scholarly journals Effect of surgery and efferent duct ligation on testicular blood flow and testicular steroidogenesis in the rat

Reproduction ◽  
1985 ◽  
Vol 73 (1) ◽  
pp. 191-196 ◽  
Author(s):  
J. M. Wang ◽  
C. H. Gu ◽  
L. Tao ◽  
X. L. Wu
Keyword(s):  
Blood Flow ◽  
Efferent Duct ◽  
Duct Ligation ◽  
Testicular Blood Flow ◽  
Testicular Steroidogenesis

Changes in testicular blood flow and testosterone production during aspermatogenesis after irradiation

1983 ◽  
Vol 98 (1) ◽  
pp. 35-46 ◽  
Author(s):  
J. Wang ◽  
K. A. A. Galil ◽  
B. P. Setchell
Keyword(s):  
Blood Flow ◽  
Leydig Cells ◽  
Capillary Permeability ◽  
Extracellular Fluid ◽  
Testis Weight ◽  
Γ Irradiation ◽  
Adult Rats ◽  
Efferent Duct ◽  
Duct Ligation ◽  
Testicular Blood Flow

Exposure of the testes of anaesthetized adult rats to 527 rads of γ-irradiation caused testis weight to fall slowly at first and then more rapidly from 21 days afterwards, reaching a minimum at 52 days, when spermatogenesis was severely disrupted. The weights of the accessory organs and the concentrations of testosterone in peripheral blood were slightly reduced; the concentrations in blood from the testicular veins were lower than control at shorter intervals after irradiation, but at later times tended to be similar or greater than control. Testicular blood flow per testis followed testis weight closely, and as a result the production of testosterone by the smaller testes (calculated as the product of plasma flow and the veno–arterial difference in testosterone concentration) was markedly reduced especially when the rats had been stimulated with human chorionic gonadotrophin (hCG). Serum FSH and LH rose appreciably as testis weight fell but there was a proportionately greater rise in FSH than LH, in comparison with surgically castrated animals. Increased amounts of extratubular, extracellular fluid were found in the aspermatogenic testes, but injection of hCG still caused increases in capillary permeability and the amount of fluid in the testis. These results indicate that during aspermatogenesis following irradiation (as with heat and efferent duct ligation) the capacity of the testes to secrete testosterone is severely limited by decreased testicular blood flow, not by the ability of the Leydig cells to release testosterone into their immediate environment.

scholarly journals Limitations Imposed by Testicular Blood Flow on the Function of Leydig Cells in Rats in vivo

1983 ◽  
Vol 36 (3) ◽  
pp. 285 ◽  
Author(s):  
BP Setchell ◽  
KAA Galil
Keyword(s):  
Blood Flow ◽  
Leydig Cells ◽  
Venous Blood ◽  
Testis Weight ◽  
Single Exposure ◽  
Efferent Duct ◽  
Efferent Ducts ◽  
Duct Ligation ◽  
Testicular Blood Flow

Testis blood flow per testis closely follows testis weight in rats made aspermatogenic by a single exposure of the testis to 43�C for 30 min or 500 rad (5 Gy) of irradiation from a caesium source, or following ligation of the efferent ducts. Aspermatogenesis following these treatments was associated with only minor changes in the concentrations of testosterone in peripheral blood before stimulation with human chorionic gonadotrophin (hCG), and a reduced responsiveness to hCG when testis weight had fallen after heating. The concentrations of testosterone in testicular venous blood was normal or above normal during aspermatogenesis resulting from heat or irradiation, and only slightly reduced following efferent duct ligation.

Acute scrotum and testicular blood flow

Choonpa Igaku ◽  
2014 ◽  
Vol 41 (6) ◽  
pp. 801-810
Author(s):  
Kimihiko MORIYA
Keyword(s):  
Blood Flow ◽  
Acute Scrotum ◽  
Testicular Blood Flow

scholarly journals Testicular microvascular flow is altered in Klinefelter syndrome and predicts circulating testosterone

2021 ◽  
Author(s):  
Francesco Carlomagno ◽  
Carlotta Pozza ◽  
Marta Tenuta ◽  
Riccardo Pofi ◽  
Luigi Tarani ◽  
...  
Keyword(s):  
Blood Flow ◽  
Klinefelter Syndrome ◽  
Mean Transit Time ◽  
Venous Blood ◽  
Experimental Studies ◽  
Principal Component ◽  
Endocrine Function ◽  
Venous Blood Flow ◽  
Testicular Blood Flow

ABSTRACTContextExperimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS.ObjectiveTo analyze the testicular microcirculation in KS by contrast-enhanced ultrasonography (CEUS) and correlate vascular parameters with endocrine function.Design and SettingProspective study. University Settings.Patients51 testicular scans, 17 testes from 10 T-naïve subjects with KS and 34 testes from age-matched eugonadal men (CNT) who underwent CEUS for incidental nonpalpable testicular lesions.Main OutcomesCEUS kinetic parameters.ResultsCEUS revealed slower testicular perfusion kinetics in subjects with KS than in age-matched CNT. Specifically, the wash-in time (Tin, p = 0.008), mean transit time (MTT, p = 0.008), time to peak (TTP, p < 0.001), and washout time (Tout 50%, p = 0.008) were all prolonged. Faster testicular blood flow was associated with higher total T levels. Principal component analysis and multiple linear regression analyses confirmed the findings, and supported a role for reduced venous blood flow as independent predictor of total T levels.ConclusionsTesticular venous blood flow is altered in KS and independently predicts T peripheral release.

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