scholarly journals Prevalence of latent and overt polyautoimmunity in autoimmune thyroid disease: A systematic review and meta‐analysis

2020 ◽  
Vol 93 (4) ◽  
pp. 375-389
Author(s):  
Alejandro Botello ◽  
María Herrán ◽  
Valentina Salcedo ◽  
Yhojan Rodríguez ◽  
Juan‐Manuel Anaya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid

scholarly journals The association of autoimmune thyroid disease (AITD) with psoriatic disease: a prospective cohort study, systematic review and meta-analysis

2017 ◽  
Vol 177 (4) ◽  
pp. 347-359 ◽  
Author(s):  
Samer R Khan ◽  
Arjola Bano ◽  
Marlies Wakkee ◽  
Tim I M Korevaar ◽  
Oscar H Franco ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Thyroid Disease ◽  
Prospective Cohort ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid ◽  
Psoriatic Disease ◽  
Disease Definition

ObjectiveAutoimmune thyroid disease (AITD) and psoriatic disease share auto-immunological components. Few studies have investigated the link between both, yielding inconclusive results.DesignWe assessed the association of AITD with psoriatic disease in a prospective cohort study and performed a systematic review and meta-analysis.Methods8214 participants of the Rotterdam Study (RS) with thyroid peroxidase antibodies (TPO-Abs), thyroid-stimulating hormone (TSH) and/or free thyroxine (FT4) measurements and information on psoriatic disease were included. We performed logistic and Cox regression analyses and a systematic literature search in several electronic databases on AITD and psoriatic disease. We pooled odds ratios (ORs) of included studies using the Mantel-Haenszel method, while adding RS data on prevalent psoriatic disease.ResultsWithin the RS, we found no association between TPO-Ab positivity and psoriatic disease. There was a positive trend between TSH and prevalent psoriatic disease, and between FT4 and incident psoriatic disease, although not significant. Out of 1850 articles identified, seven were included in the systematic review and four in the meta-analysis. The risk of psoriatic disease (pooled OR) was 1.71 (confidence interval (CI): 1.27–2.31) for TPO-Ab positivity, 1.25 (CI: 1.14–1.37) for AITD and 1.34 (CI: 1.16–1.54) respectively, and 1.17 (CI: 1.03–1.32) for hypothyroidism and hyperthyroidism.ConclusionsOur meta-analysis suggests that TPO-Ab positivity, hypothyroidism and hyperthyroidism might be associated with prevalent psoriatic disease. However, there are only few studies with large heterogeneity regarding psoriatic disease definition and indication of publication bias. Additional prospective data are needed to assess the association of AITD with incident psoriatic disease.

scholarly journals Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis

2018 ◽  
Vol 7 (11) ◽  
pp. 1158-1167 ◽  
Author(s):  
Mírian Romitti ◽  
Vitor C Fabris ◽  
Patricia K Ziegelmann ◽  
Ana Luiza Maia ◽  
Poli Mara Spritzer
Keyword(s):  
Systematic Review ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Reference Group ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Reproductive Age ◽  
Cross Sectional ◽  
Autoimmune Thyroid

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder affecting women of reproductive age. PCOS has been associated with distinct metabolic and cardiovascular diseases and with autoimmune conditions, predominantly autoimmune thyroid disease (AITD). AITD has been reported in 18–40% of PCOS women, depending on PCOS diagnostic criteria and ethnicity. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding the likelihood of women with PCOS also having AITD in comparison to a reference group of non-PCOS women. We systematically searched EMBASE and MEDLINE for non-interventional case control, cross-sectional or cohort studies published until August 2017. The Ottawa–Newcastle Scale was used to assess the methodological quality of studies. Statistical meta-analysis was performed with R. Thirteen studies were selected for the present analysis, including 1210 women diagnosed with PCOS and 987 healthy controls. AITD was observed in 26.03 and 9.72% of PCOS and control groups respectively. A significant association was detected between PCOS and chance of AITD (OR = 3.27, 95% CI 2.32–4.63). Notably, after geographical stratification, the higher risk of AITD in PCOS women persisted for Asians (OR = 4.56, 95% CI 2.47–8.43), Europeans (OR = 3.27, 95% CI 2.07–5.15) and South Americans (OR = 1.86, 95% CI 1.05–3.29). AIDT is a frequent condition in PCOS patients and might affect thyroid function. Thus, screening for thyroid function and thyroid-specific autoantibodies should be considered in patients with PCOS even in the absence of overt symptoms. This systematic review and meta-analysis is registered in PROSPERO under number CRD42017079676.

