Androgen and oestrogen dynamics in hyperthyroidism

1982 ◽  
Vol 95 (1) ◽  
pp. 105-115 ◽  
Author(s):  
E. C. Ridgway ◽  
Farahe Maloof ◽  
Christopher Longcope
Keyword(s):  
Serum Levels ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Metabolic Clearance ◽  
Hormone Binding ◽  
Clearance Rates ◽  
Production Rates ◽  
Normal Range

Using constant infusions of [3H]testosterone and [14C]oestradiol or [3H]androstenedione and [14C]oestrone the dynamics of androgen and oestrogen metabolism and production in patients with hyperthyroidism were measured. The metabolic clearance rates of testosterone and oestradiol were decreased but those of androstenedione and oestrone were within the normal range. The conversion ratios of testosterone to androstenedione and of testosterone to dihydrotestosterone (DHT) were decreased whereas those of androstenedione to testosterone and androstenedione to DHT were increased. These changes could be explained by increased serum levels of sex hormone binding globulin which binds testosterone and DHT but not androstenedione. The fraction of androstenedione infused into and measured as oestrone in the blood was normal in seven out of nine subjects and the fraction of testosterone infused and measured as oestradiol was normal in all nine subjects. The production rates of testosterone and oestradiol were in the normal range but the production rates of androstenedione and oestrone were raised in half the subjects.

Effect of anordrin on serum levels of sex hormone binding globulin, caeruloplasmin and ovarian function

Contraception ◽  
1987 ◽  
Vol 36 (5) ◽  
pp. 541-548 ◽  
Author(s):  
Si Song ◽  
J.K. Chen ◽  
M.L. He ◽  
S.H. Zao ◽  
K. Fothcrby
Keyword(s):  
Ovarian Function ◽  
Serum Levels ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Peripheral hormone levels in healthy subjects during controlled fasting

1986 ◽  
Vol 113 (3) ◽  
pp. 457-462 ◽  
Author(s):  
Ragnar Tegelman ◽  
Pia Lindeskog ◽  
Kjell Carlström ◽  
Åke Pousette ◽  
Rolf Blomstrand
Keyword(s):  
Protein Binding ◽  
Testosterone Level ◽  
Healthy Subjects ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Metabolic Clearance ◽  
Dehydroepiandrosterone Sulphate ◽  
Hormone Binding

Abstract. The effect of one week of controlled fasting (3 1 of fluid containing 50 g of carbohydrate/day) upon the serum levels of hormones, sex hormone binding globulin, and albumin was studied in healthy subjects. Fasting caused decreased levels of prolactin and T3, no changes in the levels of TSH, FSH, LH, dehydroepiandrosterone, 4-androstene-3,17-dione, total oestrone, and total testosterone, and increased levels of cortisol, dehydroepiandrosterone sulphate and albumin. A significant positive correlation was found between albumin and dehydroepiandrosterone sulphate. Fasting rapidly increased the levels of sex hormone binding globulin and decreased the percentage of free testosterone and the calculated free testosterone level in both sexes. A decreased metabolic clearance of certain steroids (cortisol, dehydroepiandrosterone sulphate) owing to an increased protein binding may be one of the endocrine consequences of fasting. An increased protein binding of testosterone may be outweighed by a decreased gonadal production, thus resulting in an unchanged total testosterone level. The increased sex hormone binding globulin level could not be explained by changes in gonadal and thyroid hormones.

scholarly journals TESTOSTERONE CHANGES IN PATIENTS WITH LIVER CIRRHOSIS BEFORE AND AFTER ORTHOTOPIC LIVER TRANSPLANTATION AND ITS CORRELATION WITH MELD

2014 ◽  
Vol 51 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Rodrigo NITSCHE ◽  
Júlio Cezar Uili COELHO ◽  
Alexandre Coutinho Teixeira de FREITAS ◽  
Clementino ZENI NETO ◽  
Eduardo MARTINS
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Orthotopic Liver Transplantation ◽  
Free Testosterone ◽  
Serum Levels ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
End Stage Liver Disease ◽  
End Stage

Context Hypogonadism is a common clinical situation in male patients with liver cirrhosis. Objectives The aim of the present study was to evaluate the effects of orthotopic liver transplantation on testosterone, free testosterone and sex hormone-binding globulin in male with advanced liver disease and also to determine the relationship of these changes with Model for End-stage Liver Disease (MELD) score. Methods In a prospective study, serum levels of testosterone, free testosterone and sex hormone-binding globulin of 30 male adult patients with end-stage liver disease were measured 2 to 4 hours before and 6 months after orthotopic liver transplantation. Results Total testosterone levels increased after orthotopic liver transplantation and the number of patients with normal testosterone levels increased from 18 to 24. Free testosterone mean level in the pre-transplant group was 7.8 pg/mL and increased to 11.5 pg/mL (P = 0.10) and sex hormone-binding globulin level decreased after orthotopic liver transplantation returning to normal levels in MELD ≤18 - group (A) (P<0.05). Conclusions Serum level changes of testosterone, free testosterone and sex hormone-binding globulin are more pronounced in cirrhotic males with MELD ≤18. Serum levels of testosterone and free testosterone increase and serum levels of sex hormone-binding globulin decrease after orthotopic liver transplantation.

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