scholarly journals Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease

2017 ◽  
Vol 49 (12) ◽  
pp. 1722-1730 ◽  
Author(s):  
Xiangfeng Lu ◽  
◽  
Gina M Peloso ◽  
Dajiang J Liu ◽  
Ying Wu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Meta Analysis ◽  
East Asian ◽  
Lipid Levels ◽  
Artery Disease ◽  
Coding Variants ◽  
Exome Chip

scholarly journals Bivariate GWAS scan identifies six novel loci associated with lipid levels and coronary artery disease

2018 ◽  
Author(s):  
Katherine M. Siewert ◽  
Benjamin F. Voight
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Risk ◽  
Association Studies ◽  
Meta Analysis ◽  
Plasma Lipid ◽  
Genome Wide Association Studies ◽  
Lipid Levels ◽  
Genome Wide ◽  
Artery Disease

AbstractBackgroundPlasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independently of one another. Joint GWAS for two related phenotypes can lead to a higher-powered analysis to detect variants contributing to both traits.Methods and ResultsWe performed a bivariate GWAS to discover novel loci associated with heart disease, using a CAD Meta-Analysis (122,733 cases and 424,528 controls), and lipid traits, using data from the Global Lipid Genetics Consortium (188,577 subjects). We identified six previously unreported loci at genome-wide significance (P < 5 × 10−8), three which were associated with Triglycerides and CAD, two which were associated with LDL cholesterol and CAD, and one associated with Total Cholesterol and CAD. At several of our loci, the GWAS signals jointly localize with genetic variants associated with expression level changes for one or more neighboring genes, indicating that these loci may be affecting disease risk through regulatory activity.ConclusionsWe discovered six novel variants individually associated with both lipids and coronary artery disease.

Non-fasting samples for estimation of serum lipid levels in patients with coronary artery disease

2014 ◽  
Vol 3 (3) ◽  
pp. 206
Author(s):  
P Srilakshmi ◽  
MF Gopinath ◽  
MVijaya Bhaskar ◽  
K Rambabu ◽  
GSrinivasa Reddy
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Lipid ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Artery Disease
Sign in / Sign up

Export Citation Format

Share Document