratio of subintimal blood flow in the observation group were significantly higher than those in the control group ( P < 0.05). Before treatment, there was no significant difference in serum E2 and P between the two groups ( P > 0.05). After treatment, the improvement of serum E2 and P in the observation group was significantly better than that of the control group ( P < 0.05). The embryo implantation rate (25.7%) in the observation group was significantly higher than that in the control group (17.0%) ( P < 0.05). The clinical pregnancy rate (47.1%) in the observation group was significantly higher than that in the control group (30%) ( P < 0.05). In conclusion, the intervention of pelvic floor bioelectrical stimulation can improve the blood perfusion of thin endometrium, improve the endometrial receptivity, increase the implantation rate of frozen embryo transfer in patients with thin endometrium, and improve the level of serum estradiol and progesterone.

The Effectiveness of a Program of Oral Sensory-Motor Therapy with the Severely and Profoundly Developmentally Disabled

1981 ◽  
Vol 1 (2) ◽  
pp. 147-160 ◽  
Author(s):  
Kenneth Ottenbacher ◽  
Ann Scoggins ◽  
Jamie Wayland
Keyword(s):  
Body Weight ◽  
Developmentally Disabled ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Feeding Patterns ◽  
Control Group Design ◽  
Oral Motor ◽  
Significant Difference ◽  
Post Hoc ◽  
And Control

The efficacy of a program of oral-motor therapy designed to facilitate feeding patterns and thus produce increases in body weight in the severely developmentally disabled was explored. Twenty severely and profoundly retarded subjects with neuromotor disorders participated in a pretest / posttest control group design. The experimental group received a 9-week program of oral therapy designed to normalize oral motor functions and reduce pathological oral reflexes. Analysis of covariance revealed no statistically significant difference in body weight gains between the experimental and control group over the treatment period. A post hoc power analysis was computed and revealed a power of approximately .35, indicating a degree of insensitivity in the experimental manipulations and statistical analysis and suggesting the possibility of a Type II experimental error. The need for continued research in this area to establish the effectiveness of sensory and motor facilitation procedures in developing feeding patterns in the severely and profoundly disabled is discussed.

scholarly journals Presence of different forms of compensatory behaviours among eating disordered patients

2010 ◽  
Vol 138 (5-6) ◽  
pp. 328-332
Author(s):  
Olga Kontic ◽  
Nadja Vasiljevic ◽  
Jagoda Jorga ◽  
Miroslava Jasovic-Gasic ◽  
Aneta Lakic ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Body Weight ◽  
Eating Disorder ◽  
Control Group ◽  
Excessive Exercise ◽  
Eating Disordered ◽  
Significant Difference ◽  
24 Hour Recall ◽  
And Control ◽  
Experimental Group

Introduction Eating disorders indicate unhealthy habits in nutrition and/or behaviour in the feeding and maintaining of body weight. The main characteristic of these diseases is changed behaviour in nutrition, either as an intentional restriction of food, namely extreme dieting or overeating, i.e. binge eating. Extreme dieting, skipping meals, self-induced vomiting, excessive exercise, and misuse of laxatives and diuretics for the purpose of maintaining or reducing body weight are the forms of compensatory behaviour. Objective The purpose of the present research was to determine the presence of different inappropriate compensatory behaviours among eating disordered patients. Methods The experimental group included 35 female eating disordered patients of 23.02?}3.46 years on average, with anorexia or bulimia nervosa. The control group consisted of 70 girls aged 23.1?}3.0 years on average. Each participant completed a '24-hour Recall Questionnaire' and the 'Eating Disorder Diagnostic Scale'. Results A high statistically significant difference existed in the presence of all compensatory behaviours in the experimental and control group, regarding vomiting (?2=40.6; p<0.001), misuse of laxatives and diuretics (?2=33.7; p<0.001), extreme dieting (?2=23.4; p<0.001) and excessive exercising (?2=27.1; p<0.001). Conclusion Eating disordered patients showed a significantly higher incidence of all evaluated forms of compensatory behaviour in comparison with the control group. This report confirms the presence of specific symptomatology of anorexia and bulimia patients. .

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

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