Bisphosphonate treatment in non-ambulatory patients with spastic quadriplegic cerebral palsy and other neuromuscular disorders: effectiveness of pamidronate vs zoledronic acid

2013 ◽  
Author(s):  
Bowden Sasigarn ◽  
Jessup Ashley ◽  
Wang Wei ◽  
Mahan John
Keyword(s):  
Cerebral Palsy ◽  
Zoledronic Acid ◽  
Neuromuscular Disorders ◽  
Bisphosphonate Treatment ◽  
Ambulatory Patients

scholarly journals Muscle contracture and passive mechanics in cerebral palsy

2019 ◽  
Vol 126 (5) ◽  
pp. 1492-1501 ◽  
Author(s):  
Richard L. Lieber ◽  
Jan Fridén
Keyword(s):  
Extracellular Matrix ◽  
Cerebral Palsy ◽  
Satellite Cells ◽  
Neuromuscular Disorders ◽  
Light And Electron Microscopy ◽  
Cell Types ◽  
Underlying Mechanism ◽  
Muscle Stiffness ◽  
Muscle Satellite Cells ◽  
Cord Injury

Skeletal muscle contractures represent the permanent shortening of a muscle-tendon unit, resulting in loss of elasticity and, in extreme cases, joint deformation. They may result from cerebral palsy, spinal cord injury, stroke, muscular dystrophy, and other neuromuscular disorders. Contractures are the prototypic and most severe clinical presentation of increased passive mechanical muscle force in humans, often requiring surgical correction. Intraoperative experiments demonstrate that high muscle passive force is associated with sarcomeres that are abnormally stretched, although otherwise normal, with fewer sarcomeres in series. Furthermore, changes in the amount and arrangement of collagen in the extracellular matrix also increase muscle stiffness. Structural light and electron microscopy studies demonstrate that large bundles of collagen, referred to as perimysial cables, may be responsible for this increased stiffness and are regulated by interaction of a number of cell types within the extracellular matrix. Loss of muscle satellite cells may be related to changes in both sarcomeres and extracellular matrix. Future studies are required to determine the underlying mechanism for changes in muscle satellite cells and their relationship (if any) to contracture. A more complete understanding of this mechanism may lead to effective nonsurgical treatments to relieve and even prevent muscle contractures.

scholarly journals Long-term results of hip arthroplasty in ambulatory patients with cerebral palsy

2009 ◽  
Vol 34 (3) ◽  
pp. 335-339 ◽  
Author(s):  
Kerstin Schroeder ◽  
Christian Hauck ◽  
Bernd Wiedenhöfer ◽  
Frank Braatz ◽  
Peter R. Aldinger
Keyword(s):  
Cerebral Palsy ◽  
Hip Arthroplasty ◽  
Long Term Results ◽  
Ambulatory Patients

Osteonecrosis of the Jaw in Cancer After Treatment With Bisphosphonates: Incidence and Risk Factors

2005 ◽  
Vol 23 (34) ◽  
pp. 8580-8587 ◽  
Author(s):  
Aristotle Bamias ◽  
Efstathios Kastritis ◽  
Christina Bamia ◽  
Lia A. Moulopoulos ◽  
Ioannis Melakopoulos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Zoledronic Acid ◽  
Median Number ◽  
Osteonecrosis Of The Jaw ◽  
Bisphosphonate Treatment ◽  
Cumulative Hazard ◽  
Dental Procedures ◽  
History Of ◽  
Number Of Treatment ◽  
Other Neoplasms

