scholarly journals Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height

2012 ◽  
Vol 21 (23) ◽  
pp. 5193-5201 ◽  
Author(s):  
Julian C. Lui ◽  
Ola Nilsson ◽  
Yingleong Chan ◽  
Cameron D. Palmer ◽  
Anenisia C. Andrade ◽  
...  
Keyword(s):  
Growth Plate ◽  
Association Studies ◽  
Human Growth ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Expression Microarray ◽  
Novel Genes ◽  
Genome Wide

scholarly journals Post Genome-Wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-Gene Interaction and High Predictive Value

PLoS ONE ◽  
2008 ◽  
Vol 3 (5) ◽  
pp. e2031 ◽  
Author(s):  
Stéphane Cauchi ◽  
David Meyre ◽  
Emmanuelle Durand ◽  
Christine Proença ◽  
Michel Marre ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Predictive Value ◽  
Association Studies ◽  
Gene Interaction ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Novel Genes ◽  
Genome Wide

scholarly journals Insights and Implications of Genome-Wide Association Studies of Height

2018 ◽  
Vol 103 (9) ◽  
pp. 3155-3168 ◽  
Author(s):  
Michael H Guo ◽  
Joel N Hirschhorn ◽  
Andrew Dauber
Keyword(s):  
Adult Height ◽  
Association Studies ◽  
Evidence Synthesis ◽  
Human Growth ◽  
Biological Pathways ◽  
Genome Wide Association ◽  
Growth Disorders ◽  
Genome Wide Association Studies ◽  
Growth Factor Signaling ◽  
Genome Wide

Abstract Context In the last decade, genome-wide association studies (GWASs) have catalyzed our understanding of the genetics of height and have identified hundreds of regions of the genome associated with adult height and other height-related body measurements. Evidence Acquisition GWASs related to height were identified via PubMed search and a review of the GWAS catalog. Evidence Synthesis The GWAS results demonstrate that height is highly polygenic: that is, many thousands of genetic variants distributed across the genome each contribute to an individual’s height. These height-associated regions of the genome are enriched for genes in known biological pathways involved in growth, such as fibroblast growth factor signaling, as well as for genes expressed in relevant tissues, such as the growth plate. GWASs can also uncover previously unappreciated biological pathways, such as theSTC2/PAPPA/IGFBP4 pathway. The genes implicated by GWASs are often the same genes that are the genetic causes of Mendelian growth disorders or skeletal dysplasias, and GWAS results can provide complementary information about these disorders. Conclusions Here, we review the rationale behind GWASs and what we have learned from GWASs for height, including how it has enhanced our understanding of the underlying biology of human growth. We also highlight the implications of GWASs in terms of prediction of adult height and our understanding of Mendelian growth disorders.

scholarly journals Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

2012 ◽  
Vol 21 (24) ◽  
pp. 5329-5343 ◽  
Author(s):  
Daniel I. Chasman ◽  
Christian Fuchsberger ◽  
Cristian Pattaro ◽  
Alexander Teumer ◽  
Carsten A. Böger ◽  
...  
Keyword(s):  
Kidney Function ◽  
Association Studies ◽  
Genome Wide Association ◽  
Biological Knowledge ◽  
Genome Wide Association Studies ◽  
Novel Genes ◽  
Genome Wide
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