Effects of oestrogen and human growth hormone on pregnancy-associated plasma proteins in the rat

1987 ◽  
Vol 116 (2) ◽  
pp. 299-304 ◽  
Author(s):  
L. Carlsson-Bostedt ◽  
N. Frölander ◽  
S. Edén ◽  
T. Stigbrand ◽  
B. von Schoultz
Keyword(s):  
Growth Hormone ◽  
Acute Phase ◽  
Human Growth Hormone ◽  
Plasma Proteins ◽  
Human Growth ◽  
Male Rats ◽  
Complement Factor ◽  
Pronounced Increase ◽  
Additive Influence ◽  
Protein Response

Abstract. The serum concentrations of pregnancy-associated murine protein-1 (PAMP-1), acute phase α2macroglobulin, albumin, transferrin, and complement factor 3(C3) were followed in male rats during continuous infusions of oestradiol-17β and human growth hormone. Three different patterns of protein response could be distinguished. A distinct acute phase response without any additive influence of the given hormones was recorded for α2-macroglobulin, whereas the levels of albumin, transferrin and C3 were virtually unaffected throughout the experiment. Growth hormone gave a rapid and pronounced increase of PAMP-1 levels, whereas the response to oestradiol of this 'steroid-sensitive' protein was significantly weaker and delayed. It is suggested that the apparent oestrogenic influence on certain pregnancy-associated plasma proteins is mediated via growth hormone.

RADIOAUTOGRAPHIC STUDIES ON THE LOCALIZATION OF 125I-LABELLED HUMAN LUTEINIZING AND GROWTH HORMONE IN IMMATURE MALE RATS

1969 ◽  
Vol 43 (1) ◽  
pp. 105-111 ◽  
Author(s):  
D. M. DE KRETSER ◽  
K. J. CATT ◽  
H. G. BURGER ◽  
G. C. SMITH
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Luteinizing Hormone ◽  
Human Growth Hormone ◽  
Light Microscope ◽  
Human Growth ◽  
Proximal Convoluted Tubule ◽  
Male Rats ◽  
Immature Male ◽  
Parenchymal Cells

SUMMARY Twenty-day-old male rats were injected intraperitoneally with either human luteinizing hormone (HLH) or human growth hormone (HGH) labelled with 125I. The localization of these hormones 1–2 hr. after injection was examined under the light microscope after radioautography. Major sites of localization of labelled LH were the interstitial cells of the testis and the proximal convoluted tubule of the kidney. Some hormone was also present in adipose tissue, hepatic parenchymal cells, the mesothelial lining of the peritoneum and underlying macrophages. HGH was localized principally in the proximal convoluted tubule of the kidney with some hormone present in liver, adipose tissue, and the suprarenal cortex.

EFFECTS OF HUMAN GROWTH HORMONE ON THE SECRETION OF RAT GROWTH HORMONE

1980 ◽  
Vol 86 (1) ◽  
pp. 165-169 ◽  
Author(s):  
J. O. WILLOUGHBY ◽  
MARGARET MENADUE ◽  
P. ZEEGERS ◽  
P. H. WISE ◽  
J. R. OLIVER
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Male Rats ◽  
Mean Frequency ◽  
Rat Growth ◽  
The Mean

Human growth hormone (hGH) was administered to chronically cannulated male rats and its effect upon the physiological secretory patterns of rat growth hormone (rGH) and prolactin were observed. In comparison with injected control animals, a reduction in the size of spontaneous secretory bursts of rGH was apparent when hormone concentrations were compared 3–6 h after administration of hGH (136·27 ± 27·31 (s.e.m.) v. 76·22 ± 20·98 ng/ml respectively). However, the mean frequency of secretory episodes of rGH was unaltered. It is therefore postulated that endogenous rGH may modulate the amplitude but not the rhythmicity of secretory episodes of rGH.

THE EARLY ANTIBODY RESPONSE TO HUMAN GROWTH HORMONE

1971 ◽  
Vol 67 (3) ◽  
pp. 457-462
Author(s):  
Stanley M. Warner ◽  
S. Douglas Frasier
Keyword(s):  
Growth Hormone ◽  
Antibody Response ◽  
Human Growth Hormone ◽  
Specific Antibody ◽  
Plasma Proteins ◽  
Human Growth ◽  
Sequential Development ◽  
Hormone Administration ◽  
Specific Antisera ◽  
Ig G

ABSTRACT The development of antibodies to human growth hormone (HGH) was studied in three growth hormone deficient patients utilizing specific antisera to Ig G and Ig M immunoglobulins. At 2½ weeks after beginning growth hormone administration binding of HGH131I to Ig M (12.1–16.3 %) and Ig G (8.8–11.2 %) immunoglobulins was demonstrated. At 13 weeks after the onset of therapy binding to Ig M had decreased (7.2-9.4 %) and the binding to Ig G had increased (11.2–15.7 %). The binding of HGH131I to immunoglobulins was inhibited by unlabelled HGH. These findings, which are typical of the sequential development of antibodies of different immunoglobulin classes seen in the early antibody response, strengthen the concept that the binding of HGH131I to plasma proteins observed in response to HGH therapy represents the development of specific antibody.

Recombinant human growth hormone modulates the hepatic acute-phase response and P-selectin in burned rats

Burns ◽  
2002 ◽  
Vol 28 (8) ◽  
pp. 760-764 ◽  
Author(s):  
Mahmut Basoglu ◽  
Ahmet Kiziltunc ◽  
M.Ilhan Yildirgan ◽  
Kenan Gumustekin ◽  
Metehan Gumus ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Acute Phase ◽  
Human Growth Hormone ◽  
Acute Phase Response ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Phase Response

Comparison of methionyl human growth hormone and pituitary growth hormone on somatic growth of hypophysectomized rats

1984 ◽  
Vol 107 (2) ◽  
pp. 192-198 ◽  
Author(s):  
A. Skottner ◽  
A. Forsman ◽  
E. Löfberg ◽  
K.-G. Thorngren
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Bone Growth ◽  
Biological Effects ◽  
Human Growth ◽  
Male Rats ◽  
Cartilage Growth ◽  
Human Pituitary ◽  
Longitudinal Bone Growth ◽  
Pituitary Growth Hormone

Abstract. In hypophysectomized male rats the biological effects of two batches of methionyl human growth hormone, Somatonorm®, (met-hGH), have been compared to those of human pituitary growth hormone, Crescormon® (hGH). The rats were treated with doses ranging from 10 mIU per day to 145 mIU per day for 10 days. The parameters studied were total weight gain, longitudinal bone growth, measured by the tetracycline method and indirect cartilage growth, measured by uptake of radioactive sulphate. The results obtained demonstrated that Somatonorm® stimulated weight increase in a linear and dose-dependent way, similar to that seen with the native hormone. Longitudinal bone growth, measured by the tetracycline method and the growth of different cartilages, measured as uptake of radioactive sulphate, were also similar between the two hormones.

Sign in / Sign up

Export Citation Format

Share Document