Limitations to anabolic stimulation of bone formation

2014 ◽  
Author(s):  
Roland Baron
Keyword(s):  
Bone Formation ◽  
Stimulation Of

scholarly journals The Role of BMP Signaling in Osteoclast Regulation

2021 ◽  
Vol 9 (3) ◽  
pp. 24
Author(s):  
Brian Heubel ◽  
Anja Nohe
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Proteins ◽  
Bone Diseases ◽  
Bmp Signaling ◽  
Bone Homeostasis ◽  
Direct Stimulation ◽  
Federal Drug Administration ◽  
Bmp Pathway ◽  
Stimulation Of

The osteogenic effects of Bone Morphogenetic Proteins (BMPs) were delineated in 1965 when Urist et al. showed that BMPs could induce ectopic bone formation. In subsequent decades, the effects of BMPs on bone formation and maintenance were established. BMPs induce proliferation in osteoprogenitor cells and increase mineralization activity in osteoblasts. The role of BMPs in bone homeostasis and repair led to the approval of BMP2 by the Federal Drug Administration (FDA) for anterior lumbar interbody fusion (ALIF) to increase the bone formation in the treated area. However, the use of BMP2 for treatment of degenerative bone diseases such as osteoporosis is still uncertain as patients treated with BMP2 results in the stimulation of not only osteoblast mineralization, but also osteoclast absorption, leading to early bone graft subsidence. The increase in absorption activity is the result of direct stimulation of osteoclasts by BMP2 working synergistically with the RANK signaling pathway. The dual effect of BMPs on bone resorption and mineralization highlights the essential role of BMP-signaling in bone homeostasis, making it a putative therapeutic target for diseases like osteoporosis. Before the BMP pathway can be utilized in the treatment of osteoporosis a better understanding of how BMP-signaling regulates osteoclasts must be established.

scholarly journals ApoE Gene Deficiency Enhances the Reduction of Bone Formation Induced by a High-Fat Diet Through the Stimulation of p53-Mediated Apoptosis in Osteoblastic Cells

2007 ◽  
Vol 22 (7) ◽  
pp. 1020-1030 ◽  
Author(s):  
Hideyuki Hirasawa ◽  
Shinya Tanaka ◽  
Akinori Sakai ◽  
Masato Tsutsui ◽  
Hiroaki Shimokawa ◽  
...  
Keyword(s):  
Bone Formation ◽  
High Fat Diet ◽  
Apoe Gene ◽  
Osteoblastic Cells ◽  
High Fat ◽  
Gene Deficiency ◽  
Stimulation Of

scholarly journals Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation

2002 ◽  
Vol 99 (7) ◽  
pp. 4580-4585 ◽  
Author(s):  
K. Yoshida ◽  
H. Oida ◽  
T. Kobayashi ◽  
T. Maruyama ◽  
M. Tanaka ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Formation ◽  
Receptor Activation ◽  
Prostaglandin E ◽  
Ep4 Receptor ◽  
Prevention Of Bone Loss ◽  
Stimulation Of

Implants for one-stage osteointegration with mechanobiological stimulation of bone formation

2021 ◽  
Vol 3 (3) ◽  
pp. 23-30
Author(s):  
V.P. Kuznetsov ◽  
A.A. Emanov ◽  
E.N. Gorbach ◽  
V.G. Gorgots
Keyword(s):  
Bone Formation ◽  
One Stage ◽  
Stimulation Of

Stimulation of bone formation by direct electrical current in an orthopedically expanded suture in the rat

2010 ◽  
Vol 40 (2) ◽  
pp. 106 ◽  
Author(s):  
Tancan Uysal ◽  
Mihri Amasyali ◽  
Huseyin Olmez ◽  
Yildirim Karslioglu ◽  
Omer Gunhan
Keyword(s):  
Bone Formation ◽  
Electrical Current ◽  
Direct Electrical Current ◽  
Stimulation Of

Bone changes due to pregnancy and lactation: influence of vitamin D status

1986 ◽  
Vol 251 (4) ◽  
pp. E400-E406 ◽  
Author(s):  
P. J. Marie ◽  
L. Cancela ◽  
N. Le Boulch ◽  
L. Miravet
Keyword(s):  
Vitamin D ◽  
Bone Resorption ◽  
Bone Formation ◽  
Trabecular Bone ◽  
Formation Rate ◽  
Vitamin D Status ◽  
Bone Formation Rate ◽  
Bone Calcium ◽  
Pregnancy And Lactation ◽  
Stimulation Of

The effects of pregnancy and lactation on endosteal bone formation and resorption were evaluated in vitamin D-depleted (-D) and vitamin D-repleted (+D) rats. Pregnancy induced a marked stimulation of osteoclastic bone resorption and of static and dynamic parameters of bone formation and mineralization. Bone resorption increased independently of vitamin D status and did not correlate with plasma 1,25-dihydroxyvitamin D3 [1,25(OH)2D] levels, but it was associated with increased plasma immunoreactive parathyroid hormone (iPTH) concentrations. Stimulation of the endosteal bone formation rate was mainly impaired in D-depleted rats, resulting in trabecular bone loss, which, in -D mother rats, was associated with decreased bone ash and total bone calcium. Lactation further stimulated bone resorption and reduced the trabecular bone volume; ash weight and bone calcium content were also decreased independently of the vitamin D status and changes in plasma iPTH levels. In presence of vitamin D, the bone formation rate increased fourfold during lactation but was unchanged in -D lactating rats. During lactation, vitamin D-depleted rats lost twofold more calcified bone than +D rats because of impaired mineralization. Thus, the present study shows that both the endosteal bone resorption and formation are stimulated by pregnancy and lactation and that vitamin D is required for normal bone mineralization during the reproductive period.

Ephrin-B stimulation of calvarial bone formation

2012 ◽  
Vol 241 (12) ◽  
pp. 1901-1910 ◽  
Author(s):  
M. Douglas Benson ◽  
Lynne A. Opperman ◽  
Jan Westerlund ◽  
Claudia R. Fernandez ◽  
Symone San Miguel ◽  
...  
Keyword(s):  
Bone Formation ◽  
Calvarial Bone ◽  
Stimulation Of

In vivo stimulation of bone formation by aluminum and oxygen plasma surface-modified magnesium implants

Biomaterials ◽  
2013 ◽  
Vol 34 (38) ◽  
pp. 9863-9876 ◽  
Author(s):  
Hoi Man Wong ◽  
Ying Zhao ◽  
Vivian Tam ◽  
Shuilin Wu ◽  
Paul K. Chu ◽  
...  
Keyword(s):  
Bone Formation ◽  
Oxygen Plasma ◽  
Plasma Surface ◽  
Surface Modified ◽  
Stimulation Of
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