Altered bone material properties in HLA-B27 rats, an animal model for arthritis, ankylosing spondylitis, and gastrointestinal inflammation

2013 ◽  
Author(s):  
Sonja Gamsjaeger ◽  
Eleftherios P. Paschalis ◽  
Ruth Zoehrer ◽  
Klaus Klaushofer ◽  
Dimitris N. Tatakis
Keyword(s):  
Animal Model ◽  
Ankylosing Spondylitis ◽  
Material Properties ◽  
Hla B27 ◽  
Bone Material ◽  
Bone Material Properties ◽  
Gastrointestinal Inflammation

scholarly journals Altered Bone Material Properties in HLA-B27 Rats Include Reduced Mineral to Matrix Ratio and Altered Collagen Cross-Links

2014 ◽  
Vol 29 (11) ◽  
pp. 2382-2391 ◽  
Author(s):  
Sonja Gamsjaeger ◽  
Apurva K Srivastava ◽  
Jon E Wergedal ◽  
Jochen Zwerina ◽  
Klaus Klaushofer ◽  
...  
Keyword(s):  
Material Properties ◽  
Hla B27 ◽  
Bone Material ◽  
Bone Material Properties ◽  
Cross Links

Outcomes of Vascularized Bone Allotransplantation with Surgically Induced Autogenous Angiogenesis in a Large Animal Model: Bone Healing, Remodeling, and Material Properties

2019 ◽  
Vol 36 (02) ◽  
pp. 082-092 ◽  
Author(s):  
Rudolph H. Houben ◽  
Dimitra Kotsougiani ◽  
Patricia F. Friedrich ◽  
Alexander Y. Shin ◽  
Allen T. Bishop
Keyword(s):  
Animal Model ◽  
Bone Formation ◽  
Bone Healing ◽  
Material Properties ◽  
Large Animal Model ◽  
Large Animal ◽  
Bone Material ◽  
Bone Material Properties ◽  
Normal Bone ◽  
Av Bundle

Background Bone vascularized composite allotransplantation (VCA) is a possible alternative for the treatment of large bone defects. Clinical application of VCAs is limited by the need for life-long immunosuppression (IS). We report an alternative method to maintain bone allotransplant viability in a large animal model without the need for life-long IS by using autogenous vessel implantation. Methods Fourteen bone only VCAs were transplanted in a porcine tibia defect model with short-term IS. Two groups were used to evaluate the effect of the implantation of an autogenous arteriovenous (AV)-bundle, therefore the only difference between the groups was the patency of the AV-bundle. We radiographically evaluated bone healing and allogenic pedicle patency. AV-bundle patency and union were evaluated with micro-CT. Bone remodeling was assessed with histomorphometry and material properties were evaluated with axial compression testing and cyclic reference point indentation. Results Two subjects did not reach the final time point. Twelve tibiae healed proximally, and nine at the distal transplant–bone interface. Bone allotransplants showed their viability in the first 4 to 6 weeks by significant periosteal bridging arising from the transplant and maintained pedicle patency. Bone material properties were not affected by the implantation of an AV-bundle when compared with ligated AV-bundle controls, but diminished compared with normal bone. Significantly higher bone formation rates resulted from the implantation of a patent AV-bundle. Conclusion New periosteal bone formation and subsequent bone healing result from blood flow through the microsurgically repaired nutrient blood supply, demonstrated by maintained allogenic pedicle patency. The implantation of a patent autogenous AV-bundle has no adverse effect on material properties, but a positive effect on bone remodeling of endosteal surfaces despite thrombosis of the allogenic pedicle. Bone material properties change after transplantation compared with normal bone, although 20-weeks survival time is relatively short for the final evaluation of bone material properties.

Bone material properties as measured by Reference Point Indentation are low in subjects with acromegaly

2016 ◽  
Author(s):  
Frank Malgo ◽  
Neveen A T Hamdy ◽  
Alberto M Pereira ◽  
Nienke R Biermasz ◽  
Natasha M Appelman-Dijkstra
Keyword(s):  
Material Properties ◽  
Reference Point ◽  
Bone Material ◽  
Bone Material Properties ◽  
Reference Point Indentation

scholarly journals Developments in Modelling Bone Screwing

2020 ◽  
Vol 6 (3) ◽  
pp. 111-114
Author(s):  
Jack Wilkie ◽  
Paul D. Docherty ◽  
Knut Möller
Keyword(s):  
Material Properties ◽  
Frictional Coefficient ◽  
Viscous Friction ◽  
Model Parameters ◽  
General Shape ◽  
Bone Material ◽  
Bone Material Properties ◽  
Modelling Methodology ◽  
Recorded Data ◽  
Friction Models

AbstractINTRODUCTION: A torque-rotation model of the bone-screwing process has been proposed. Identification of model parameters using recorded data could potentially be used to determine the material properties of bone. These properties can then be used to recommend tightening torques to avoid over or under-tightening of bone screws. This paper improves an existing model to formulate it in terms of material properties and remove some assumptions. METHOD: The modelling methodology considers a critical torque, which is required to overcome friction and advance the screw into the bone. Below this torque the screw may rotate with elastic deformation of the bone tissue, and above this the screw moves relative to the bone, and the speed is governed by a speed-torque model of the operator’s hand. The model is formulated in terms of elastic modulus, ultimite tensile strength, and frictional coefficient of the bone and the geometry of the screw and hole. RESULTS: The model output shows the speed decreasing and torque increasing as the screw advances into the bone, due to increasing resistance. The general shape of the torque and speed follow the input effort. Compared with the existing model, this model removes the assumption of viscous friction, models the increase in friction as the screw advances into the bone, and is directly in terms of the bone material properties. CONCLUSION: The model presented makes significant improvements on the existing model. However it is intended for use in parameter identification, which was not evaluated here. Further simulation and experimental validation is required to establish the accuracy and fitness of this model for identifying bone material properties.

scholarly journals Impact microindentation assesses cortical bone material properties in humans

Bone Reports ◽  
2020 ◽  
Vol 13 ◽  
pp. 100395
Author(s):  
Stamatia Rokidi ◽  
Natalie Bravenboer ◽  
Sonja Gamsjaeger ◽  
Pascale Chavassieux ◽  
Jochen Zwerina ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Material Properties ◽  
Bone Material ◽  
Bone Material Properties ◽  
Impact Microindentation

scholarly journals Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties

Bone ◽  
2014 ◽  
Vol 61 ◽  
pp. 191-200 ◽  
Author(s):  
Maxime A. Gallant ◽  
Drew M. Brown ◽  
Max Hammond ◽  
Joseph M. Wallace ◽  
Jiang Du ◽  
...  
Keyword(s):  
Material Properties ◽  
Bone Cell ◽  
Bone Material ◽  
Bone Material Properties

scholarly journals Effects of alendronate and risedronate on bone material properties in actively forming trabecular bone surfaces

2012 ◽  
Vol 27 (5) ◽  
pp. 995-1003 ◽  
Author(s):  
Birgit Hofstetter ◽  
Sonja Gamsjaeger ◽  
Roger J Phipps ◽  
Robert R Recker ◽  
Frank H Ebetino ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Material Properties ◽  
Bone Material ◽  
Bone Material Properties
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