scholarly journals Seeking the origin of female germline stem cells in the mammalian ovary

Reproduction ◽  
2013 ◽  
Vol 146 (4) ◽  
pp. R125-R130 ◽  
Author(s):  
Massimo De Felici ◽  
Florencia Barrios
Keyword(s):  
Stem Cells ◽  
Scientific Community ◽  
Germline Stem Cells ◽  
Ongoing Debate ◽  
New Class ◽  
Experimental Approaches ◽  
Definition Of ◽  
Female Germline ◽  
Shed Light

The function of female germline stem cells (FGSCs, also called oogonial stem cells) in the adult mammalian ovary is currently debated in the scientific community. As the evidence to support or discard the possible crucial role of this new class of germ cells in mammals has been extensively discussed, in this review, we wonder which could be their origin. We will assume that FGSCs are present in the post-natal ovaries and speculate as to what origin and characteristics such cells could have. We believe that the definition of these features might shed light on future experimental approaches that could clarify the ongoing debate.

scholarly journals Characterization of female germline stem cells from adult mouse ovaries and the role of rapamycin on them

2018 ◽  
Vol 70 (2) ◽  
pp. 843-854 ◽  
Author(s):  
Hong Yang ◽  
Xi Yao ◽  
Furong Tang ◽  
Yudong Wei ◽  
Jinlian Hua ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adult Mouse ◽  
Germline Stem Cells ◽  
Female Germline

How Can Female Germline Stem Cells Contribute to the Physiological Neo-Oogenesis in Mammals and Why Menopause Occurs?

2010 ◽  
Vol 17 (4) ◽  
pp. 498-505 ◽  
Author(s):  
Antonin Bukovsky
Keyword(s):  
Stem Cells ◽  
Adult Mouse ◽  
Mammalian Species ◽  
Reproductive Period ◽  
Germline Stem Cells ◽  
Environmental Threats ◽  
Ovarian Stem Cells ◽  
Lower Vertebrates ◽  
Female Germline ◽  
Prevailing View

AbstractAt the beginning of the last century, reproductive biologists have discussed whether in mammalian species the fetal oocytes persist or are replaced by neo-oogenesis during adulthood. Currently the prevailing view is that neo-oogenesis is functional in lower vertebrates but not in mammalian species. However, contrary to the evolutionary rules, this suggests that females of lower vertebrates have a better opportunity to provide healthy offspring compared to mammals with oocytes subjected to environmental threats for up to several decades. During the last 15 years, a new effort has been made to determine whether the oocyte pool in adult mammals is renewed as well. Most recently, Ji Wu and colleagues reported a production of offspring from female germline stem cells derived from neonatal and adult mouse ovaries. This indicates that both neonatal and adult mouse ovaries carry stem cells capable of producing functional oocytes. However, it is unclear whether neo-oogenesis from ovarian somatic stem cells is physiologically involved in follicular renewal and why menopause occurs. Here we review observations that indicate an involvement of immunoregulation in physiological neo-oogenesis and follicular renewal from ovarian stem cells during the prime reproductive period and propose why menopause occurs in spite of persisting ovarian stem cells.

scholarly journals GSK3 inhibitor-BIO regulates proliferation of female germline stem cells from the postnatal mouse ovary

2012 ◽  
Vol 45 (4) ◽  
pp. 287-298 ◽  
Author(s):  
Y. Hu ◽  
Y. Bai ◽  
Z. Chu ◽  
J. Wang ◽  
L. Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Germline Stem Cells ◽  
Mouse Ovary ◽  
Female Germline ◽  
Gsk3 Inhibitor

scholarly journals Comparison of different in vitro differentiation conditions for murine female germline stem cells

2018 ◽  
Vol 52 (1) ◽  
pp. e12530 ◽  
Author(s):  
Kang Zou ◽  
Jian Wang ◽  
Haiwei Bi ◽  
Yabin Zhang ◽  
Xueli Tian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Germline Stem Cells ◽  
In Vitro Differentiation ◽  
Female Germline

scholarly journals Endocrine regulation of female germline stem cells in the fruit fly Drosophila melanogaster

2019 ◽  
Vol 31 ◽  
pp. 14-19 ◽  
Author(s):  
Yuto Yoshinari ◽  
Yoshitomo Kurogi ◽  
Tomotsune Ameku ◽  
Ryusuke Niwa
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Fruit Fly ◽  
Endocrine Regulation ◽  
Germline Stem Cells ◽  
Female Germline

An Objective Approach Toward Understanding Auditory Processing Disorder

2021 ◽  
pp. 1-6
Author(s):  
Akshay R. Maggu ◽  
Tobias Overath
Keyword(s):  
Clinical Practice ◽  
Auditory Processing ◽  
Test Battery ◽  
Domain Specificity ◽  
Auditory Processing Disorder ◽  
Theoretical Construct ◽  
Ongoing Debate ◽  
Current Definition ◽  
Definition Of ◽  
Shed Light

Purpose In the field of audiology, auditory processing disorder (APD) continues to be a topic of ongoing debate for clinicians and scientists alike, both in terms of theory and clinical practice. In the current viewpoint, we first lay out the main issues that are central to the controversy surrounding APD, and then suggest a framework toward their resolution. Method The current viewpoint is informed by reviewing existing studies in the field of APD to better understand the issues contributing to the controversies in APD. Results We found that, within the current definition of APD, the two main issues that make the APD diagnosis controversial are (a) comorbidity with other disorders and (b) the lack of domain specificity. These issues remain unresolved, especially with the use of the existing behavioral APD test batteries. In this viewpoint, we shed light on how they can be mitigated by implementing the administration of an objective, physiological test battery. Conclusions By administering an objective test battery, as proposed in this viewpoint, we believe that it will be possible to achieve a higher degree of specificity to the auditory domain that will not only contribute towards clinical practice but also contribute towards strengthening APD as a theoretical construct.

scholarly journals Production of Zebrafish Offspring from Cultured Female Germline Stem Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62660 ◽  
Author(s):  
Ten-Tsao Wong ◽  
Abraham Tesfamichael ◽  
Paul Collodi
Keyword(s):  
Stem Cells ◽  
Germline Stem Cells ◽  
Female Germline

scholarly journals Role of the Hedgehog Signaling Pathway in Regulating the Behavior of Germline Stem Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Shiqin Li ◽  
Meng Wang ◽  
Yanghui Chen ◽  
Wei Wang ◽  
Junying Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Adult Stem Cells ◽  
Reproductive Function ◽  
Future Research ◽  
Germline Stem Cells ◽  
Proliferation And Differentiation ◽  
Hh Signaling

Germline stem cells (GSCs) are adult stem cells that are responsible for the production of gametes and include spermatogonial stem cells (SSCs) and ovarian germline stem cells (OGSCs). GSCs are located in a specialized microenvironment in the gonads called the niche. Many recent studies have demonstrated that multiple signals in the niche jointly regulate the proliferation and differentiation of GSCs, which is of significance for reproductive function. Previous studies have demonstrated that the hedgehog (Hh) signaling pathway participates in the proliferation and differentiation of various stem cells, including GSCs in Drosophila and male mammals. Furthermore, the discovery of mammalian OGSCs challenged the traditional opinion that the number of primary follicles is fixed in postnatal mammals, which is of significance for the reproductive ability of female mammals and the treatment of diseases related to germ cells. Meanwhile, it still remains to be determined whether the Hh signaling pathway participates in the regulation of the behavior of OGSCs. Herein, we review the current research on the role of the Hh signaling pathway in mediating the behavior of GSCs. In addition, some suggestions for future research are proposed.

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