Exome-chip meta-analysis identifies novel associations of coding variants in BSN and GLRA4 with lumbar spine BMD in 27 339 adults of European descent

2014 ◽  
Author(s):  
Karol Estrada ◽  
◽  
Douglas Kiel ◽  
Andre Uitterlinden ◽  
Fernando Rivadeneira ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Meta Analysis ◽  
European Descent ◽  
Coding Variants ◽  
Exome Chip ◽  
Novel Associations

scholarly journals Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

2019 ◽  
Vol 85 (11) ◽  
pp. 946-955 ◽  
Author(s):  
David M. Brazel ◽  
Yu Jiang ◽  
Jordan M. Hughey ◽  
Valérie Turcot ◽  
Xiaowei Zhan ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Genetic Architecture ◽  
Meta Analysis ◽  
Causal Variants ◽  
Coding Variants ◽  
Exome Chip

scholarly journals Pre-Procedural Lumbar Neuraxial Ultrasound—A Systematic Review of Randomized Controlled Trials and Meta-Analysis

Healthcare ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 479
Author(s):  
Tatiana Sidiropoulou ◽  
Kalliopi Christodoulaki ◽  
Charalampos Siristatidis
Keyword(s):  
Systematic Review ◽  
Lumbar Spine ◽  
Randomized Controlled Trials ◽  
Success Rate ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Technical Failure ◽  
Obese Patients ◽  
Randomized Controlled ◽  
Meta Analyses

A pre-procedural ultrasound of the lumbar spine is frequently used to facilitate neuraxial procedures. The aim of this review is to examine the evidence sustaining the utilization of pre-procedural neuraxial ultrasound compared to conventional methods. We perform a systematic review of randomized controlled trials with meta-analyses. We search the electronic databases Medline, Cochrane Central, Science Direct and Scopus up to 1 June 2019. We include trials comparing a pre-procedural lumbar spine ultrasound to a non-ultrasound-assisted method. The primary endpoints are technical failure rate, first-attempt success rate, number of needle redirections and procedure time. We retrieve 32 trials (3439 patients) comparing pre-procedural lumbar ultrasounds to palpations for neuraxial procedures in various clinical settings. Pre-procedural ultrasounds decrease the overall risk of technical failure (Risk Ratio (RR) 0.69 (99% CI, 0.43 to 1.10), p = 0.04) but not in obese and difficult spinal patients (RR 0.53, p = 0.06) and increase the first-attempt success rate (RR 1.5 (99% CI, 1.22 to 1.86), p < 0.0001, NNT = 5). In difficult spines and obese patients, the RR is 1.84 (99% CI, 1.44 to 2.3; p < 0.0001, NNT = 3). The number of needle redirections is lower with pre-procedural ultrasounds (SMD = −0.55 (99% CI, −0.81 to −0.29), p < 0.0001), as is the case in difficult spines and obese patients (SMD = −0.85 (99% CI, −1.08 to −0.61), p < 0.0001). No differences are observed in procedural times. Ιn conclusion, a pre-procedural ultrasound provides significant benefit in terms of technical failure, number of needle redirections and first attempt-success rate. Τhe effect of pre-procedural ultrasound scanning of the lumbar spine is more significant in a subgroup analysis of difficult spines and obese patients.

scholarly journals The Influence of Stretching the Hip Flexor Muscles on Performance Parameters. A Systematic Review with Meta-Analysis

2021 ◽  
Vol 18 (4) ◽  
pp. 1936
Author(s):  
Andreas Konrad ◽  
Richard Močnik ◽  
Sylvia Titze ◽  
Masatoshi Nakamura ◽  
Markus Tilp
Keyword(s):  
Systematic Review ◽  
Lumbar Spine ◽  
Positive Impact ◽  
Meta Analysis ◽  
Force Production ◽  
Performance Parameters ◽  
Plantar Flexors ◽  
Performance Change ◽  
Flexor Muscles ◽  
Hip Flexor

