scholarly journals Effects of neonatal administration of the reversible goitrogen propylthiouracil on the testis interstitium in adult rats

Reproduction ◽  
1994 ◽  
Vol 100 (1) ◽  
pp. 85-92 ◽  
Author(s):  
S. M. L. C. Mendis-Handagama ◽  
O. P. Sharma
Keyword(s):  
Adult Rats ◽  
Neonatal Administration

ULTRAMORPHOMETRIC STUDIES OF THE ADRENAL CORTEX OF ADULT RATS AFTER NEONATAL ADMINISTRATION OF SEX STEROIDS

1976 ◽  
Vol 81 (2) ◽  
pp. 537-547 ◽  
Author(s):  
E. Mäusle ◽  
G. Fickinger
Keyword(s):  
Sex Steroids ◽  
Smooth Endoplasmic Reticulum ◽  
Zona Fasciculata ◽  
Sprague Dawley ◽  
Adult Rats ◽  
Sprague Dawley Rats ◽  
Neonatal Administration ◽  
The Individual ◽  
Increased Activity ◽  
Functional Reaction

ABSTRACT The outer zona fasciculata of 28 Sprague-Dawley rats, 8 weeks old, was studied by means of ultramorphometry. Four males and 4 females each received 1250 μg of testosterone proprionate (TP) or 300 μg oestradiol benzoate (OeB) on the second day of life. Four males and 4 females in oestrus or dioestrus served as controls. The controls showed both sex and cyclic differences: in comparison to the males, females displayed a finely dispersed lipoid pattern; enlargement of the nucleus and an increase in the amount of smooth endoplasmic reticulum (SER) indicated an increased stimulation of the cortex during oestrus. Neonatal administration of TP in females causes a distinct enlargement of cells with an increase in the volumes of nucleus, mitochondria, liposomes, SER and liposomes. The mitochondria and liposomes show a small-dispersed pattern of distribution. All these function-specific morphometric parameters point to an increased activity of the individual cell. The changes are less pronounced after OeB than after TP. In the male, neonatal administration of sex steroids results in an alteration of the sizes of the mitochondria and liposomes. The liposomes are distributed finely dispersed. At the same time there is an increase in the lipoid content. According to these parameters, fasciculata cells fulfil the morphological conditions that are a prerequisite for an elevated functional reaction. This change is more marked following OeB than TP. Sex dimorphism is preserved following neonatal application of sex steroids since the alterations are much more pronounced in females than in males.

scholarly journals Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats

2002 ◽  
Vol 60 (4) ◽  
pp. 928-931 ◽  
Author(s):  
Cristiano Mendes-da-Silva ◽  
Sandra Lopes de Souza ◽  
Jairza Maria Barreto-Medeiros ◽  
Sebastião Rogério de Freitas-Silva ◽  
Daniela Eugênia Costa Antunes ◽  
...  
Keyword(s):  
Forced Swim Test ◽  
Experimental Models ◽  
Control Group ◽  
Adult Rats ◽  
Depressive Behavior ◽  
Swim Test ◽  
Serotonergic Activity ◽  
Forced Swim ◽  
Neonatal Administration ◽  
The Brain

Serotonin plays a role at the pathophysiology of depression in humans and in experimental models. The present study investigated the depressive behavior and the weigh evolution in adult rats (60 days) treated from the 1st to the 21st postnatal day with fluoxetine, a selective serotonin reuptake inhibitor (10 mg/kg, sc, daily). The depressive behavior was induced by the forced swim test (FST). The animals were submitted to two sessions of FST: 1st session for 15 min and the 2nd session 24h later, for 5 min. During the 2nd session the Latency of the Attempt of Escape (LAE) and Behavioral Immobility (BI) were appraised. The Fluoxetine group when compared to the Control group, showed an increase in LAE and a decrease in BI. The neonatal administration of fluoxetine reduced the depressive behavior in adult rats, possibly by increase in the brain serotonergic activity. This alteration can be associated to process of neuroadaptation.

Neonatal administration of N-acetyl-l-aspartyl-l-glutamate induces early neurodegeneration in hippocampus and alters behaviour in young adult rats

2006 ◽  
Vol 48 (6-7) ◽  
pp. 515-522 ◽  
Author(s):  
Věra Bubeníková-Valešová ◽  
Vladimir J. Balcar ◽  
Hana Tejkalová ◽  
Miloš Langmeier ◽  
František Št’astný
Keyword(s):  
Young Adult ◽  
Adult Rats ◽  
Neonatal Administration

scholarly journals A single neonatal administration of soybean oil and/or tamoxifen affects permanently the testis histomorphology in adult rats.

