scholarly journals Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis

2018 ◽  
Vol 7 (11) ◽  
pp. 1158-1167 ◽  
Author(s):  
Mírian Romitti ◽  
Vitor C Fabris ◽  
Patricia K Ziegelmann ◽  
Ana Luiza Maia ◽  
Poli Mara Spritzer
Keyword(s):  
Systematic Review ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Reference Group ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Reproductive Age ◽  
Cross Sectional ◽  
Autoimmune Thyroid

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder affecting women of reproductive age. PCOS has been associated with distinct metabolic and cardiovascular diseases and with autoimmune conditions, predominantly autoimmune thyroid disease (AITD). AITD has been reported in 18–40% of PCOS women, depending on PCOS diagnostic criteria and ethnicity. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding the likelihood of women with PCOS also having AITD in comparison to a reference group of non-PCOS women. We systematically searched EMBASE and MEDLINE for non-interventional case control, cross-sectional or cohort studies published until August 2017. The Ottawa–Newcastle Scale was used to assess the methodological quality of studies. Statistical meta-analysis was performed with R. Thirteen studies were selected for the present analysis, including 1210 women diagnosed with PCOS and 987 healthy controls. AITD was observed in 26.03 and 9.72% of PCOS and control groups respectively. A significant association was detected between PCOS and chance of AITD (OR = 3.27, 95% CI 2.32–4.63). Notably, after geographical stratification, the higher risk of AITD in PCOS women persisted for Asians (OR = 4.56, 95% CI 2.47–8.43), Europeans (OR = 3.27, 95% CI 2.07–5.15) and South Americans (OR = 1.86, 95% CI 1.05–3.29). AIDT is a frequent condition in PCOS patients and might affect thyroid function. Thus, screening for thyroid function and thyroid-specific autoantibodies should be considered in patients with PCOS even in the absence of overt symptoms. This systematic review and meta-analysis is registered in PROSPERO under number CRD42017079676.

scholarly journals The association of autoimmune thyroid disease (AITD) with psoriatic disease: a prospective cohort study, systematic review and meta-analysis

2017 ◽  
Vol 177 (4) ◽  
pp. 347-359 ◽  
Author(s):  
Samer R Khan ◽  
Arjola Bano ◽  
Marlies Wakkee ◽  
Tim I M Korevaar ◽  
Oscar H Franco ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Thyroid Disease ◽  
Prospective Cohort ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid ◽  
Psoriatic Disease ◽  
Disease Definition

ObjectiveAutoimmune thyroid disease (AITD) and psoriatic disease share auto-immunological components. Few studies have investigated the link between both, yielding inconclusive results.DesignWe assessed the association of AITD with psoriatic disease in a prospective cohort study and performed a systematic review and meta-analysis.Methods8214 participants of the Rotterdam Study (RS) with thyroid peroxidase antibodies (TPO-Abs), thyroid-stimulating hormone (TSH) and/or free thyroxine (FT4) measurements and information on psoriatic disease were included. We performed logistic and Cox regression analyses and a systematic literature search in several electronic databases on AITD and psoriatic disease. We pooled odds ratios (ORs) of included studies using the Mantel-Haenszel method, while adding RS data on prevalent psoriatic disease.ResultsWithin the RS, we found no association between TPO-Ab positivity and psoriatic disease. There was a positive trend between TSH and prevalent psoriatic disease, and between FT4 and incident psoriatic disease, although not significant. Out of 1850 articles identified, seven were included in the systematic review and four in the meta-analysis. The risk of psoriatic disease (pooled OR) was 1.71 (confidence interval (CI): 1.27–2.31) for TPO-Ab positivity, 1.25 (CI: 1.14–1.37) for AITD and 1.34 (CI: 1.16–1.54) respectively, and 1.17 (CI: 1.03–1.32) for hypothyroidism and hyperthyroidism.ConclusionsOur meta-analysis suggests that TPO-Ab positivity, hypothyroidism and hyperthyroidism might be associated with prevalent psoriatic disease. However, there are only few studies with large heterogeneity regarding psoriatic disease definition and indication of publication bias. Additional prospective data are needed to assess the association of AITD with incident psoriatic disease.

scholarly journals Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Boshen Gong ◽  
Chuyuan Wang ◽  
Fanrui Meng ◽  
Haoyu Wang ◽  
Bo Song ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gut Microbiota ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Alpha Diversity ◽  
Microbiota Composition ◽  
Autoimmune Thyroid ◽  
The Family ◽  
Gut Microbiota Composition

BackgroundAutoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Growing attention has been paid toward the field of gut microbiota over the last few decades. Several recent studies have found that gut microbiota composition in patients with AITD has altered, but no studies have conducted systematic reviews on the association between gut microbiota and ATID.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane databases without language restrictions and conducted a systematic review and meta-analysis of eight studies, including 196 patients with AITD.ResultsThe meta-analysis showed that the alpha diversity and abundance of certain gut microbiota were changed in patients with AITD compared to the controls. Chao1,the index of the microflora richness, was increased in the Hashimoto’s thyroiditis group compared to controls (SMD, 0.68, 95%CI: 0.16 to 1.20), while it was decreased in the Graves’ disease group (SMD, -0.87, 95%CI: -1.46 to -0.28). In addition, we found that some beneficial bacteria like Bifidobacterium and Lactobacillus were decreased in the AITD group, and harmful microbiota like Bacteroides fragilis was significantly increased compared with the controls. Furthermore, the percentage of relevant abundance of other commensal bacteria such as Bacteroidetes, Bacteroides, and Lachnospiraceae was increased compared with the controls.ConclusionsThis meta-analysis indicates an association between AITD and alteration of microbiota composition at the family, genus, and species levels.Systematic Review RegistrationPROSPERO, identifier CRD42021251557.

scholarly journals Dietary interventions for the treatment and management of autoimmune thyroid disease: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Jorge Correia ◽  
Hafsa Meraj ◽  
Maaz Ahmad ◽  
Marroquin Ramirez Lucia Mariela ◽  
Corral Laura Gómez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Dietary Interventions ◽  
Autoimmune Thyroid

scholarly journals Prevalence of latent and overt polyautoimmunity in autoimmune thyroid disease: A systematic review and meta‐analysis

2020 ◽  
Vol 93 (4) ◽  
pp. 375-389
Author(s):  
Alejandro Botello ◽  
María Herrán ◽  
Valentina Salcedo ◽  
Yhojan Rodríguez ◽  
Juan‐Manuel Anaya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid

scholarly journals “Small Thyroid Gland” in Reproductive Women without Autoimmune Thyroid Disease—Ultrasonographic Evaluation as a Useful Screening Tool for Hypothyroidism

2021 ◽  
Vol 10 (9) ◽  
pp. 1828
Author(s):  
Justyna Milczarek-Banach ◽  
Piotr Miśkiewicz
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Predictive Factor ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Volume ◽  
Childbearing Age ◽  
Cross Sectional ◽  
Autoimmune Thyroid ◽  
Tsh Levels

Proper thyroid function is important for women of childbearing age, as hypothyroidism affects fertility, pregnancy and offspring. The upper reference limit for thyrotropin (TSH) in pregnancy was defined as <2.5 mU/L in the first trimester. Recommendations include either universal screening of TSH before pregnancy, or identifying individuals at “high risk” for thyroid illness. “Small thyroid gland” not associated with autoimmune thyroid disease (AITD) seems to be a reason for hypothyroidism and probably should be included in target case finding procedure before pregnancy. The purpose of this cross-sectional study was to analyze relationships between the thyroid volume and its function, and to determine the thyroid volume as a predictive factor for TSH levels above 2.5 µIU/mL in reproductive women without AITD. We included 151 women without AITD, and aged 18–40. Blood and urine samples were analyzed for parameters of thyroid function. Ultrasound examination of the thyroid was performed. The thyroid volume was negatively correlated with TSH. Women with a thyroid volume in the 1st quartile for the study population presented higher TSH levels versus women in the 4th quartile (p = 0.0132). A thyroid volume cut-off point of 9 mL was the predictive factor for TSH levels above 2.5 µIU/mL (p = 0.0037).

Association between thyroglobulin polymorphisms and autoimmune thyroid disease: a systematic review and meta-analysis of case–control studies

2018 ◽  
Vol 20 (6) ◽  
pp. 484-492 ◽  
Author(s):  
Ming-Liang Zhang ◽  
Dong-ming Zhang ◽  
Cai-E. Wang ◽  
Xiao-Long Chen ◽  
Fang-Zhou Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Autoimmune Thyroid

Rheumatic associations of autoimmune thyroid disease: a systematic review

2019 ◽  
Vol 38 (7) ◽  
pp. 1801-1809 ◽  
Author(s):  
Clement E. Tagoe ◽  
Tejas Sheth ◽  
Eugeniya Golub ◽  
Karen Sorensen
Keyword(s):  
Systematic Review ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid

Thyroid Function in Patients with Rheumatic Heart Disease

1985 ◽  
Vol 30 (1) ◽  
pp. 23-24
Author(s):  
M. D. Macleod
Keyword(s):  
Heart Disease ◽  
Rheumatic Heart Disease ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Normal Population ◽  
Autoimmune Thyroid ◽  
Cardiology Clinic ◽  
Rheumatic Heart

Thyroid function was assessed in 94 patients with rheumatic heart disease presenting consecutively to a cardiology clinic. Despite previous reports of an association with autoimmune thyroid disease, abnormal thyroid function occurred no more commonly in this group than would be anticipated in a normal population.

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