scholarly journals Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Boshen Gong ◽  
Chuyuan Wang ◽  
Fanrui Meng ◽  
Haoyu Wang ◽  
Bo Song ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gut Microbiota ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Alpha Diversity ◽  
Microbiota Composition ◽  
Autoimmune Thyroid ◽  
The Family ◽  
Gut Microbiota Composition

BackgroundAutoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Growing attention has been paid toward the field of gut microbiota over the last few decades. Several recent studies have found that gut microbiota composition in patients with AITD has altered, but no studies have conducted systematic reviews on the association between gut microbiota and ATID.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane databases without language restrictions and conducted a systematic review and meta-analysis of eight studies, including 196 patients with AITD.ResultsThe meta-analysis showed that the alpha diversity and abundance of certain gut microbiota were changed in patients with AITD compared to the controls. Chao1,the index of the microflora richness, was increased in the Hashimoto’s thyroiditis group compared to controls (SMD, 0.68, 95%CI: 0.16 to 1.20), while it was decreased in the Graves’ disease group (SMD, -0.87, 95%CI: -1.46 to -0.28). In addition, we found that some beneficial bacteria like Bifidobacterium and Lactobacillus were decreased in the AITD group, and harmful microbiota like Bacteroides fragilis was significantly increased compared with the controls. Furthermore, the percentage of relevant abundance of other commensal bacteria such as Bacteroidetes, Bacteroides, and Lachnospiraceae was increased compared with the controls.ConclusionsThis meta-analysis indicates an association between AITD and alteration of microbiota composition at the family, genus, and species levels.Systematic Review RegistrationPROSPERO, identifier CRD42021251557.

scholarly journals Dietary interventions for the treatment and management of autoimmune thyroid disease: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Jorge Correia ◽  
Hafsa Meraj ◽  
Maaz Ahmad ◽  
Marroquin Ramirez Lucia Mariela ◽  
Corral Laura Gómez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Dietary Interventions ◽  
Autoimmune Thyroid

Association between thyroglobulin polymorphisms and autoimmune thyroid disease: a systematic review and meta-analysis of case–control studies

2018 ◽  
Vol 20 (6) ◽  
pp. 484-492 ◽  
Author(s):  
Ming-Liang Zhang ◽  
Dong-ming Zhang ◽  
Cai-E. Wang ◽  
Xiao-Long Chen ◽  
Fang-Zhou Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Autoimmune Thyroid

Rheumatic associations of autoimmune thyroid disease: a systematic review

2019 ◽  
Vol 38 (7) ◽  
pp. 1801-1809 ◽  
Author(s):  
Clement E. Tagoe ◽  
Tejas Sheth ◽  
Eugeniya Golub ◽  
Karen Sorensen
Keyword(s):  
Systematic Review ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid

scholarly journals Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Xue-Ren Gao ◽  
Yong-Guo Yu
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid ◽  
Asian Populations ◽  
Increased Risk ◽  
African Populations ◽  
Reduced Risk

The association between vitamin D receptor (VDR) polymorphisms (rs731236, rs1544410, rs2228570, and rs7975232) and the risk of autoimmune thyroid disease (AITD) had been investigated in previous studies. However, the results of these studies remained controversial. Thus, a meta-analysis was performed to derive a more precise conclusion. All related articles were systematically searched by PubMed, Embase, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association. The overall results indicated thatVDRrs731236 and rs2228570 polymorphisms were significantly associated with a reduced risk of AITD. However, a stratification analysis based on clinical types showed thatVDRrs731236 and rs2228570 polymorphisms were associated only with a reduced risk of HT. A stratification analysis by ethnicity showed thatVDRrs731236 polymorphism was significantly associated with a reduced risk of AITD in Asian and African populations.VDRrs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.VDRrs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.VDRrs7975232 polymorphism was significantly associated with an increased risk of AITD in African populations. In conclusion, the present study suggested thatVDRrs731236, rs1544410, rs2228570, and rs7975232 polymorphisms were significantly associated with AITD risk. However, more well-designed studies should be performed to verify the current results.

scholarly journals The proportion of peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease patients: a meta-analysis

2020 ◽  
Vol 67 (3) ◽  
pp. 317-326 ◽  
Author(s):  
Ziyi Chen ◽  
Yue Wang ◽  
Xi Ding ◽  
Meng Zhang ◽  
Mingqian He ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Thyroid Disease ◽  
Cd4 T Cells ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid

Prevalence of Celiac Disease in Patients with Autoimmune Thyroid Disease: A Meta-Analysis

Thyroid ◽  
2016 ◽  
Vol 26 (7) ◽  
pp. 880-890 ◽  
Author(s):  
Abhik Roy ◽  
Monika Laszkowska ◽  
Johan Sundström ◽  
Benjamin Lebwohl ◽  
Peter H.R. Green ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid
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