Vascularisation and progenitor cells of primary and secondary ossification centres in the human growth plate

2013 ◽  
Author(s):  
Sonja M Walzer ◽  
Erdal Cetin ◽  
Ruth Grubl-Barabas ◽  
Irene Sulzbacher ◽  
Beate Ruger ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Growth Plate ◽  
Human Growth ◽  
Secondary Ossification Centres

scholarly journals Vascularization of primary and secondary ossification centres in the human growth plate

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Sonja M Walzer ◽  
Erdal Cetin ◽  
Ruth Grübl-Barabas ◽  
Irene Sulzbacher ◽  
Beate Rueger ◽  
...  
Keyword(s):  
Growth Plate ◽  
Human Growth ◽  
Secondary Ossification Centres

Investigation of RARg Signaling in Human Growth-Plate Chondrocytes

2021 ◽  
Author(s):  
Joshua M. Abzug ◽  
Hongying Tian ◽  
Masatake Matsuoka ◽  
Danielle A. Hogarth ◽  
Casey M. Codd ◽  
...  
Keyword(s):  
Growth Plate ◽  
Human Growth ◽  
Growth Plate Chondrocytes

scholarly journals Cellular reactions to biodegradable magnesium alloys on human growth plate chondrocytes and osteoblasts

2013 ◽  
Vol 38 (4) ◽  
pp. 881-889 ◽  
Author(s):  
Karin Pichler ◽  
Tanja Kraus ◽  
Elisabeth Martinelli ◽  
Patrick Sadoghi ◽  
Giuseppe Musumeci ◽  
...  
Keyword(s):  
Growth Plate ◽  
Magnesium Alloys ◽  
Human Growth ◽  
Growth Plate Chondrocytes ◽  
Biodegradable Magnesium

scholarly journals RECENT RESEARCH ON THE GROWTH PLATE: Recent insights into the regulation of the growth plate

2014 ◽  
Vol 53 (1) ◽  
pp. T1-T9 ◽  
Author(s):  
Julian C Lui ◽  
Ola Nilsson ◽  
Jeffrey Baron
Keyword(s):  
Growth Plate ◽  
Bone Morphogenetic Proteins ◽  
Bone Growth ◽  
Association Studies ◽  
Expression Patterns ◽  
Human Growth ◽  
Cytokine Signaling ◽  
Genome Wide Association Studies ◽  
Paracrine Factors ◽  
Large Numbers

For most bones, elongation is driven primarily by chondrogenesis at the growth plates. This process results from chondrocyte proliferation, hypertrophy, and extracellular matrix secretion, and it is carefully orchestrated by complex networks of local paracrine factors and modulated by endocrine factors. We review here recent advances in the understanding of growth plate physiology. These advances include new approaches to study expression patterns of large numbers of genes in the growth plate, using microdissection followed by microarray. This approach has been combined with genome-wide association studies to provide insights into the regulation of the human growth plate. We also review recent studies elucidating the roles of bone morphogenetic proteins, fibroblast growth factors, C-type natriuretic peptide, and suppressor of cytokine signaling in the local regulation of growth plate chondrogenesis and longitudinal bone growth.

The synthesis of type X collagen by bovine and human growth-plate chondrocytes

1991 ◽  
Vol 99 (3) ◽  
pp. 641-649 ◽  
Author(s):  
A. Marriott ◽  
S. Ayad ◽  
M.E. Grant
Keyword(s):  
Growth Plate ◽  
Type I Collagen ◽  
Polyacrylamide Gel Electrophoresis ◽  
Human Growth ◽  
Type I ◽  
Collagen Gels ◽  
Type X Collagen ◽  
Growth Plate Chondrocytes ◽  
Growth Plate Cartilage ◽  
Disulphide Bonds

Chondrocytes were isolated from bovine growth-plate cartilage and cultured within type I collagen gels. A major collagen with chains of Mr 59,000, decreasing to 47,000 on pepsinization, was synthesized and identified as type X collagen. This collagen was cleaved at two sites by mammalian collagenase, resulting in a major triple-helical fragment with chains of Mr 32,000. The species of Mr 59,000, 47,000 and 32,000 were not detected by SDS-polyacrylamide gel electrophoresis before reduction, indicating the presence of disulphide bonds within the triple helix. In contrast, similar biosynthetic studies with human growth-plate cartilage in organ culture, indicated that human type X collagen does not contain disulphide bonds. A polyclonal antiserum was raised to bovine type X collagen and used in immunolocalization studies to provide direct evidence for the association of type X collagen with the hypertrophic chondrocytes in both bovine and human growth plates during development.

Human growth plate contains aggrecan fragments that can be generated by m-calpain

2010 ◽  
Vol 52 (3) ◽  
pp. 235-241 ◽  
Author(s):  
Toshiyuki Inoue ◽  
Kiichi Suzuki ◽  
Hideaki Maehara ◽  
Katsuji Shimizu
Keyword(s):  
Growth Plate ◽  
Human Growth

scholarly journals Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height

2012 ◽  
Vol 21 (23) ◽  
pp. 5193-5201 ◽  
Author(s):  
Julian C. Lui ◽  
Ola Nilsson ◽  
Yingleong Chan ◽  
Cameron D. Palmer ◽  
Anenisia C. Andrade ◽  
...  
Keyword(s):  
Growth Plate ◽  
Association Studies ◽  
Human Growth ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Expression Microarray ◽  
Novel Genes ◽  
Genome Wide

Distinct Expression of APO-1/Fas and Caspase-8 in the Human Growth Plate

2004 ◽  
Vol 74 (2) ◽  
pp. 181-186 ◽  
Author(s):  
E. Cetin ◽  
W. Girsch ◽  
G. Brand ◽  
D. Thurnher ◽  
E. M. Cetin ◽  
...  
Keyword(s):  
Growth Plate ◽  
Human Growth ◽  
Caspase 8
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