Ephrin-B stimulation of calvarial bone formation

2012 ◽  
Vol 241 (12) ◽  
pp. 1901-1910 ◽  
Author(s):  
M. Douglas Benson ◽  
Lynne A. Opperman ◽  
Jan Westerlund ◽  
Claudia R. Fernandez ◽  
Symone San Miguel ◽  
...  
Keyword(s):  
Bone Formation ◽  
Calvarial Bone ◽  
Stimulation Of

scholarly journals The Role of BMP Signaling in Osteoclast Regulation

2021 ◽  
Vol 9 (3) ◽  
pp. 24
Author(s):  
Brian Heubel ◽  
Anja Nohe
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Proteins ◽  
Bone Diseases ◽  
Bmp Signaling ◽  
Bone Homeostasis ◽  
Direct Stimulation ◽  
Federal Drug Administration ◽  
Bmp Pathway ◽  
Stimulation Of

The osteogenic effects of Bone Morphogenetic Proteins (BMPs) were delineated in 1965 when Urist et al. showed that BMPs could induce ectopic bone formation. In subsequent decades, the effects of BMPs on bone formation and maintenance were established. BMPs induce proliferation in osteoprogenitor cells and increase mineralization activity in osteoblasts. The role of BMPs in bone homeostasis and repair led to the approval of BMP2 by the Federal Drug Administration (FDA) for anterior lumbar interbody fusion (ALIF) to increase the bone formation in the treated area. However, the use of BMP2 for treatment of degenerative bone diseases such as osteoporosis is still uncertain as patients treated with BMP2 results in the stimulation of not only osteoblast mineralization, but also osteoclast absorption, leading to early bone graft subsidence. The increase in absorption activity is the result of direct stimulation of osteoclasts by BMP2 working synergistically with the RANK signaling pathway. The dual effect of BMPs on bone resorption and mineralization highlights the essential role of BMP-signaling in bone homeostasis, making it a putative therapeutic target for diseases like osteoporosis. Before the BMP pathway can be utilized in the treatment of osteoporosis a better understanding of how BMP-signaling regulates osteoclasts must be established.

scholarly journals ApoE Gene Deficiency Enhances the Reduction of Bone Formation Induced by a High-Fat Diet Through the Stimulation of p53-Mediated Apoptosis in Osteoblastic Cells

2007 ◽  
Vol 22 (7) ◽  
pp. 1020-1030 ◽  
Author(s):  
Hideyuki Hirasawa ◽  
Shinya Tanaka ◽  
Akinori Sakai ◽  
Masato Tsutsui ◽  
Hiroaki Shimokawa ◽  
...  
Keyword(s):  
Bone Formation ◽  
High Fat Diet ◽  
Apoe Gene ◽  
Osteoblastic Cells ◽  
High Fat ◽  
Gene Deficiency ◽  
Stimulation Of

scholarly journals Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation

2002 ◽  
Vol 99 (7) ◽  
pp. 4580-4585 ◽  
Author(s):  
K. Yoshida ◽  
H. Oida ◽  
T. Kobayashi ◽  
T. Maruyama ◽  
M. Tanaka ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Formation ◽  
Receptor Activation ◽  
Prostaglandin E ◽  
Ep4 Receptor ◽  
Prevention Of Bone Loss ◽  
Stimulation Of

Implants for one-stage osteointegration with mechanobiological stimulation of bone formation

2021 ◽  
Vol 3 (3) ◽  
pp. 23-30
Author(s):  
V.P. Kuznetsov ◽  
A.A. Emanov ◽  
E.N. Gorbach ◽  
V.G. Gorgots
Keyword(s):  
Bone Formation ◽  
One Stage ◽  
Stimulation Of

Bone Formation Effect of HA/β-TCP Composite Powders in Rabbit Calvarial Bone Defects: Histologic Study

2007 ◽  
pp. 1331-1334
Author(s):  
Hyun Seon Jang ◽  
Kwang Ho Lee ◽  
Moon Jin Jeong ◽  
Joo Cheol Park ◽  
Heung Joong Kim ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Defects ◽  
Histologic Study ◽  
Composite Powders ◽  
Calvarial Bone

Behavior of Osteoclast Cells Response on Dicalcium Phosphate Dihydrate Layer-Coated β-Tricalcium Phosphate Granular

2020 ◽  
Vol 1010 ◽  
pp. 549-554
Author(s):  
Khairul Anuar Shariff ◽  
Mohamad Hafizi Abu Bakar ◽  
Arief Cahyanto
Keyword(s):  
Bone Formation ◽  
Dicalcium Phosphate ◽  
Phosphate Solution ◽  
Dicalcium Phosphate Dihydrate ◽  
New Bone Formation ◽  
Osteoblast Cells ◽  
Calvarial Bone ◽  
Phosphate Dihydrate ◽  
Trap Staining ◽  
Block Section

The aim of this study is to investigate the behavior of osteoclast cells response on dicalcium phosphate dihydrate (DCPD) layer-coated β-TCP granules. β-TCP granules with 300-600 μm were exposed to acidic calcium phosphate solution for 30 mins in order to get 10 mol% DCPD layer-coated β-TCP granular. DCPD free-coated β-TCP granular had used as control specimen. Both specimens were implant in 9 mm of rat calvarial bone defect for 4 weeks. After 4 weeks, the block section of rat calvarial containing specimen were removed for Tatrate-Resistance Acid Phosphatase (TRAP) analysis. Results of TRAP staining reveal that the number of osteoclast cells attached on 10 mol% layer-coated β-TCP granular is higher than DCPD free-coated β-TCP granular. Since remodeling of new bone formation involved simultaneous osteoclast and osteoblast cells response, therefore, the results obtained in this study indicated that the presence of DCPD layer-coated on β-TCP granular helps to improve osteoclast cells response that contribute in stimulating new bone formation.

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