Exposure to perfluoroalkyl substances during fetal life and pubertal development in boys and girls from the Danish National Birth Cohort

2019 ◽  
Author(s):  
Ernst A ◽  
Brix N ◽  
Lauridsen LLB ◽  
Olsen J ◽  
Parner ET ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Pubertal Development ◽  
Perfluoroalkyl Substances ◽  
Fetal Life ◽  
Danish National Birth Cohort

scholarly journals Exposure to Perfluoroalkyl Substances during Fetal Life and Pubertal Development in Boys and Girls from the Danish National Birth Cohort

2019 ◽  
Vol 127 (1) ◽  
pp. 017004 ◽  
Author(s):  
Andreas Ernst ◽  
Nis Brix ◽  
Lea Lykke Braskhøj Lauridsen ◽  
Jørn Olsen ◽  
Erik Thorup Parner ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Pubertal Development ◽  
Perfluoroalkyl Substances ◽  
Fetal Life ◽  
Danish National Birth Cohort

scholarly journals Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort

2018 ◽  
Vol 126 (6) ◽  
pp. 067004 ◽  
Author(s):  
Zeyan Liew ◽  
Beate Ritz ◽  
Cathrine Carlsen Bach ◽  
Robert F. Asarnow ◽  
Bodil Hammer Bech ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Prenatal Exposure ◽  
Perfluoroalkyl Substances ◽  
Danish National Birth Cohort ◽  
Iq Scores

scholarly journals Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort

2018 ◽  
Vol 15 (9) ◽  
pp. 1832 ◽  
Author(s):  
Qi Meng ◽  
Kosuke Inoue ◽  
Beate Ritz ◽  
Jørn Olsen ◽  
Zeyan Liew
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Birth Cohort ◽  
Birth Outcomes ◽  
Statistical Power ◽  
Plasma Concentrations ◽  
Fold Increase ◽  
Perfluoroalkyl Substances ◽  
Danish National Birth Cohort

Perfluoroalkyl substances (PFASs) are widespread industrial pollutants that are extremely persistent in the environment. A previous study in the Danish National Birth Cohort (DNBC) found prenatal perfluorooctanoate (PFOA) exposure was associated with decreased birth weight, but had insufficient statistical power to evaluate adverse birth outcomes. Here, we conducted additional analyses in three samples originating from the DNBC for 3535 mothers and infant pairs to evaluate associations between prenatal PFASs exposures and low birth weight and preterm birth. Maternal plasma concentrations were measured for six types of PFASs in early pregnancy. Several PFASs were associated with a reduction in birth weight and gestational age. We estimated a nearly 2-fold increase in risks of preterm birth for the higher quartiles of PFOA and perflourooctanesulfonate (PFOS) exposure. In spline models, risk of preterm birth was increased for perfluorononanoic acid (PFNA), perfluoroheptane sulfonate (PFHpS) and perfluorodecanoic acid (PFDA) in higher exposure ranges. We also observed some elevated risks for low birth weight but these estimates were less precise. Our findings strengthen the evidence that in-utero PFASs exposures affect fetal growth. Future studies are needed to evaluate whether these associations persist with the decline of PFOA and PFOS in populations and should also investigate newer types of fluorinated compounds introduced more recently.

scholarly journals Perfluoroalkyl Substances and Maternal Thyroid Hormones in Early Pregnancy; Findings in the Danish National Birth Cohort

2019 ◽  
Vol 127 (11) ◽  
pp. 117002 ◽  
Author(s):  
Kosuke Inoue ◽  
Beate Ritz ◽  
Stine Linding Andersen ◽  
Cecilia Høst Ramlau-Hansen ◽  
Birgit Bjerre Høyer ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Birth Cohort ◽  
Early Pregnancy ◽  
Perfluoroalkyl Substances ◽  
Danish National Birth Cohort ◽  
Maternal Thyroid

Maternal Perfluoroalkyl Substances Levels in Pregnancy and Child IQ: a Danish National Birth Cohort Study.

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Zeyan Liew* ◽  
Beate Ritz ◽  
Bodil Hammer Bech ◽  
Ellen Nohr ◽  
Rossana Bossi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Perfluoroalkyl Substances ◽  
Birth Cohort Study ◽  
Danish National Birth Cohort ◽  
In Pregnancy
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