The hip flexor muscles are major contributors to lumbar spine stability. Tight hip flexors can lead to pain in the lumbar spine, and hence to an impairment in performance. Moreover, sedentary behavior is a common problem and a major contributor to restricted hip extension flexibility. Stretching can be a tool to reduce muscle tightness and to overcome the aforementioned problems. Therefore, the purpose of this systematic review with meta-analysis was to determine the effects of a single hip flexor stretching exercise on performance parameters. The online search was performed in the following three databases: PubMed, Scopus, and Web of Science. Eight studies were included in this review with a total of 165 subjects (male: 111; female 54). In contrast to other muscle groups (e.g., plantar flexors), where 120 s of stretching likely decreases force production, it seems that isolated hip flexor stretching of up to 120 s has no effect or even a positive impact on performance-related parameters. A comparison of the effects on performance between the three defined stretch durations (30–90 s; 120 s; 270–480 s) revealed a significantly different change in performance (p = 0.02) between the studies with the lowest hip flexor stretch duration (30–90 s; weighted mean performance change: −0.12%; CI (95%): −0.49 to 0.41) and the studies with the highest hip flexor stretch duration (270–480 s; performance change: −3.59%; CI (95%): −5.92 to −2.04). Meta-analysis revealed a significant (but trivial) impairment in the highest hip flexor stretch duration of 270–480 s (SMD effect size = −0.19; CI (95%) −0.379 to 0.000; Z = −1.959; p = 0.05; I2 = 0.62%), but not in the lowest stretch duration (30–90 s). This indicates a dose-response relationship in the hip flexor muscles. Although the evidence is based on a small number of studies, this information will be of great importance for both athletes and coaches.

Opportunistic CT screening of osteoporosis on thoracic and lumbar spine: a meta-analysis

2021 ◽  
Author(s):  
Yeqing Zhu ◽  
Natthaya Triphuridet ◽  
Rowena Yip ◽  
Betsy Becker ◽  
Yong Wang ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Meta Analysis ◽  
Ct Screening ◽  
Thoracic And Lumbar Spine

The Effect of Calcium or Calcium and Vitamin D Supplementation on Bone Mineral Density in Healthy Males: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 25 (5) ◽  
pp. 510-524 ◽  
Author(s):  
Leslie N. Silk ◽  
David A. Greene ◽  
Michael K. Baker
Keyword(s):  
Bone Mineral Density ◽  
Systematic Review ◽  
Vitamin D ◽  
Lumbar Spine ◽  
Calcium Supplementation ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Mineral Density ◽  
Total Body ◽  
Healthy Males

Research examining the preventative effects of calcium and vitamin D supplementation has focused on children and females, leaving the effects on male bone mineral density (BMD) largely unexplored. Thus, the aim of this systematic review and meta-analysis is to examine the efficacy of calcium supplementation, with or without vitamin D for improving BMD in healthy males. Medline, EMBASE, SPORTDiscus, Academic Search Complete, CINHAHL Plus and PubMed databases were searched for studies including healthy males which provided participants calcium supplementation with or without vitamin D and used changes to BMD as the primary outcome measure. Between trial standardized mean differences of percentage change from baseline in BMD of femoral neck, lumbar spine, total body and total hip sites were calculated. Nine studies were included in the systematic review with six references totaling 867 participants contributing to the meta-analysis. Significant pooled effects size (ES) for comparison between supplementation and control groups were found at all sites included in the meta-analysis. The largest effect was found in total body (ES = 0.644; 95% CI = 0.406–0.883; p < .001), followed by total hip (ES = 0.483, 95% CI= 0.255–0.711, p < .001), femoral neck (ES = 0.402, 95% CI = 0.233–0.570, p = .000) and lumbar spine (ES = 0.306, 95% CI = 0.173–0.440, p < .001). Limited evidence appears to support the use of calcium and vitamin D supplementation for improving BMD in older males. There is a need for high quality randomized controlled trials, especially in younger and middle-aged male cohorts and athletic populations to determine whether supplementation provides a preventative benefit.

F4-04-01: EXOME CHIP META-ANALYSIS OF ALZHEIMER'S DISEASE IN THE IGAP CONSORTIUM

2014 ◽  
Vol 10 ◽  
pp. P245-P245
Author(s):  
Sven J. van der Lee ◽  
Adam Naj ◽  
Cornelia van Duijn ◽  
Gerard D. Schellenberg ◽  
International Genomics of Alzheimer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Exome Chip
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