Serum levels of estrogens and of five 'steroid sensitive' proteins in early normal pregnancy

1988 ◽  
Vol 118 (2) ◽  
pp. 239-244 ◽  
Author(s):  
Lottie Skjöldebrand Sparre ◽  
Jan Brundin ◽  
Anders Carlström ◽  
Bo von Schoultz ◽  
Kjell Carlström
Keyword(s):  
Serum Levels ◽  
Normal Pregnancy ◽  
The Other ◽  
Sex Hormone Binding Globulin ◽  
Serum Concentrations ◽  
Hormone Binding ◽  
Protein Levels ◽  
Physiological Regulator ◽  
Steroid Sensitive ◽  
Estradiol 17Β

Abstract. Serum concentrations of sex hormone binding globulin (SHBG), pregnancy associated α2-glycoprotein (α2-PAG), caeruloplasmin (Cp), α1-antitrypsin (α1-At) and transferrin (Tf), unconjugated and total estrone, and unconjugated estradiol-17β were measured twice at a 4–5 week interval in 43 cases of early normal pregnancy (gestational weeks 6–19). Significant correlations between estrogen and protein levels in the total material were observed for all proteins except for Tf. However, within 2-week intervals of pregnancy, significant correlations were obtained only in certain intervals between estrogens on one hand and SHBG, Cp and α1-At on the other. Significant correlations between rates of increase of estrogens and of proteins were obtained only at certain occasions for SHBG, Cp, Tf and α1-At. The results indicate that, although estrogens may have a modulatory function in 'steroidsensitive' protein synthesis, they are probably not the main physiological regulator.

scholarly journals Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Hiroki Yamazaki ◽  
Akifumi Kushiyama ◽  
Hideyuki Sakoda ◽  
Midori Fujishiro ◽  
Takeshi Yamamotoya ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Protective Effect ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Lipid Degradation ◽  
Protein Levels ◽  
Anti Inflammatory ◽  
20 Nm

Sex hormone-binding globulin (SHBG) is a serum protein released mainly by the liver, and a low serum level correlates with a risk for metabolic syndrome including diabetes, obesity, and cardiovascular events. However, the underlying molecular mechanism(s) linking SHBG and metabolic syndrome remains unknown. In this study, using adipocytes and macrophages, we focused on the in vitro effects of SHBG on inflammation as well as lipid metabolism. Incubation with 20 nM SHBG markedly suppressed lipopolysaccharide- (LPS-) induced inflammatory cytokines, such as MCP-1, TNFα, and IL-6 in adipocytes and macrophages, along with phosphorylations of JNK and ERK. Anti-inflammatory effects were also observed in 3T3-L1 adipocytes cocultured with LPS-stimulated macrophages. In addition, SHBG treatment for 18 hrs or longer significantly induced the lipid degradation of differentiated 3T3-L1 cells, with alterations in its corresponding gene and protein levels. Notably, these effects of SHBG were not altered by coaddition of large amounts of testosterone or estradiol. In conclusion, SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome.

Effect of anordrin on serum levels of sex hormone binding globulin, caeruloplasmin and ovarian function

Contraception ◽  
1987 ◽  
Vol 36 (5) ◽  
pp. 541-548 ◽  
Author(s):  
Si Song ◽  
J.K. Chen ◽  
M.L. He ◽  
S.H. Zao ◽  
K. Fothcrby
Keyword(s):  
Ovarian Function ◽  
Serum Levels ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Androgen and oestrogen dynamics in hyperthyroidism

1982 ◽  
Vol 95 (1) ◽  
pp. 105-115 ◽  
Author(s):  
E. C. Ridgway ◽  
Farahe Maloof ◽  
Christopher Longcope
Keyword(s):  
Serum Levels ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Metabolic Clearance ◽  
Hormone Binding ◽  
Clearance Rates ◽  
Production Rates ◽  
Normal Range

Using constant infusions of [3H]testosterone and [14C]oestradiol or [3H]androstenedione and [14C]oestrone the dynamics of androgen and oestrogen metabolism and production in patients with hyperthyroidism were measured. The metabolic clearance rates of testosterone and oestradiol were decreased but those of androstenedione and oestrone were within the normal range. The conversion ratios of testosterone to androstenedione and of testosterone to dihydrotestosterone (DHT) were decreased whereas those of androstenedione to testosterone and androstenedione to DHT were increased. These changes could be explained by increased serum levels of sex hormone binding globulin which binds testosterone and DHT but not androstenedione. The fraction of androstenedione infused into and measured as oestrone in the blood was normal in seven out of nine subjects and the fraction of testosterone infused and measured as oestradiol was normal in all nine subjects. The production rates of testosterone and oestradiol were in the normal range but the production rates of androstenedione and oestrone were raised in half the subjects.

Sign in / Sign up

Export Citation Format

Share Document