Purpose Osteonecrosis of the jaw (ONJ) has been associated recently with the use of pamidronate and zoledronic acid. We studied the incidence, characteristics, and risk factors for the development of ONJ among patients treated with bisphosphonates for bone metastases. Patients and Methods ONJ was assessed prospectively since July 2003. The first bisphosphonate treatment among patients with ONJ was administered in 1997. Two hundred fifty-two patients who received bisphosphonates since January 1997 were included in this analysis. Results Seventeen patients (6.7%) developed ONJ: 11 of 111 (9.9%) with multiple myeloma, two of 70 (2.9%) with breast cancer, three of 46 (6.5%) with prostate cancer, and one of 25 (4%) with other neoplasms (P = .289). The median number of treatment cycles and time of exposure to bisphosphonates were 35 infusions and 39.3 months for patients with ONJ compared with 15 infusions (P < .001) and 19 months (P = .001), respectively, for patients with no ONJ. The incidence of ONJ increased with time to exposure from 1.5% among patients treated for 4 to 12 months to 7.7% for treatment of 37 to 48 months. The cumulative hazard was significantly higher with zoledronic acid compared with pamidronate alone or pamidronate and zoledronic acid sequentially (P < .001). All but two patients with ONJ had a history of dental procedures within the last year or use of dentures. Conclusion The use of bisphosphonates seems to be associated with the development of ONJ. Length of exposure seems to be the most important risk factor for this complication. The type of bisphosphonate may play a role and previous dental procedures may be a precipitating factor.

scholarly journals Prevalence of Obesity in Ambulatory Patients with Cerebral Palsy in the Korean Population: A Single Institution's Experience

2011 ◽  
Vol 3 (3) ◽  
pp. 211 ◽  
Author(s):  
Dae Gyu Kwon ◽  
Seung Chul Kang ◽  
Chin Youb Chung ◽  
Sang Hyeong Lee ◽  
Kyoung Min Lee ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Korean Population ◽  
Ambulatory Patients ◽  
Prevalence Of Obesity

scholarly journals BMP-2 Promotes Bone Formation in Bone Defects in Which Bone Remodeling Is Suppressed by Long-Term and High-Dose Zoledronic Acid

2021 ◽  
Author(s):  
Young Jae Moon ◽  
Seongyup Jeong ◽  
Kwang-Bok Lee
Keyword(s):  
Zoledronic Acid ◽  
Collagen Sponge ◽  
High Dose ◽  
Bisphosphonate Treatment ◽  
Union Rate ◽  
Defect Model ◽  
Absorbable Collagen Sponge ◽  
Freeze Dried ◽  
Radiographic Union

Abstract Background: The use of long-term and high-dose bisphosphate is associated with severely suppressed bone turnover and the delayed union of fractures. However, therapeutic methods to overcome the negative effects of bisphosphonate use are lacking. Bone morphogenetic proteins (BMPs) are powerful osteoinductive proteins. We hypothesized that BMPs had similar effects as autografts in patients with decreased bone healing potential due to long-term bisphosphonate treatment. The purpose of this study was to compare BMPs with demineralized freeze-dried bone grafts and autografts in a rat femoral bone defect model with long-term and high-dose bisphosphonate treatment. Methods: Forty rats were divided into the following four groups depending upon the materials implanted into the femoral defect after ten weeks of bisphosphonate (zoledronic acid) injections: Group I: absorbable collagen sponge (control); group II: demineralized freeze-dried bone graft; group III: autogenous bone graft; and group IV: rhBMP-2 with an absorbable collagen sponge. Radiographic union, micro computed tomography (CT) analysis, manual palpation, and histologic analysis were evaluated. Results: The radiographic union rate, manual union rate, and micro-CT bone volume in groups III and IV were significantly higher than those in groups I and II. Groups III and IV showed similar results to each other. Although the amount of immature bone in the BMP-treated group was large, the effect was similar to that of autografts in the bone defect model in which bone turnover was severely reduced by bisphosphonate treatment. Conclusion: BMP might be a good substitute for autografts in patients with decreased bone healing potential due to long-term bisphosphonate treatment.

Psoas Release at the Pelvic Brim in Ambulatory Patients with Cerebral Palsy: Operative Technique and Functional Outcome

1997 ◽  
Vol 17 (5) ◽  
pp. 563-570 ◽  
Author(s):  
D. H. Sutherland ◽  
J. L. Zilberfarb ◽  
K. R. Kaufman ◽  
M. P. Wyatt ◽  
H. G. Chambers
Keyword(s):  
Cerebral Palsy ◽  
Functional Outcome ◽  
Operative Technique ◽  
Pelvic Brim ◽  
Ambulatory Patients
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