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Alicia González González ◽  
Everardo González Padilla ◽  
Francisco Fierro Fierro ◽  
María de Lourdes Juárez Mosqueda ◽  
Juan José Pérez Rivero ◽  
...  
Keyword(s):  
Soybean Oil ◽  
Adult Rats ◽  
Neonatal Administration

scholarly journals A single neonatal administration of soybean oil and/or tamoxifen affects permanently the testis histomorphology in adult rats.

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Alicia González-González ◽  
Everardo González-Padilla ◽  
Francisco Fierro-Fierro ◽  
María De Lourdes Juárez-Mosqueda ◽  
Juan José Pérez-Rivero ◽  
...  
Keyword(s):  
Soybean Oil ◽  
Sexual Differentiation ◽  
Critical Period ◽  
Male Rats ◽  
Histological Evaluation ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Adult Rats ◽  
Testicular Weight ◽  
Neonatal Administration

The aim of this study was to determine the effect of tamoxifen (Tx) and its vehicle, soybean oil (SO), during the critical period of hypothalamic sexual differentiation in newborn male rats, regarding gonadal histomorphology during adulthood. The animals were randomly divided into 3 groups (n = 5 each). An hour after birth, one group was treated subcutaneously with 200 μg of Tx, using commercial SO (20 uL) as a vehicle; another group was treated with only 20 μL of SO; the control group received no treatment. All rats were weighed and sacrificed by cervical dislocation on day 90 post-treatment. Testicles were removed, weighed and processed for histological evaluation. The single administration of Tx and/or SO during the critical period of sexual differentiation of the hypothalamus permanently altered testicular histomorphology, spermatogenesis, and body weight in adulthood. Alterations included vacuolization and reduction in the number of spermatogonia and Sertoli cells. The administration of Tx reduced the testicular weight, the diameter and area of the seminiferous tubules, and the height of the germinal epithelium, and increased the intertubular space. Soybean oil by itself reduced the number of spermatocytes and spermatids more than Tx did. There was no effect on the number of Leydig cells. The possibility that soybean oil can act as an endocrine disruptor deserves greater attention and opens the possibility for the development of new methods of pest control.

Enhanced locomotor activity in adult rats with neonatal administration ofN-omega-nitro-L-arginine

Synapse ◽  
2006 ◽  
Vol 60 (3) ◽  
pp. 264-270 ◽  
Author(s):  
Alejandro Mejorada ◽  
Patricia Aguilar-Alonso ◽  
Bertha Alicia León-Chavez ◽  
Gonzalo Flores
Keyword(s):  
Locomotor Activity ◽  
Adult Rats ◽  
Neonatal Administration

EFFECT OF NEONATAL ADMINISTRATION OF STEROIDS OR GONADECTOMY UPON OESTRADIOL-INDUCED LUTEINIZING HORMONE RELEASE IN RATS OF BOTH SEXES

1980 ◽  
Vol 85 (1) ◽  
pp. 69-74 ◽  
Author(s):  
F. GOGAN ◽  
I. A. BEATTIE ◽  
M. HERY ◽  
E. LAPLANTE ◽  
C. KORDON
Keyword(s):  
Luteinizing Hormone ◽  
Sexual Differentiation ◽  
Female Rats ◽  
Male Rats ◽  
Ovariectomized Rats ◽  
Hormone Release ◽  
Adult Rats ◽  
Luteinizing Hormone Release ◽  
Neonatal Administration ◽  
Lh Secretion

SUMMARY Implantation of oestradiol into adult rats of both sexes induced different patterns of LH secretion depending on the time at which gonadectomy or testosterone injection were performed. Castration 2 h after birth allowed an LH peak to occur daily at 18.00 h, but its amplitude was lower than that of adult gonadectomized female rats treated with oestradiol. Castration 24 h after birth elicited two kinds of response; a circadian discharge of LH lower than that of male rats gonadectomized 2 h after birth or a steady low level of LH. The LH rhythmicity induced by implantation of oestradiol was not seen after castration at 8 weeks of age. Neonatal administration of testosterone to female rats prevented the LH peak induced by oestradiol that was seen in adult ovariectomized rats. Neonatal or adult ovariectomy did not interfere with the rhythmical response of LH after implantation of oestradiol. Thus, it is concluded that sexual differentiation of the hypothalamus is primarily of masculine origin.

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